Results 31 to 40 of about 11,945,723 (183)

Pyrazole‐Derived Antibacterial Compounds Effectively Treat Methicillin‐Resistant Staphylococcus Aureus Infections by Inhibiting Aspartate Transcarbamoylase

Advanced Science, EarlyView.
This study unveils a novel antibacterial mechanism against MRSA, in which the compound Py‐27 selectively targets and inhibits aspartate transcarbamoylase (ATCase), a key enzyme in pyrimidine synthesis. This inhibition disrupts DNA replication, induces oxidative damage, leading to potent bactericidal activity.
Xiaorong Yang, Xinyuan Cao, Lixia Dai, Feng Yang, Jing Wang, Yudong Ma, Tong Bu, Zile Gong, Xueyan Liu, Changcai Bai, Xiaolou Miao, Xiaofei Shang   +11 more
wiley   +1 more source

Bayesian polarization calibration and imaging in very long baseline interferometry

Astronomy & Astrophysics
Context. Extracting polarimetric information from very long baseline interferometry (VLBI) data is demanding but vital to understanding the synchrotron radiation process and the magnetic fields of celestial objects, such as active galactic nuclei (AGNs).
Kim Jong-Seo, Roth Jakob, Park Jongho, Livingston Jack D., Arras Philipp, Enßlin Torsten A., Janssen Michael, Zensus Johann Anton, Lobanov Andrei P.   +8 more
doaj   +1 more source

Super-Resolved Image of M87 Observed with East Asian VLBI Network

Galaxies, 2023
Obtaining high-resolution images at centimeter-or-longer wavelengths is vital for understanding the physics of jets. We reconstructed images from the M87 22 GHz data observed with the East Asian VLBI Network (EAVN) by using the regularized maximum ...
Fumie Tazaki, Yuzhu Cui, Kazuhiro Hada, Motoki Kino, Ilje Cho, Guang-Yao Zhao, Kazunori Akiyama, Yosuke Mizuno, Hyunwook Ro, Mareki Honma, Ru-Sen Lu, Zhi-Qiang Shen, Lang Cui, Yoshinori Yonekura   +13 more
doaj   +1 more source

Toward Personalized Theranostics: A Modular PET Platform for Antibody‐Based Imaging and Therapy

Advanced Science, EarlyView.
This modular, site‐specific antibody platform enables customizable conjugates for PET imaging and therapy. Interchangeable payloads – including radiometals, cytotoxics, and fluorophores – support adaptable, multimodal applications with limited off‐target effects. In vivo, the DFO/DOTAGA bischelate immunoconjugate provided clear tumor delineation in PET/
Delphine Vivier, Megane Grah Kple, Julen Ariztia, Marion Leroux, Mathieu Moreau, Michael Claron, Maxime Cheveau, Adam Laouafa, Agnieszka Kownacka, Camille Petitot, John Simonet, Alexandre M. M. Dias, Sophie Poty, Charles Truillet, Bertrand Collin, Alexandra Oudot, Franck Denat   +16 more
wiley   +1 more source

A very long baseline interferometry sky survey [PDF]

, 1980
A systematic very long baseline interferometry (VLBI) sky survey, undertaken to find a suitable set of compact celestial radio sources from which a more complete VLBI reference frame can be constructed, discussed.
Morabito, D. D., Preston, R. A.
core  

The First LWA Swarm Calibrator Survey

The Astrophysical Journal
The LWA Swarm is an aperture synthesis telescope consisting of interconnected Long Wavelength Array (LWA) stations autonomously making joint observations.
C. A. Taylor, G. B. Taylor, J. Dowell, S. Pezzaioli   +3 more
doaj   +1 more source

Selective Modulation of OTUB1 Noncanonical Function via a bioPhosTAC Strategy

Advanced Science, EarlyView.
This work positions the versatile performance of the peptide‐based bioPhosTAC platform for dissecting phosphorylation‐dependent biology and expanding the scope of induced‐proximity technologies. We demonstrated that selective manipulation of a tyrosine phosphorylation site is sufficient to propagate coordinated cellular consequences.
Seung Un Seo, Seon Min Woo, Minhyeong Choi, Soeun Rhee, Simmyung Yook, Donghyuk Shin, Kwang‐Su Park, Taeg Kyu Kwon   +7 more
wiley   +1 more source

Scintillation Properties of PSR B1133+16 Measured with Very Long Baseline Interferometry

The Astrophysical Journal
The scintillation of pulsars reveals the small-scale structure of the interstellar medium. A powerful technique for characterizing the scintillating structures (screens) combines analysis of scintillation arcs and very long baseline interferometry (VLBI).
Ashley M. Stock, Fardin Syed, Marten H. van Kerkwijk, Rebecca Lin, Franz Kirsten, Ue-Li Pen   +5 more
doaj   +1 more source

Precessing Jet in the High-Redshift Blazar J0017+8135

Galaxies, 2016
The prominent flat-spectrum radio quasar J0017+8135 (S5 0014+81) at z = 3.366 is one of the most luminous active galactic nuclei (AGN) known. Its milliarcsecond-scale radio jet structure has been studied with very long baseline interferometry (VLBI ...
Kristóf Rozgonyi, Sándor Frey
doaj   +1 more source

AS‐TLC‐Based High‐Throughput Screening Integrated with CuAAC Optimization Strategy Facilitates the Rapid Discovery of YTHDC1 Inhibitor

Advanced Science, EarlyView.
We developed Affinity Selection Thin‐Layer Chromatography (AS‐TLC) as a method for high‐throughput screening (HTS) of compound mixtures. Furthermore, we integrated activity assays with AS‐TLC and identified a YTH domain‐containing protein 1 (YTHDC1) inhibitor. Building on this hit, we applied copper(I)‐catalyzed azide–alkyne cycloaddition (CuAAC) click
Mingchen Wang, Shuiping Fu, Ye Xu, Jia Gao, Jiwei Ren, Xu Yang, Hesong Xu, Ge Sun, Yanjie Li, Yanlin Wang, Lu Jin, Peijuan Chen, Ying Xu, Jianhao Li, Hua Lin, Chujiao Hu, Kaixian Chen, Huan Xiong, Cheng Luo, Shijie Chen   +19 more
wiley   +1 more source