Results 161 to 170 of about 164,812 (264)

A Supramolecular Nanoscavengers: Based “Cargo‐Exchange” Breaking Cholesterol Metabolic Dysregulation for Glioblastoma Therapy

Advanced Science, EarlyView.
Dysregulated cholesterol metabolism, driven by a complex array of mechanisms, is a defining characteristic of glioblastoma (GBM). In this study, supramolecular nanoscavengers are engineered by harnessing the intrinsic binding affinity between endogenous small‐molecule cholesterol and β‐cyclodextrin (β‐CD).
Zonghua Tian, Yun Chen, Jingyi Zhou, Shilin Zhang, Hongrui Fan, Xuwen Li, Tao Sun, Chen Jiang   +7 more
wiley   +1 more source

Peroxisome proliferator-activated receptor δ promotes very low-density lipoprotein-derived fatty acid catabolism in the macrophage

, 2006
Chih‐Hao Lee, Kihwa Kang, Isaac R. Mehl, Russell Nofsinger, William A. Alaynick, Ling-Wa Chong, John M. Rosenfeld, Ronald M. Evans   +7 more
openalex   +1 more source

Amelioration of Post‐Stroke Edema and Microcirculatory Dysfunction via Targeted AQP4 Inhibition While Preserving the Glymphatic System

Advanced Science, EarlyView.
Compared to untargeted therapy, the targeted nanocarrier, Angiopep‐2‐conjugated Lipid Nanoparticle (A‐LNP) loaded with TGN‐020 (TGN), selectively accumulated in stroke‐injured regions. It suppressed local aquaporin‐4 (AQP4) overexpression, thereby alleviating cerebral edema and hypoperfusion while preserving global glymphatic clearance.
Lei Jin, Zeyu Yang, Boyang Wei, Yu Wu, Longxiang Li, Jiaming Zhou, Xin Zhang, Fa Jin, Shixing Su, Yanchao Liu, Ran Li, Shenquan Guo, Xingwu Liu, Yu Cai, Hong Liu, Min Chen, Wenchao Liu, Chuanzhi Duan, Xifeng Li   +18 more
wiley   +1 more source

Comparison of serum very low-density lipoprotein concentrations during transition in primiparous and multiparous cows. [PDF]

J Vet Med Sci
Osada S, Chisato K, Fukumori R, Oikawa S.   +3 more
europepmc   +1 more source

The Pathogenic Role of Very Low Density Lipoprotein on Atrial Remodeling in the Metabolic Syndrome. [PDF]

Int J Mol Sci, 2020
Lee HC, Lin YH.
europepmc   +1 more source

Formation of N.EPSILON.-(Hexanonyl)lysine in Oxidized Human Very-low-density Lipoprotein.

, 2004
Hirofumi Arai, Yoji Kato, Kenji Fukunaga, Satoshi Mohri, Kazuyuki Nakamura   +4 more
openalex   +2 more sources

Immunoregulatory Properties of Human Plasma in Very Low Density Lipoproteins [PDF]

, 1977
Francis V. Chisari
openalex   +1 more source

From the Gut to the Brain: Microplastic‐Associated Neurovascular Dysfunction and Implications for Stroke Risk

Advanced Science, EarlyView.
Chronic oral exposure to microplastics may disrupt gut microbiota homeostasis and intestinal barrier integrity, potentially engaging the gut–brain axis and systemic inflammatory responses. These alterations may be associated with impaired blood–brain barrier function, cerebral microvascular dysfunction, and enhanced endothelial inflammation, pro ...
Hongxing Wang, Yujiao He, Pei Zou, Xiaoyi Wang, Gang Peng, Xiangying Deng   +5 more
wiley   +1 more source

Causal associations between intermediate very-low-density lipoprotein cholesterol-to-total lipids ratio and peptic ulcer: A bidirectional Mendelian randomization study. [PDF]

World J Clin Cases
Lin CM, Meng Q, Li YJ, Zhang SX, Luo QX, Dai ZY.   +5 more
europepmc   +1 more source

Associations of insulin resistance, inflammation and liver synthetic function with very low-density lipoprotein: The Cardiovascular Health Study

, 2015
Z. Gordon Jiang, Ian H. de Boer, Rachel H. Mackey, Majken K. Jensen, Michelle Lai, Simon C. Robson, Russell P. Tracy, Lewis H. Kuller, Kenneth J. Mukamal   +8 more
openalex   +1 more source