Results 1 to 10 of about 45,302 (266)

Postprandial lipoprotein metabolism: VLDL vs chylomicrons [PDF]

Clinica Chimica Acta, 2011
Since Zilversmit first proposed postprandial lipemia as the most common risk of cardiovascular disease, chylomicrons (CM) and CM remnants have been thought to be the major lipoproteins which are increased in the postprandial hyperlipidemia. However, it has been shown over the last two decades that the major increase in the postprandial lipoproteins ...
Nakajima, Katsuyuki, Nakano, Takamitsu, Tokita, Yoshiharu, Nagamine, Takeaki, Inazu, Akihiro, Kobayashi, Junji, Mabuchi, Hiroshi, Stanhope, Kimber L, Havel, Peter J, Okazaki, Mitsuyo, Ai, Masumi, Tanaka, Akira   +11 more
openaire   +4 more sources

VLDL receptor gene therapy for reducing atherogenic lipoproteins

Molecular Metabolism, 2023
Over the past 40 years, there has been considerable research into the management and treatment of atherogenic lipid disorders. Although the majority of treatments and management strategies for cardiovascular disease (CVD) center around targeting low-density lipoprotein cholesterol (LDL-C), there is mounting evidence for the residual CVD risk attributed
Krauss, Ronald M, Lu, Jonathan T, Higgins, Joseph J, Clary, Cathryn M, Tabibiazar, Ray   +4 more
openaire   +5 more sources

ApoAV Reduces Plasma Triglycerides by Inhibiting Very Low Density Lipoprotein-Triglyceride (VLDL-TG) Production and Stimulating Lipoprotein Lipase-mediated VLDL-TG Hydrolysis [PDF]

Journal of Biological Chemistry, 2004
ApoAV has been discovered recently as a novel modifier of triglyceride (TG) metabolism, but the pathways involved are currently unknown. To gain insight into the function of apoAV, adenovirus-mediated gene transfer of murine apoa5 to C57Bl/6 mice was employed.
Schaap, F.G., Rensen, P.C.N., Voshol, P.J., Vrins, C., Vliet, H.N. van der, Chamuleau, R.A.F.M., Havekes, L.M., Groen, A.K., Dijk, K.W. van   +8 more
openaire   +3 more sources

Heparin binding triggers human VLDL remodeling by circulating lipoprotein lipase: Relevance to VLDL functionality in health and disease

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2022
Hydrolysis of VLDL triacylglycerol (TG) by lipoprotein lipase (LpL) is a major step in energy metabolism and VLDL-to-LDL maturation. Most functional LpL is anchored to the vascular endothelium, yet a small amount circulates on TG-rich lipoproteins. As circulating LpL has low catalytic activity, its role in VLDL remodeling is unclear. We use pre-heparin
Jayaraman, S, Perez, A, Minambres, I, Sanchez-Quesada, JL, Gursky, O   +4 more
openaire   +4 more sources

Very low-density lipoprotein (VLDL)-induced signals mediating aldosterone production [PDF]

Journal of Endocrinology, 2017
Aldosterone, secreted by the adrenal zona glomerulosa, enhances sodium retention, thus increasing blood volume and pressure. Excessive production of aldosterone results in high blood pressure and contributes to cardiovascular and renal disease, stroke and visual loss.
Ying-Ying, Tsai, William E, Rainey, Wendy B, Bollag   +2 more
openaire   +2 more sources

Hepatic Golgi lipoproteins: precursors to plasma lipoproteins in hypercholesterolemic rats

Journal of Lipid Research, 1982
Two classes of nascent lipoproteins can be isolated from Golgi apparatus-rich fractions of liver from hypercholesterolemic rats. Golgi very low density lipoproteins (VLDL, d less than 1.006 g/ml) are enriched in cholesteryl esters and are similar in many
L L Swift, P D Soulé, V S LeQuire
doaj   +1 more source

Postprandial apoE isoform and conformational changes associated with VLDL lipolysis products modulate monocyte inflammation. [PDF]

, 2012
ObjectivePostprandial hyperlipemia, characterized by increased circulating very low-density lipoproteins (VLDL) and circulating lipopolysaccharide (LPS), has been proposed as a mechanism of vascular injury.
Altman, Robin, Budamagunta, Madhu S., den Hartigh, Laura J., Hutchinson, Romobia, Lagerstedt, Jens,, Lund University., Lund University., Petrlova, Jitka,, Rutledge, John C., Tetali, Sarada D., Voss, John C.   +10 more
core   +3 more sources

Biosynthesis of lymph and plasma lipoprotein apoproteins by isolated perfused rat liver and intestine

Journal of Lipid Research, 1973
The ability of rat intestine and liver to synthesize the various apoproteins of plasma lipoproteins was investigated. After the individual isolated organs were perfused with blood containing [3H]lysine, chylomicrons plus very low density lipoproteins ...
Herbert G. Windmueller, Peter N. Herbert, Robert I. Levy   +2 more
doaj   +1 more source

Relation of hyperlipidemia in serum and loss of high density lipoproteins in urine in the nephrotic syndrome [PDF]

, 1987
The mechanism leading to hyperlipidemia in the nephrotic syndrome is not fully understood but may be related in part to loss of high density lipoproteins in the urine of patients with nephrosis.
Appel, Baxter, Baxter, Chopra, De Mendoza, Eggstein, Felts, Gherardi, Gherardi, Havel, Jüngst, Jüngst, Kashyap, Klahr, Lopes-Virella, Newmark, Ohta, Röschlau, Sachs, Sata, Tamm, Wada, Weichselbaum   +22 more
core   +1 more source

Characterization of a very-low-density lipoprotein (VLDL)-associated cytotoxic factor [PDF]

British Journal of Cancer, 1981
A VLDL-associated cytotoxic factor was isolated from sera of pregnant rats and characterized. The inhibitory effect of this factor on the macromolecular synthesis of rat prostate adenocarcinoma cells (PA-III) was also examined. VLDL (Sf 20-400) was subfractionated by differential ultracentrifugal flotation and the Sf 100-400 fraction was associated ...
S Y, Chan, M, Pollard
openaire   +2 more sources