Results 11 to 20 of about 45,302 (266)

Emerging Evidence of Pathological Roles of Very-Low-Density Lipoprotein (VLDL)

International Journal of Molecular Sciences, 2022
Embraced with apolipoproteins (Apo) B and Apo E, triglyceride-enriched very-low-density lipoprotein (VLDL) is secreted by the liver into circulation, mainly during post-meal hours. Here, we present a brief review of the physiological role of VLDL and a systemic review of the emerging evidence supporting its pathological roles.
Jih-Kai Huang, Hsiang-Chun Lee
openaire   +4 more sources

Triglyceride Rich Lipoprotein -LPL-VLDL Receptor and Lp(a)-VLDL Receptor Pathways for Macrophage Foam Cell Formation

Journal of Atherosclerosis and Thrombosis, 2017
Very low-density lipoprotein (VLDL) receptor is a member of the low-density lipoprotein (LDL) receptor family. It binds triglyceride rich lipoprotein (TGRL) but not LDL, because it recognizes apolipoprotein (apo)E only but not apoB. The VLDL receptor functions as a peripheral lipoprotein receptor in concert with lipoprotein lipase (LPL) in heart ...
openaire   +5 more sources

The effect of hypertension, diabetes, and smoking on the levels of some biochemical parameters in chronic renal failure patients

Tikrit Journal of Pure Science, 2019
This study has been acomblished between December 2016 and September  2017 which included 70 patients with chronic renal failure who attended at Al-yarmuke teaching hospital in Baghdad with25 healthy individual as control.
Noor H. Ali, Firas T. Maher, Mohammad M. F. Al-Halbosiy   +2 more
doaj   +1 more source

An integrated mathematical model of cellular cholesterol biosynthesis and lipoprotein metabolism [PDF]

, 2018
Cholesterol regulation is an important aspect of human health. In this work we bring together and extend two recent mathematical models describing cholesterol biosynthesis and lipoprotein endocytosis to create an integrated model of lipoprotein ...
Pool, Frances, Sweby, Peter K., Tindall, Marcus J.   +2 more
core   +2 more sources

Apolipoprotein F is reduced in humans with steatosis and controls plasma triglyceride‐rich lipoprotein metabolism

Hepatology, EarlyView., 2022
Hepatic APOF transcript levels correlate inversely with plasma TG and hepatic steatosis in humans. ApoF expression in mice promotes VLDL‐TG production and lipoprotein remnant clearance in mice. Abstract Background NAFLD affects nearly 25% of the global population. Cardiovascular disease (CVD) is the most common cause of death among patients with NAFLD,
Audrey Deprince, Nathalie Hennuyer, Sander Kooijman, Amanda C. M. Pronk, Eric Baugé, Viktor Lienard, An Verrijken, Eveline Dirinck, Luisa Vonghia, Eloïse Woitrain, Niels J. Kloosterhuis, Eléonore Marez, Pauline Jacquemain, Justina C. Wolters, Fanny Lalloyer, Delphine Eberlé, Sandrine Quemener, Emmanuelle Vallez, Anne Tailleux, Mostafa Kouach, Jean‐Francois Goossens, Violeta Raverdy, Bruno Derudas, Jan Albert Kuivenhoven, Mikaël Croyal, Bart van de Sluis, Sven Francque, François Pattou, Patrick C. N. Rensen, Bart Staels, Joel T. Haas   +30 more
wiley   +1 more source

Effect of very low-density lipoproteins on lipid transfer in incubated serum

Journal of Lipid Research, 1965
Incubation of human serum solutions low in glyceride content for 16 hr resulted in a net increase of cholesterol esters in all three major human serum lipoprotein classes, namely the very low-density lipoproteins of d < 1.006 (VLDL), low-density ...
A.V. Nichols, L. Smith
doaj   +1 more source

Unpacking and understanding the impact of proprotein convertase subtilisin/kexin type 9 inhibitors on apolipoprotein B metabolism [PDF]

, 2017
No abstract ...
Packard, Chris J.
core   +1 more source

Loss of hepatic SMLR1 causes hepatosteatosis and protects against atherosclerosis due to decreased hepatic VLDL secretion

Hepatology, EarlyView., 2022
The role of SMLR1 in lipid metabolism (high fat + cholesterol diet in mice) Abstract Background and Aims The assembly and secretion of VLDL from the liver, a pathway that affects hepatic and plasma lipids, remains incompletely understood. We set out to identify players in the VLDL biogenesis pathway by identifying genes that are co‐expressed with the ...
Willemien van Zwol, Antoine Rimbert, Justina C. Wolters, Marieke Smit, Vincent W. Bloks, Niels J. Kloosterhuis, Nicolette C. A. Huijkman, Mirjam H. Koster, Umesh Tharehalli, Simon M. de Neck, Colin Bournez, Marceline M. Fuh, Jeroen Kuipers, Sujith Rajan, Alain de Bruin, Henry N. Ginsberg, Gerard J. P. van Westen, M. Mahmood Hussain, Ludger Scheja, Joerg Heeren, Philip Zimmerman, Bart van de Sluis, Jan Albert Kuivenhoven   +22 more
wiley   +1 more source

Lipoprotein metabolism in the suckling rat: characterization of plasma and lymphatic lipoproteins.

Journal of Lipid Research, 1983
Suckling rat plasma contains (in mg/dl): chylomicrons (85 +/- 12); VLDL (50 +/- 6); LDL (200 +/- 23); HDL1 (125 +/- 20); and HDL2 (220 +/- 10), while lymph contains (in mg/dl): chylomicrons (9650 +/- 850) and VLDL (4570 +/- 435) and smaller amounts of ...
G J Fernando-Warnakulasuriya, M L Eckerson, W A Clark, M A Wells   +3 more
doaj   +1 more source

Macrophages take up VLDL-sized emulsion particles through caveolae-mediated endocytosis and excrete part of the internalized triglycerides as fatty acids.

PLoS Biology, 2022
Triglycerides are carried in the bloodstream as part of very low-density lipoproteins (VLDLs) and chylomicrons, which represent the triglyceride-rich lipoproteins.
Lei Deng, Frank Vrieling, Rinke Stienstra, Guido J Hooiveld, Anouk L Feitsma, Sander Kersten   +5 more
doaj   +1 more source