Harnessing Viral Proteases for Cellular and Molecular Engineering
Chemistry–Methods, EarlyView.Engineered viral proteases (VIPs) provide programmable control of protein function with high specificity and low toxicity. Integrated with chemogenetic and optogenetic modules, these VIP systems enable logic gate manipulation for targeted regulation of cell signaling, gene expression, protein secretion, and degradation, thereby offering versatile ...
Mingguang Cui +2 more
wiley +1 more source
Phosphatidylinositol (3,4,5)-trisphosphate binds to sortilin and competes with neurotensin: Implications for very low density lipoprotein binding. [PDF]
Biochem Biophys Res Commun, 2016 Sparks RP +7 more
europepmc +1 more source
Model‐Informed Drug Development Applications and Opportunities in mRNA‐LNP Therapeutics
Clinical Pharmacology &Therapeutics, EarlyView.The utilization of lipid nanoparticles (LNP) for encapsulating mRNA has revolutionized the field of therapeutics, enabling the rapid development of COVID‐19 vaccines and cancer vaccines. However, the clinical development of mRNA‐LNP therapeutics faces numerous challenges due to their complex mechanisms of action and limited clinical experience.
Jiawei Zhou +6 more
wiley +1 more source
In Vitro Analysis of the Very-Low Density Lipoprotein Export from the Trans-Golgi Network. [PDF]
Curr Protoc Cell Biol, 2015 Siddiqi SA.
europepmc +1 more source
Photochemistry of Resveratrol: Beyond the Reactivity of Metal‐Free Porphyrins Immobilized on Lignin
ChemPhotoChem, EarlyView.Resveratrol photochemistry with singlet oxygen is examined at 450 nm using blue‐LED irradiation and various homogeneous and heterogeneous photosensitizers. Products of CC bond cleavage, electrocyclic ring closure, and [4 + 2] cycloaddition are identified.
Elisa De Marchi +8 more
wiley +1 more source
Predictors of Subclinical Inflammatory Obesity: Plasma Levels of Leptin, Very Low-Density Lipoprotein Cholesterol and CD14 Expression of CD16+ Monocytes. [PDF]
Obes Facts, 2017 Leite F +6 more
europepmc +1 more source
Drug Testing and Analysis, EarlyView.Scenarios of drug exposure and administration as well as detection assays for drugs and methods of sports doping published between 2023 and 2024 are critically reviewed and evaluated in context with the Prohibited List 2024 as established by the World Anti‐Doping Agency.
Mario Thevis +2 more
wiley +1 more source
Elevated Levels of Very Low-density Lipoprotein Cholesterol Independently Associated with In-stent Restenosis in Diabetic Patients after Drug-eluting Stent Implantation. [PDF]
Chin Med J (Engl), 2017 Qin Z +8 more
europepmc +1 more source
Developmental Dynamics, EarlyView.Abstract Background The emergence of multicellularity in animals marks a pivotal evolutionary event, which was likely enabled by molecular innovations in the way cells adhere and communicate with one another. β‐Catenin is significant to this transition due to its dual role as both a structural component in the cadherin–catenin complex and as a ...
Brian M. Walters +5 more
wiley +1 more source
Interaction of Fibrin with the Very Low-Density Lipoprotein (VLDL) Receptor: Further Characterization and Localization of the VLDL Receptor-Binding Site in Fibrin βN-Domains. [PDF]
Biochemistry, 2017 Yakovlev S, Medved L.
europepmc +1 more source