Results 51 to 60 of about 529,645 (391)
Kinetic Pathway and Micromechanics of Vesicle Fusion/Fission [PDF]
arXiv, 2023 Despite the wide existence of vesicles in living cells as well as their important applications like drug-delivery, the underlying mechanism of vesicle fusion/fission remains under debate. Here, we develop a constrained self-consistent field theory (SCFT) which allows tracking the shape evolution and free energy as a function of center-of-mass ...
arxiv
Cross-stream migration of a vesicle in vortical flows [PDF]
, 2022 We use numerical simulations to systematically investigate the vesicle dynamics in two-dimensional (2D) Taylor-Green vortex flow in the absence of inertial forces. Vesicles are highly deformable membranes encapsulating an incompressible fluid and they serve as numerical and experimental proxies for biological cells such as red blood cells.
arxiv +1 more source
Journal of Cell Biology, 1973 When the nerves of isolated frog sartorius muscles were stimulated at 10 Hz, synaptic vesicles in the motor nerve terminals became transiently depleted.
J. Heuser, T. Reese
semanticscholar +1 more source
Phenotypic continuum of NFU1‐related disorders
Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 2025-2035, December 2022., 2022 Abstract Bi‐allelic variants in Iron–Sulfur Cluster Scaffold (NFU1) have previously been associated with multiple mitochondrial dysfunctions syndrome 1 (MMDS1) characterized by early‐onset rapidly fatal leukoencephalopathy. We report 19 affected individuals from 10 independent families with ultra‐rare bi‐allelic NFU1 missense variants associated with a
Rauan Kaiyrzhanov +45 more
wiley +1 more source
Frontiers in Veterinary Science, 2022 Infections caused by helminths are responsible for severe public health problems and economic burden on continental scale. Well-timed and precise diagnosis of helminth infections is critical for taking by appropriate approaches for pathogen control ...
Hanif Ullah +10 more
doaj +1 more source
The synaptic vesicle protein SV2A is the binding site for the antiepileptic drug levetiracetam.
Proceedings of the National Academy of Sciences of the United States of America, 2004 Here, we show that the synaptic vesicle protein SV2A is the brain binding site of levetiracetam (LEV), a new antiepileptic drug with a unique activity profile in animal models of seizure and epilepsy. The LEV-binding site is enriched in synaptic vesicles,
B. Lynch +6 more
semanticscholar +1 more source
Vascular endothelial‐cadherin as a marker of endothelial injury in preclinical Alzheimer disease
Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 1926-1940, December 2022., 2022 Abstract Objective Endothelial dysfunction is an early and prevalent pathology in Alzheimer disease (AD). We here investigate the value of vascular endothelial‐cadherin (VEC) as a cerebrospinal fluid (CSF) marker of endothelial injury in preclinical AD.
Rawan Tarawneh +5 more
wiley +1 more source
Preparation of Liposomes from Soy Lecithin Using Liquefied Dimethyl Ether
Foods, 2021 We investigated a method to prepare liposomes; soy lecithin was dissolved in liquefied dimethyl ether (DME) at 0.56 MPa, which was then injected into warm water. Liposomes can be successfully prepared at warm water temperatures above 45 °C.
Hideki Kanda +3 more
doaj +1 more source
FEBS Letters, EarlyView.The glacier ice worm Mesenchytraeus solifugus survives year‐round at 0 °C. Its ATP6 subunit, which forms a regulatory component of the proton pore in mitochondrial ATP synthase, has a carboxy‐terminal extension not found in any other organism examined to date. Here, we show that fusion of this extension to the homologous AtpB protein in E. coli results
Truman Dunkley +2 more
wiley +1 more source
Diseases, 2021 Acute myeloid leukemia (AML) is an aggressive bone marrow malignancy, and non-leukemic stromal cells (including mesenchymal stem cells, MSCs) are involved in leukemogenesis and show AML-supporting effects.
Elise Aasebø +8 more
doaj +1 more source