Results 121 to 130 of about 520,160 (311)

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

Vesicles and lamella: outcome of the changing formation path of a sodium N-lauroylsarcosinate hydrate/1-decanol/water system

, 2012
Vesicles are closed bilayers that enclose a part of the continuous phase inside the core. In spherical shape, they attain the minimum free energy state.
Nasima Akter, Mohammad I. H. Reza, Faizal Mohamed, Shahidan Radiman   +3 more
core  

Isolation of Extracellular Vesicles from Stem Cells

, 2017
Transplanted induced pluripotent stem cells (IPSC) and embryonic stem cells (ESC) exhibit enhanced survival in ischemic tissues and promote survival of neighboring cells via paracrine effects.
Liu, Yutao, Yutao Liu, Kim, Il-Man, Neal L. Weintraub, Weintraub, Neal L., Chengwei Ju, Tang, Yaoliang, Genshan Ma, Il-man Kim, Yaoliang Tang, Ju, Chengwei, Hong Yu, Yongjun Li, Li, Yongjun, Zixin Chen, Yu, Hong, Yan Shen, Chen, Zixin, Shen, Yan, Ma, Genshan   +19 more
core   +1 more source

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source

Pharmaceutical development of etodolac transfersomal gel for topical drug delivery system in rheumatoid arthritis

Journal of Applied Pharmaceutical Research
Background: Transferosomes provide delivery of the drug into systemic circulation via the skin as a topical delivery system. So, this study started with the objective of formulating Etodolac transfersomal gel to enhance its skin permeation.
Ashwini Bachhav, Prashant L Pingale, Chandrashekhar D Upasani   +2 more
doaj   +1 more source

Peripheral Neutrophil Activation and Extracellular Trap Formation in Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
Markers of neutrophil activation are increased in plasma during ALS, and markers of NET formation associate with ALS survival. ABSTRACT Objectives Peripheral neutrophil levels in amyotrophic lateral sclerosis (ALS) inversely correlate with survival, suggesting a role for neutrophils in disease progression.
Lillia A. Baird, Haley McQuown, Jihyun Park, Samuel J. Teener, Ian F. Webber‐Davis, Andrew D. Carter, Dae‐Gyu Jang, Eva L. Feldman, Stephen A. Goutman, Benjamin J. Murdock   +9 more
wiley   +1 more source

Fluorogenic Biosensing with Tunable Polydiacetylene Vesicles

Biosensors
Polydiacetylenes (PDAs) are conjugated polymers that are well known for their colorimetric transition from blue to red with the application of energetic stimulus. Sensing platforms based on polymerized diacetylene surfactant vesicles and other structures
John S. Miller, Tanner J. Finney, Ethan Ilagan, Skye Frank, Ye Chen-Izu, Keishi Suga, Tonya L. Kuhl   +6 more
doaj   +1 more source

Beyond basic characterization and omics : Immunomodulatory roles of platelet-derived extracellular vesicles unveiled by functional testing

Renowned for their role in haemostasis and thrombosis, platelets are also increasingly recognized for their contribution in innate immunity, immunothrombosis and inflammatory diseases.
Oxvig, Claus,, Kari, Otto K., Kari, Otto, Masood Kamali‐Moghaddam, Federico, Antonio,, Siljander, Pia R.M., Rikke Halse Østergaard, Kamali-Moghaddam, Masood,, Laitinen, Saara, Eble, Johannes A., Kjaer-Sorensen, Kasper, Hayashi, Yuya, Kasper Kjaer‐Sorensen, Joseph Ndika, Palviainen, Mari, Greco, Dario,, Juan M. Falcon‐Perez, Mari Palviainen, Laitinen, Saara,, Saara Laitinen, Palviainen, Mari,, Claus Oxvig, Aransay, Ana M.,, Federico, Antonio, Maaninka, Katariina, Ana M. Aransay, Falcon-Perez, Juan M., Katariina Maaninka, Pia R.‐M. Siljander, Kamali-Moghaddam, Masood, Aransay, Ana M., Eble, Johannes A.,, Halse Østergaard, Rikke,, Falcon-Perez, Juan M.,, Eble, Johannes, Butt, Umar, Butt, Umar,, Østergaard, Rikke Halse, Greco, Dario, Umar Butt, Oxvig, Claus, Ndika, Joseph,, Kjaer-Sorensen, Kasper,, Johannes A. Eble, Dario Greco, Ndika, Joseph, Johanna Puutio, Puutio, Johanna, Puutio, Johanna,, Ostergaard, Rikke, Yuya Hayashi, Kari, Otto K.,, Otto K. Kari, Antonio Federico, Siljander, Pia, Aransay, Ana, Hayashi, Yuya,, Maaninka, Katariina,, Halse Østergaard, Rikke, Siljander, Pia R. -M., Siljander, Pia R. -M.,   +60 more
core   +1 more source

Plasma EV Proteomics Identifies ECM Remodeling and Inflammatory Proteins LUM and C7 as Candidate Biomarkers in FSHD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral muscular dystrophy (FSHD) is one of the most debilitating and common muscular dystrophies. Despite its severity, no approved therapy exists for FSHD patients. However, several therapeutic candidates are currently under development, and some have recently entered clinical trials, marking the need for reliable ...
Mustafa Bilal Bayazit, Chiranth K. Nagaraj, Jackson S. Newell, Kim Truc Nguyen, Xilal Y. Rima, Jacob Doon‐Ralls, Eduardo Reátegui, Jeffrey M. Statland, Rabi Tawil, Kevin M. Flanigan, Scott Q. Harper, Nizar Y. Saad   +11 more
wiley   +1 more source