Results 161 to 170 of about 27,516 (300)

Assessing the Vulnerability of an Inuit Archaeological Site in a Changing Periglacial Environment: A Novel Multimethod Geophysical Approach in Arctic Geoarchaeology

open access: yesArchaeometry, EarlyView.
ABSTRACT With northern regions warming at twice the global rate, assessing the state of archaeological sites in these areas is critically important. In this study, we used a multimethod geophysical approach (ERT, GPR, and EMI) to characterize the current geocryological conditions of an Inuit archaeological site on South Aulatsivik Island (Labrador ...
Rachel Labrie   +5 more
wiley   +1 more source

What Difference Does Language Make? Comparing Systematic Evidence Reviews of Vietnamese and English Language Literatures on Climate Change and the Health of Outdoor Workers

open access: yesArea, EarlyView.
Short Abstract This paper compares two systematic literature reviews—one in English and one in Vietnamese—to examine how language shapes the production and framing of knowledge on climate change and health. It highlights significant differences in methods, assumptions and policy framings, and argues that linguistic boundaries are not just technical ...
Anh Ngoc Vu   +4 more
wiley   +1 more source

Mitochondrial Ca2+ overload is a pivotal risk factor for lethal ventricular arrhythmias due to the oxidation of mitochondrial respirasome and energetic failure

open access: yesBritish Journal of Pharmacology, EarlyView.
The data that support the findings of this study are available from the corresponding author upon reasonable request. Some data may not be made available because of privacy or ethical restrictions. Background and Purpose Ventricular arrhythmias are a leading cause of death among patients with cardiovascular diseases and are associated with elevated ...
Felipe de Jesús Salazar‐Ramírez   +13 more
wiley   +1 more source

Molecular basis for a pore block of Tentonin 3 expressed in HEK293 cells by a conopeptide, NMB‐1

open access: yesBritish Journal of Pharmacology, EarlyView.
Background and Purpose Tentonin 3 (TTN3/TMEM150C) is a mechanosensitive ion channel that plays critical roles in mechanotransduction processes. TTN3 forms a tetramer with a predicted rectangular shape and a central pore. A conotoxin ρ‐TIA and its synthetic analog, noxious mechanosensation blocker 1 (NMB‐1), were initially developed to inhibit slowly ...
Sujin Lim   +10 more
wiley   +1 more source

Biallelic RFC1 Expansions Are a Rare Cause of Early‐Onset and Familial Parkinson's Disease

open access: yesClinical Genetics, EarlyView.
Biallelic pathogenic expansions in RFC1 contribute to the genetic etiology of PD, with a frequency similar to that of other known autosomal recessive PD genes. RFC1‐positive PD is currently not clinically distinguishable from RFC1‐negative PD, but genetic background may play a role in future therapies or other interventions.
Anja Kovanda   +11 more
wiley   +1 more source

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