Results 171 to 180 of about 810 (254)
Defining the polycystin pharmacophore through high‐throughput screening and computational biophysics
British Journal of Pharmacology, EarlyView.An unbiased high throughput electrophysiology screen identifies potent PKD2L1 channel inhibitors with divergent chemical composition that bind to pore fenestration receptors and stabilise their inactivated state. Abstract Background and Purpose Polycystins (PKD2, PKD2L1) are voltage‐gated and Ca2+‐modulated members of the TRP family of ion channels ...
Eduardo Guadarrama +2 more
wiley +1 more source
Re‐make, re‐model: evolution and development of vertebrate cranial lateral lines
Biological Reviews, EarlyView.ABSTRACT Lateral lines are placodally derived mechanosensory systems on the heads and trunks of many aquatic vertebrates. There is evidence of lateral lines in the earliest known vertebrate fossils, and they exist in organisms with widely different craniofacial morphologies – including the presence or absence of jaws, external or internal nostrils, and
Vishruth Venkataraman +3 more
wiley +1 more source
Vestibular function testing in individuals with cognitive impairment: our experience with sixty participants [PDF]
, 2016 Aisha Harun +3 more
openalex +1 more source
Clinical Genetics, EarlyView.Our mouse model with a c.259G>A transition in PRPS1 showed a significant decrease in the number of hair cells and SGN counts at 48 weeks of age and a reduction in Prps1 enzymatic activity in the KI mouse. This model will serve as a valuable tool for developing therapeutic strategies.
Denise Yan +6 more
wiley +1 more source
Clinical Oral Implants Research, EarlyView.ABSTRACT Objectives To analyze the clinical, radiographic, and microbiological changes around implants with a multiphosphonate‐treated surface, prosthetically loaded with two different protocols after 5 years of functional loading. Material and Methods A randomized clinical trial was designed to initiate prosthetic loading over single dental implants ...
Pablo Galindo‐Moreno +8 more
wiley +1 more source
Clinical Oral Implants Research, EarlyView.ABSTRACT Objectives This randomized clinical study compared the profilometric measurements of the buccal tissue volume at sites augmented using a volume‐stable collagen matrix (VCMX) or connective tissue graft (CTG) simultaneously to implant placement in the presence of small buccal bone dehiscence (SBBD ≤ 3 mm).
Francesco Ferrarotti +5 more
wiley +1 more source
Clinical Oral Implants Research, EarlyView.ABSTRACT Aim To compare the dimensional outcomes of horizontal augmentation with the retentive‐flap technique using particulate and cross‐linked collagenated bone substitutes. Materials and Methods This two‐centre, two‐arm randomized clinical trial investigated 69 subjects: 34 in the particulate group and 35 in the collagenated group.
Ji‐Young Jung +5 more
wiley +1 more source
The Role of Vestibular Function Tests in Patients with Sudden Sensorineural Hearing Loss Who Have Subclinical Vestibular Dysfunction [PDF]
, 2013 Seung Gon Jung +4 more
openalex +1 more source