Results 41 to 50 of about 117,564 (348)
Bilirubin Targeting WNK1 to Alleviate NLRP3‐Mediated Neuroinflammation
At physiological concentrations, bilirubin binds to the kinase domain of WNK1, thereby augmenting its activity and facilitating the phosphorylation of downstream SPAK/OSR1. This phosphorylation inhibits KCC2 activity, leading to elevate intracellular chloride levels in neurons.
Linfei Mao+14 more
wiley +1 more source
The vestibular contribution to the head direction cells signal and navigation
Spatial learning and navigation depend on neural representations of location and direction within the environment. These representations, encoded by place cells and head direction cells, respectively, are dominantly controlled by visual cues, but ...
Jeffrey S Taube, Ryan M. Yoder
doaj +1 more source
Vestibular System and Self-Motion [PDF]
Detection of the state of self-motion, such as the instantaneous heading direction, the traveled trajectory and traveled distance or time, is critical for efficient spatial navigation. Numerous psychophysical studies have indicated that the vestibular system, originating from the otolith and semicircular canals in our inner ears, provides robust ...
Zhixian Cheng, Yong Gu
openaire +3 more sources
Detection thresholds of macaque otolith afferents [PDF]
The vestibular system is our sixth sense and is important for spatial perception functions, yet the sensory detection and discrimination properties of vestibular neurons remain relatively unexplored.
Angelaki, Dora E+2 more
core +2 more sources
Current preclinical studies of AAV‐mediated gene therapy explore different strategies based on the characteristics of inner ear diseases. For genetic hearing loss, approaches include the replacement of a “good gene,” removal of a “bad gene,” or direct correction of mutations through base editing.
Fan Wu+7 more
wiley +1 more source
AAVR Expression is Essential for AAV Vector Transduction in Sensory Hair Cells
Decreased sensitivity to AAV vector transduction in the outer hair cells (OHCs) of adult mice is primarily attributed to reduction of AAVR (Kiaa0319l; Au040320). Knockout of AAVR reduces AAV vector transduction efficiency in both inner hair cells (IHCs) and OHCs in neonatal mice.
Fan Wu+8 more
wiley +1 more source
REHABILITATION OF PATIENTS WITH VESTIBULAR DISORDERS
Vestibular disorders are one of the most common causes of dizziness and loss of stability. Rehabilitation of patients with vestibular disorders is based on identifying the underlying disease and its effective treatment.
L. M. Antonenko, V. A. Parfenov
doaj +1 more source
Wei et al. establish a hair cell‐specific conditional knockout mouse model (Atp6v1b2fl/fl;Atoh1Cre/+), and demonstrate the importance of Atp6v1b2 for hair cell through maintaining the survival of lysosomes. A single administration of AAV‐ie‐Eh3‐mAtp6v1b2 through scala media at P0‐P2 realizes function compensation and restores hearing and balance ...
Gege Wei+15 more
wiley +1 more source
Electrocochleography (EcochG), incorporating the Cochlear Microphonic (CM), the Summating Potential (SP), and the cochlear Compound Action Potential (CAP), has been used to study cochlear function in humans and experimental animals since the 1930s ...
Daniel J. Brown+2 more
doaj +1 more source
Development of a dynamic virtual reality model of the inner ear sensory system as a learning and demonstrating tool [PDF]
In order to keep track of the position and motion of our body in space, nature has given us a fascinating and very ingenious organ, the inner ear. Each inner ear includes five biological sensors - three angular and two linear accelerometers - which ...
Gourinat, Yves+2 more
core +3 more sources