Block of NMDA receptor channels by endogenous neurosteroids: implications for the agonist induced conformational states of the channel vestibule [PDF]
Scientific Reports, 2015 N-methyl-D-aspartate receptors (NMDARs) mediate synaptic plasticity and their dysfunction is implicated in multiple brain disorders. NMDARs can be allosterically modulated by numerous compounds, including endogenous neurosteroid pregnanolone sulfate ...
Vojtech Vyklicky +2 more
exaly +3 more sources
Age-Related Changes in the Cochlea and Vestibule: Shared Patterns and Processes [PDF]
Frontiers in Neuroscience, 2021 Both age-related hearing loss (ARHL) and age-related loss in vestibular function (ARVL) are prevalent conditions with deleterious consequences on the health and quality of life. Age-related changes in the inner ear are key contributors to both conditions.
Vasiliki Georgia Paplou +2 more
openalex +2 more sources
Multidisciplinary approach to nose vestibule malignancies: setting new standards
Acta Otorhinolaryngologica Italica, 2021 SUMMARY Nose vestibule malignancies, mainly SCCs, are considered rare neoplasms. In the present paper, we review the current state of the art concerning classification and treatment, and describe current evidence supporting a paradigm shift.
Francesco Bussu +2 more
exaly +2 more sources
An Accessroy tragus on the nasal vestibule: A case report
Otolaryngology Case Reports, 2021 An accessory tragus is a congenital defect involving malformation of the tragus. Rarely, it can be found in the nasal vestibule, where it can cause functional airway obstruction.
Ahmed Alsayed +2 more
doaj +2 more sources
The gods bestow life. New material for the study of divine processions in the Vestibule of the Chapel of Hatshepsut in Deir el-Bahari [PDF]
Polish Archaeology in the Mediterranean, 2018 The decoration of the Vestibule of the Chapel of Hatshepsut in the queen’s temple in Deir el-Bahari resembles the decoration of the square antechamber known from the pyramid temples of the Old and Middle Kingdoms.
Edyta Kopp
doaj +2 more sources
eLife, 2020 Pentameric ligand-gated ion channels (pLGICs) or Cys-loop receptors are involved in fast synaptic signaling in the nervous system. Allosteric modulators bind to sites that are remote from the neurotransmitter binding site, but modify coupling of ligand ...
Marijke Brams +12 more
doaj +2 more sources
Dissociated responses to caloric and head impulse stimulation in a case of isolated vestibule-lateral semicircular canal dysplasia [PDF]
Acta Oto-Laryngologica Case Reports, 2018 Isolated vestibule-lateral semicircular canal dysplasia (LSCCD) is one of the most common inner ear malformations. We present a case of a 59-year-old patient with right vestibule-lateral canal dysplasia and a history of spontaneous vertigo spells without
Ricardo Wegmann-Vicuña +5 more
doaj +2 more sources
Drug-bound outward-facing conformation of a heterodimeric ABC exporter suggests a putative mechanism of drug translocation [PDF]
Nature CommunicationsMultidrug transport by ATP binding cassette (ABC) exporters entails a mechanism to modulate drug affinity across the transport cycle. Here, we combine cryo-EM and molecular dynamics (MD) simulations to illuminate a lipid-competition mechanism to drive ...
Qingyu Tang +5 more
doaj +2 more sources
“Hidden in Plain Sight”: A Descriptive Review of Laryngeal Vestibule Closure
Dysphagia, 2018 Alicia Vose
exaly +2 more sources