Results 41 to 50 of about 71,569 (397)

Precision medicine: a new era for inner ear diseases

Frontiers in Pharmacology
The inner ear is the organ responsible for hearing and balance. Inner ear dysfunction can be the result of infection, trauma, ototoxic drugs, genetic mutation or predisposition. Often, like for Ménière disease, the cause is unknown.
Elisa Tavazzani, Elisa Tavazzani, Paolo Spaiardi, Paolo Spaiardi, Donatella Contini, Giulio Sancini, Giulio Sancini, Giancarlo Russo, Sergio Masetto   +8 more
doaj   +1 more source

An Accessroy tragus on the nasal vestibule: A case report

Otolaryngology Case Reports, 2021
An accessory tragus is a congenital defect involving malformation of the tragus. Rarely, it can be found in the nasal vestibule, where it can cause functional airway obstruction.
Ahmed Alsayed, Hisham Alkhalidi, Abdulmajeed Zakzouk   +2 more
doaj   +1 more source

Intralabyrinthine Vestibular Schwannoma Responsive to Intratympanic Gentamicin Treatment [PDF]

, 2017
Intralabyrinthine schwannoma (ILS) is a rare benign tumor that affects the ends of cochlear and vestibular nerves. In a majority of the cases, it occurs with unilateral progressive sensorineural hearing loss.
Barbara, Maurizio, Covelli, Edoardo, Filippi, Chiara, Marrone, V, Monini, Simonetta, Tarentini, S, Volpini, Luigi   +6 more
core   +1 more source

microRNAs: the art of silencing in the ear

EMBO Molecular Medicine, 2012
MicroRNAs (miRNAs) are small non‐coding RNAs that regulate gene expression through the RNA interference (RNAi) pathway and by inhibition of mRNA translation.
Anya Rudnicki, Karen B. Avraham
doaj   +1 more source

Cotranslational folding of proteins on the ribosome.

, 2020
Many proteins in the cell fold cotranslationally within the restricted space of the polypeptide exit tunnel or at the surface of the ribosome. A growing body of evidence suggests that the ribosome can alter the folding trajectory in many different ways ...
Liutkute, M., Rodnina, M., Samatova, E.
core   +1 more source

Mapping a novel positive allosteric modulator binding site in the central vestibule region of human P2X7

Scientific Reports, 2019
P2X7 receptors are important in the regulation of inflammatory responses and immune responses to intracellular pathogens such as Mycobacterium tuberculosis and Toxoplasma gondii.
Stefan Bidula, B. Cromer, S. Walpole, J. Angulo, L. Stokes   +4 more
semanticscholar   +1 more source

Dynamic hydration valve controlled ion permeability and stability of NaK channel [PDF]

, 2008
The K^+^, Na^+^, Ca^2+^ channels are essential to neural signalling, but our current knowledge at atomic level is mainly limited to that of K^+^ channels.
Rong Shen, Wanlin Guo, Wenyu Zhong
core   +1 more source

MicroED structure of the NaK ion channel reveals a Na+ partition process into the selectivity filter. [PDF]

, 2018
Sodium (Na+) is a ubiquitous and important inorganic salt mediating many critical biological processes such as neuronal excitation, signaling, and facilitation of various transporters.
Gonen, Tamir, Liu, Shian
core   +2 more sources

Blocking the voltage‐gated sodium channel hNav1.5 as a novel pH‐dependent mechanism of action for tamoxifen

FEBS Open Bio, EarlyView.
Patch‐clamp recordings revealed that tamoxifen inhibits voltage‐gated sodium channels, especially under acidic conditions, both common in metastatic cancer cells. These effects may explain certain antitumor properties of tamoxifen, highlighting a novel mechanism of action beyond its known endocrine effects.
Karl Josef Föhr, Michael Fauler, Thomas Zimmer, Bettina Jungwirth, Hubert Schrezenmeier, David Alexander Christian Messerer   +5 more
wiley   +1 more source

The effect of noise exposure on the vestibular systems of dental technicians

Noise and Health, 2019
Background: Noise exposure is the primary cause of acquired hearing loss in several occupational settings, including dental laboratories and clinics. However, the impact of noise exposure on the vestibular system is not as well researched.
Safa Alqudah
doaj   +1 more source