Results 51 to 60 of about 23,984 (311)

DNA Nanoflower LYTACs Enable Efficient VEGF Degradation and Verteporfin Loading for Combined Therapy of Wet Age‐Related Macular Degeneration

Advanced Science, EarlyView.
An integrated approach that combines a DNA nanoflower VEGF degrader with photodynamic therapy is developed for the treatment of wet age‐related macular degeneration, which reduces the risk of VEGF reactivation‐induced CNV recurrence and minimizes the systemic side effects associated with photodynamic therapy.
Mengxuan Li, Yan Yue, Sijin Wu, Xinyu He, Jiayi Song, Shuwen Ma, Haokun Zhang, Chenyu Xu, Song Chen, Yanming Huang, Songbo Xie, Hua Yan   +11 more
wiley   +1 more source

Single-stage surgical procedure for increasing depth of vestibule and the width of attached gingiva

Journal of Oral Research and Review, 2015
Shallow vestibule along with the inadequate width of attached gingiva is a common cause of the gingival recession. Multiple techniques have been developed, separately, to increase the depth of vestibule and the width of attached gingival but this case ...
Mohammad Arif Khan, Amitandra Kumar Tripathi, Rajeev Kumar Jaishwal, Poonam Agrawal   +3 more
doaj   +1 more source

Magnetic Resonance Imaging Reveals Meningeal Lymphatic Impairment in Lung Adenocarcinoma Brain Metastasis Progression

Advanced Science, EarlyView.
This study demonstrates meningeal lymphatic impairment associated with lung adenocarcinoma brain metastasis progression in both human patients and mouse models, establishes clinically applicable non‐invasive imaging biomarkers for quantitative analyzing mLV structure and function, and reveals mLVs as robust prognostic indicators and promising potential
Yuan Zhang, Shucheng Jin, Penghui Guo, Yuying Yin, Yichun Hua, Xiaosheng Ding, Zhe Zhang, Shuo Chen, Xu Han, Baowang Li, Yan Liu, Xiaoyan Li, Deling Li, Jing Jing, Wei Shi, Wang Jia   +15 more
wiley   +1 more source

Structure‐Guided Engineering of a Promiscuous O‐Methyltransferase for a SAM Regeneration Biocatalysis Platform of Methylated Pharmaceuticals

Advanced Science, EarlyView.
A substrate promiscuous and regioselective O‐methyltransferase, SmOMT, is functionally and structurally characterized. A double mutant, SmOMTE152A/I306A, exhibited enhanced catalytic activity. By coupling this mutant with a mutant halide methyltransferase, AtHMTV140T, for SAM regeneration, a superior artificial fusion enzyme, AtHMTV140T‐L95‐SmOMTE152A ...
Xiran Xiong, Jun Song, Shihan Li, Lu Jin, Qi He, Baohui Zhang, Yan Cao, Shanyong Yi, Yanfang Yang, Xiang Li, Juan Li, Wei Huang   +11 more
wiley   +1 more source

The Outer Vestibule of the Na+ Channel–Toxin Receptor and Modulator of Permeation as Well as Gating

Marine Drugs, 2010
The outer vestibule of voltage-gated Na+ channels is formed by extracellular loops connecting the S5 and S6 segments of all four domains (“P-loops”), which fold back into the membrane. Classically, this structure has been implicated in the control of ion
René Cervenka, Touran Zarrabi, Peter Lukacs, Hannes Todt   +3 more
doaj   +1 more source

Compensatory Interplay Between Clarin‐1 and Clarin‐2 Deafness‐Associated Proteins Governs Phenotypic Variability in Hearing

Advanced Science, EarlyView.
Functional compensation between clarin‐1 and clarin‐2 in cochlear hair cells. Hearing loss associated with CLRN1 mutations shows striking phenotypic variability; however, the underlying mechanisms remain poorly understood. This study reveals that clarin‐1 and clarin‐2 function cooperatively in cochlear hair cells to sustain mechanoelectrical ...
Maureen Wentling, Aïda Yakhlef Sanchez, Nicolas Thelen, Müge Senarisoy, Maria Hogg, Steven Condamine, Andrea Lelli, Emilia Wysocka, Pranav Patni, Sandrine Vitry, Kerem Yasin Yildizhan, Sébastien Le Gal, Sylvie Nouaille, Michael R. Bowl, Marc Thiry, Didier Dulon, Sedigheh Delmaghani, Aziz El‐Amraoui   +17 more
wiley   +1 more source

Effect of vestibular symptoms on balance and walking function in patients with acute brain stem infarction

Chinese Journal of Contemporary Neurology and Neurosurgery
Objective To investigate the correlation between vestibular symptoms and balance/ walking function in patients with acute brain stem infarction. Methods Fifty-one patients with acute brain stem infarction with a Functional Ambulation Category Scale ...
HUANG Mao‐juan, CUI Li‐ling, WANG Fei, CHEN Jun‐ying, ZHANG Yue, WU Jia‐ling   +5 more
doaj   +1 more source

Impact of Extrusion and Direct Calendering on Dry‐Coated Cathodes for Sulfidic All‐Solid‐State Batteries

Advanced Energy Materials, EarlyView.
This work demonstrates a parameter optimization for a scalable dry coating process of sulfidic ASSB cathodes (82 wt% CAM, 0.5 wt% PTFE binder) in dry room atmosphere. High‐shear extruder mixing and calendering are used to form a cathode film based on PTFE fibrillation.
Michael Wolf, Benjamin vom Hau, Rebecca Wilhelm, Matti M. Kaye, Aaron Stoeckle, Johannes Kriegler, Florian Schmidt, Stefan Stojcevic, Korbinian Huber, Simon Lux   +9 more
wiley   +1 more source

Changes in Alcohol Retail Laws and Foot Traffic at Liquor Stores

Applied Economic Perspectives and Policy, EarlyView.
ABSTRACT We study how expanding alcohol availability at grocery and convenience stores affects consumer traffic in liquor stores by leveraging recent changes in state‐level alcohol distribution laws in a difference‐in‐difference quasi‐experimental design.
Nathan Palardy, Marco Costanigro, Joshua Berning, Jude Bayham   +3 more
wiley   +1 more source

Druggable site near the upper vestibule determines the high affinity and P2X3 homotrimer selectivity of sivopixant/S‐600918 and its analogue DDTPA [PDF]

, 2023
Dongping Wang, Meng Zhang, Ming Li, Xiaona Yang, Changzhu Li, Peng Cao, Michael X. Zhu, Yun Tian, Ye Yu, Yuntao Lei   +9 more
openalex   +1 more source