Results 51 to 60 of about 70,503 (403)

Precision medicine: a new era for inner ear diseases

open access: yesFrontiers in Pharmacology
The inner ear is the organ responsible for hearing and balance. Inner ear dysfunction can be the result of infection, trauma, ototoxic drugs, genetic mutation or predisposition. Often, like for Ménière disease, the cause is unknown.
Elisa Tavazzani   +8 more
doaj   +1 more source

Cotranslational folding of proteins on the ribosome.

open access: yes, 2020
Many proteins in the cell fold cotranslationally within the restricted space of the polypeptide exit tunnel or at the surface of the ribosome. A growing body of evidence suggests that the ribosome can alter the folding trajectory in many different ways ...
Liutkute, M., Rodnina, M., Samatova, E.
core   +1 more source

MicroED structure of the NaK ion channel reveals a Na+ partition process into the selectivity filter. [PDF]

open access: yes, 2018
Sodium (Na+) is a ubiquitous and important inorganic salt mediating many critical biological processes such as neuronal excitation, signaling, and facilitation of various transporters.
Gonen, Tamir, Liu, Shian
core   +2 more sources

Mapping a novel positive allosteric modulator binding site in the central vestibule region of human P2X7

open access: yesScientific Reports, 2019
P2X7 receptors are important in the regulation of inflammatory responses and immune responses to intracellular pathogens such as Mycobacterium tuberculosis and Toxoplasma gondii.
Stefan Bidula   +4 more
semanticscholar   +1 more source

The effect of noise exposure on the vestibular systems of dental technicians

open access: yesNoise and Health, 2019
Background: Noise exposure is the primary cause of acquired hearing loss in several occupational settings, including dental laboratories and clinics. However, the impact of noise exposure on the vestibular system is not as well researched.
Safa Alqudah
doaj   +1 more source

Clean Cut (adaptive, multimodal surgical infection prevention programme) for low‐resource settings: a prospective quality improvement study

open access: yesBJS (British Journal of Surgery), EarlyView., 2020
Clean Cut is a multimodal, adaptive, checklist‐based infection prevention programme designed to improve compliance with six critical perioperative infection prevention practices. After introducing the programme at five hospitals in Ethiopia, compliance with critical infection prevention standards significantly improved and the relative risk of ...
J. A. Forrester   +16 more
wiley   +1 more source

microRNAs: the art of silencing in the ear

open access: yesEMBO Molecular Medicine, 2012
MicroRNAs (miRNAs) are small non‐coding RNAs that regulate gene expression through the RNA interference (RNAi) pathway and by inhibition of mRNA translation.
Anya Rudnicki, Karen B. Avraham
doaj   +1 more source

Dynamic hydration valve controlled ion permeability and stability of NaK channel [PDF]

open access: yes, 2008
The K^+^, Na^+^, Ca^2+^ channels are essential to neural signalling, but our current knowledge at atomic level is mainly limited to that of K^+^ channels.
Rong Shen, Wanlin Guo, Wenyu Zhong
core   +1 more source

Radon mitigation during the installation of the CUORE $0\nu\beta\beta$ decay detector

open access: yes, 2018
CUORE - the Cryogenic Underground Observatory for Rare Events - is an experiment searching for the neutrinoless double-beta ($0\nu\beta\beta$) decay of $^{130}$Te with an array of 988 TeO$_2$ crystals operated as bolometers at $\sim$10 mK in a large ...
Benato, G.   +11 more
core   +1 more source

Identifying High‐Impact Solutions to Address Racial and Ethnic Health Disparities in Lupus: A Consensus‐Based Approach

open access: yesArthritis Care &Research, Accepted Article.
Objective We conducted formative research aimed at identifying solutions that address inequitable health outcomes in lupus due to adverse social determinants of health. Methods We conducted a search for keywords which provided insights into potential solutions and initiatives underway. An advisory panel of lupus experts iteratively reviewed the list of
Joy Buie   +11 more
wiley   +1 more source

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