Results 61 to 70 of about 22,199 (323)
The Outer Vestibule of the Na+ Channel–Toxin Receptor and Modulator of Permeation as Well as Gating
Marine Drugs, 2010 The outer vestibule of voltage-gated Na+ channels is formed by extracellular loops connecting the S5 and S6 segments of all four domains (“P-loops”), which fold back into the membrane. Classically, this structure has been implicated in the control of ion
René Cervenka +3 more
doaj +1 more source
Motion Control on Bionic Eyes: A Comprehensive Review [PDF]
arXiv, 2019 Biology can provide biomimetic components and new control principles for robotics. Developing a robot system equipped with bionic eyes is a difficult but exciting task. Researchers have been studying the control mechanisms of bionic eyes for many years and considerable models are available.
arxiv
Advanced Science, EarlyView.By investigating auditory hyperexcitability in a mouse model for hereditary deafness, this study identified a subpopulation of afferent neurons of the auditory nerve marked by Otogl expression. Despite their apparently normal hearing, Otogl+/− mice display poor activation of afferent neurons processing loud sounds and an elevation of the middle the ear
Mathilde Gagliardini +24 more
wiley +1 more source
On computational fluid dynamics models for sinonasal drug transport: relevance of nozzle subtraction and nasal vestibular dilation [PDF]
arXiv, 2017 Generating anatomically realistic three-dimensional (3D) models of the human sinonasal cavity for numerical investigations of sprayed drug transport presents a host of methodological ambiguities. For example, subject-specific radiographic images used for 3D reconstructions typically exclude spray bottles.
arxiv
NF2 is Essential for Human Endoderm Development
Advanced Science, EarlyView.This study demonstrates that NF2, moesin‐ezrin‐radixin like (MERLIN) tumor suppressor (NF2) is essential for human endoderm formation. NF2 knockout human induced pluripotent stem cells fail to form endoderm both in vitro and in vivo due to yes‐associated protein 1 (YAP1) nuclear translocation, redirecting differentiation toward myofibroblast‐like cells.
Minjin Jeong +5 more
wiley +1 more source
Histone Deacetylase 6 (HDAC6) in Ciliopathies: Emerging Insights and Therapeutic Implications
Advanced Science, EarlyView.HDAC6 regulates primary cilia, crucial for cellular signalling and environmental responses. Dysregulation of HDAC6 contributes to ciliopathies, affecting multiple organs. This review examines HDAC6's role in ciliogenesis, its interaction with signaling molecules, and its potential as a therapeutic target.
Zhiyi Wang +5 more
wiley +1 more source
Advanced Science, EarlyView.S‐ketamine binds directly to SIRT2, facilitating its interaction with NF‐κB p65. This interaction reduces the acetylation of NF‐κB p65 and inhibits its activation, thereby exerting anti‐inflammatory and antidepressant effects. Created by BioRender.
Cong Lin +7 more
wiley +1 more source
eLife, 2020 Pentameric ligand-gated ion channels (pLGICs) or Cys-loop receptors are involved in fast synaptic signaling in the nervous system. Allosteric modulators bind to sites that are remote from the neurotransmitter binding site, but modify coupling of ligand ...
Marijke Brams +12 more
doaj +1 more source
The effect of geographical denomination on the uptake of fungus‐resistant grapes
Applied Economic Perspectives and Policy, EarlyView.Abstract Grape production for wine making is of great economic and cultural importance in Europe, but is heavily dependent on pesticides. Reducing pesticide use and associated risks is a policy goal in several countries, particularly in Europe. The most effective strategy to substantially reduce pesticide use in grape production is the planting of ...
Lucca Zachmann +2 more
wiley +1 more source
Clinical and Experimental Dental Research, Volume 8, Issue 6, Page 1440-1448, December 2022., 2022 Abstract Objectives To test the hypothesis that routine dental radiographs can be used to draw conclusions regarding the mandibular canal (MC) localization. Material and Methods A total of 108 radiographs (36 orthopantomograms [OPTs], 36 lateral cephalograms [LCs], and 36 cone‐beam computed tomograms [CBCTs]) of 36 patients were analyzed.
Bernhard Wiechens +5 more
wiley +1 more source