Results 161 to 170 of about 4,250,967 (338)

Chronic high‐fat diet induces multi‐organ dysfunction and metabolic homeostasis disruption in Macaca fascicularis

open access: yesAnimal Models and Experimental Medicine, EarlyView.
An 18‐month HFD successfully established a translational Macaca fascicularis model replicating key metabolic disorders (MASH, diabetes, cardiac hypertrophy). MASH was determined by liver biopsy histology, the presence steatosis, inflammatory infiltration, hepatocytic ballooning, and fibrosis were considered as MASH; diabetes was diagnosed according to ...
Hongyi Chen   +12 more
wiley   +1 more source

Establishment of a novel cynomolgus monkey model of hyperuricemia

open access: yesAnimal Models and Experimental Medicine, EarlyView.
We established a novel hyperuricemia model in cynomolgus monkeys (A) via oral administration of potassium oxonate, hydrochlorothiazide, and adenine mixed in fruits and vegetables. This model (B) targets uric acid synthesis and enzymatic degradation, and (C) regulates renal and intestinal excretion, thereby stably elevating serum uric acid and serving ...
Ji‐Wei Wang   +12 more
wiley   +1 more source

Metal‒organic frameworks for on-demand drug release and precision drug delivery

open access: yesOne Health Advances
Metal‒organic frameworks (MOFs) are porous materials that combine high stability, large surface areas, excellent porosity, and low toxicity. The rapid development of these drugs has opened new opportunities to enhance drug efficacy with reduced adverse ...
Danlei Hu   +6 more
doaj   +1 more source

Human Brain Contusions Contain Pathogenic Transmissible Species that Induce Progressive Cognitive Decline and Tau Pathology in Mice

open access: yesAnnals of Neurology, EarlyView.
Objective Traumatic brain injury (TBI) is an established risk factor for dementia, although the underlying mechanisms remain unclear. Our previous research demonstrated that a single severe TBI in wild‐type (WT) mice induces a prion‐like form of tau (tauTBI) that spreads throughout the brain, leading to memory deficits.
Gloria Vegliante   +19 more
wiley   +1 more source

Decoding the Pathophysiology of Autoimmune Diseases—Mechanism, Triggers, and Nanotherapeutics: A Review

open access: yesAdvanced NanoBiomed Research, EarlyView.
This review highlights how autoimmune diseases arise from intertwined immunological, genetic, and environmental factors, emphasizing gut microbiota dysbiosis as a pivotal driver. It outlines emerging nanotechnology‐based strategies—such as liposomes, hydrogels, and polymeric nanoparticles—that enhance targeted drug delivery, minimize systemic toxicity,
Md. Meraj Ansari   +5 more
wiley   +1 more source

Eggshell‐Based Biochar for Superior Adsorption of Crystal Violet Dye and Fluoride From Wastewater

open access: yesAsia-Pacific Journal of Chemical Engineering, EarlyView.
ABSTRACT Present study investigates the efficiency of eggshell biochar as a low‐cost and ecofriendly adsorbent for the simultaneous removal of fluoride ions and crystal violet (CV) dye from wastewater. The eggshell waste was pyrolyzed to produce biochar, which was thoroughly characterized and subsequently employed for contaminant adsorption.
T. Mounika   +3 more
wiley   +1 more source

Polylimonene Improves the In Vivo Wound Healing Performance of Sodium Alginate‐Based Hydrogels

open access: yesJournal of Applied Polymer Science, EarlyView.
An oligomer derived from orange peel essential oil incorporated into an alginate hydrogel was shown to be biocompatible and to exhibit a high capacity for in vivo incisional wound healing, as confirmed by experimental assays and mathematical models fitted to the data describing wound area reduction as a function of the dressing‐tissue contact time ...
Roniérik Pioli Vieira   +5 more
wiley   +1 more source

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