Results 271 to 280 of about 244,268 (306)

Metabolic abnormalities and reprogramming in cats with naturally occurring hypertrophic cardiomyopathy

ESC Heart Failure, Volume 12, Issue 2, Page 1256-1270, April 2025.
Abstract Background and aims The heart is a metabolic organ rich in mitochondria. The failing heart reprograms to utilize different energy substrates, which increase its oxygen consumption. These adaptive changes contribute to increased oxidative stress.
Qinghong Li, Max Homilius, Erin Achilles, Laura K. Massey, Victoria Convey, Åsa Ohlsson, Ingrid Ljungvall, Jens Häggström, Brittany Vester Boler, Pascal Steiner, Sharlene Day, Calum A. MacRae, Mark A. Oyama   +12 more
wiley   +1 more source

Severity of effect considerations regarding the use of mutation as a toxicological endpoint for risk assessment: A report from the 8th International Workshop on Genotoxicity Testing (IWGT)

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Exposure levels without appreciable human health risk may be determined by dividing a point of departure on a dose–response curve (e.g., benchmark dose) by a composite adjustment factor (AF). An “effect severity” AF (ESAF) is employed in some regulatory contexts.
Barbara L. Parsons, Marc A. Beal, Kerry L. Dearfield, George R. Douglas, Min Gi, B. Bhaskar Gollapudi, Robert H. Heflich, Katsuyoshi Horibata, Michelle Kenyon, Alexandra S. Long, David P. Lovell, Anthony M. Lynch, Meagan B. Myers, Stefan Pfuhler, Alisa Vespa, Andreas Zeller, George E. Johnson, Paul A. White   +17 more
wiley   +1 more source

Comparative assessment of artificial intelligence chatbots' performance in responding to healthcare professionals' and caregivers' questions about Dravet syndrome

Epilepsia Open, EarlyView.
Abstract Objective Artificial intelligence chatbots have been a game changer in healthcare, providing immediate, round‐the‐clock assistance. However, their accuracy across specific medical domains remains under‐evaluated. Dravet syndrome remains one of the most challenging epileptic encephalopathies, with new data continuously emerging in the ...
Joana Jesus‐Ribeiro, Eugenia Roza, Bárbara Oliveiros, Joana Barbosa Melo, Mar Carreño   +4 more
wiley   +1 more source

Experimental infection of horses with African horse sickness virus results in overt disseminated intravascular coagulation

Equine Veterinary Journal, EarlyView.
Abstract Background African horse sickness (AHS), caused by the vector‐borne African horse sickness virus (AHSV), is endemic to sub‐Saharan Africa and infection results in high mortality in naïve equine populations. Clinical signs include submucosal petechiae and prolonged bleeding post venepuncture indicative of hypocoagulation.
Eva Christina Schliewert, Amelia Goddard, Emma H. Hooijberg   +2 more
wiley   +1 more source

Quality analysis of albendazole formulations available in veterinary pharmacies of Nepal. [PDF]

BMC Pharmacol Toxicol
Dhakal SP, Acharya B, Rana S, Sedhai S, Manandhar S.   +4 more
europepmc   +1 more source

Characterization of in vitro intestinal absorption of veterinary drugs and coccidiostats in the presence of mycotoxin detoxifiers using a porcine intestinal epithelial cell line: outline of the study

, 2013
Thomas De Mil, Mathias Devreese, Ann Osselaere, Elin Verbrugghe, Joline Goossens, Frank Pasmans, Patrick De Backer, Siska Croubels   +7 more
openalex   +1 more source

Beyond the Food We Eat: Animal Drugs in Livestock Production [PDF]

, 2015
Schneider, Susan A.
core   +1 more source

Equine trypanosomiasis, a systematic review: Disease management

Equine Veterinary Journal, EarlyView.
Abstract Background Equine trypanosomiasis is a neglected protozoal disease. Objectives To answer the study question: In equines what are the effects of disease management of trypanosomiasis on disease severity (individual level) and disease prevalence (population level) compared to no intervention? Study Design Systematic review.
Alexandra G. Raftery, Lauren Gummery, Karelhia Garcia, Dinesh Mohite, Paul Capewell, David Sutton   +5 more
wiley   +1 more source

Drug Repurposing in Veterinary Oncology: Myth or Reality? [PDF]

Vet Sci
Ciccarelli S, Perrone C, Cavalera MA, Giuliano A.   +3 more
europepmc   +1 more source

Effect of surgical antimicrobial prophylaxis duration for colic surgery on complications and resistome

Equine Veterinary Journal, EarlyView.
Abstract Background Based on human studies, surgical antimicrobial (AMD) prophylaxis (SAP) beyond 24 h is unnecessary and potentially detrimental. Objective To compare clinical and microbiological outcomes in patients receiving 24‐ or 72‐h of SAP for colic surgery. Study Design Prospective randomised clinical trial.
Louise L. Southwood, Alicia Long, Jairo Perez, Scott Daniel, Kyle Bittinger, Maia Aitken, Laurel Redding   +6 more
wiley   +1 more source