Results 31 to 40 of about 103,029 (263)

Gardiquimod Nanoemulsion Targets Cutaneous Leishmaniasis Lesions Reducing Systemic Toxicity and Parasite Burden

Advanced Healthcare Materials, EarlyView.
Nanoemulsion delivery of a TLR7 agonist enhances safety and promotes colocalization with Leishmania‐infected macrophages in skin lesions, enabling a ∼2‐log reduction in parasite burden. However, tissue‐level constraints and TLR‐driven regulatory feedback generate a mixed immune response that limits complete parasite clearance.
Carmen Palomino‐Cano, M. Carmen Mera‐Delgado, Esther Moreno, Esther Larrea, Lecnia Aguirre, Jonathan Miguel Zanatta, Sónia Barros‐Carvalho, Iola F. Duarte, Ricardo Silvestre, Juan M. Irache, Javier Carrión, Socorro Espuelas   +11 more
wiley   +1 more source

Comparative Evaluation of Modified Vaccinia Ankara as a Surrogate Virus for Disinfectant Efficacy Testing Against AIV, FMDV, and ASFV

Viruses
Surrogate viruses provide a safe and scalable alternative for evaluating disinfectant efficacy when access to high-risk pathogens is restricted. This study evaluated the potential of Modified Vaccinia Ankara (MVA) virus, which can be handled under BSL-1 ...
Sok Song, Su-Jeong Kim, Kyu-Sik Shin, So-Hee Park, Yong Yi Joo, Bokhee Han, Cho-Yeon Lee, Gong-Woo Park, Hyun-Ok Ku, Wooseog Jeong, Choi-Kyu Park   +10 more
doaj   +1 more source

Characteristics of the plasmid-mediated colistin-resistance gene mcr-1 in Escherichia coli isolated from a veterinary hospital in Shanghai

Frontiers in Microbiology, 2022
The mobile colistin-resistance (mcr)-1 gene is primarily detected in Enterobacteriaceae species, such as Escherichia coli and Salmonella enterica, and represents a significant public health threat.
Hongguang Lin, Hongguang Lin, Wenxin Chen, Wenxin Chen, Rushun Zhou, Jie Yang, Jie Yang, Yong Wu, Yong Wu, Jiaomei Zheng, Shuyue Fei, Shuyue Fei, Guiting Wu, Guiting Wu, Zhiliang Sun, Zhiliang Sun, Jiyun Li, Jiyun Li, Xiaojun Chen, Xiaojun Chen   +19 more
doaj   +1 more source

Negotiating in a Foreign Land: Understanding the Curious Interactions Between Intracellular Mitochondria and Internalized Nanoparticles

Advanced Materials Interfaces, EarlyView.
Therapeutic nano‐drug delivery systems interact with cellular mitochondria in a multitude of ways. While the complexity of such interactions disrupts the mitochondrial electron transport chain and increases reactive oxygen species production, thereby contributing to nanoparticle toxicity, they also present unique theranostic opportunities in diseases ...
Sourav Bhattacharjee
wiley   +1 more source

High-quality genome assembly and annotation of live animal vaccine bacteria strains in South Korea

BMC Genomic Data
Objectives Selecting and managing suitable seed strains according to standard principles is a critical factor in manufacturing high-quality biological products.
Yeonkyeong Lee, Jin-Ju Nah, Hyun-Ok Ku, Il Jang   +3 more
doaj   +1 more source

Proteomic analysis of the second-generation merozoites of Eimeria tenella under nitromezuril and ethanamizuril stress

Parasites & Vectors, 2019
Background Eimeria tenella is a highly pathogenic coccidian that causes avian coccidiosis. Both nitromezuril (NZL) and ethanamizuril (EZL) are novel triazine compounds with high anticoccidial activity, but the mechanisms of their action are still unclear.
Xue-Yan Li, Li-Li Liu, Min Zhang, Li-Fang Zhang, Xiao-Yang Wang, Mi Wang, Ke-Yu Zhang, Ying-Chun Liu, Chun-Mei Wang, Fei-Qun Xue, Chen-Zhong Fei   +10 more
doaj   +1 more source

Supply Chain and Delivery of Antimicrobial Drugs in Smallholder Livestock Production Systems in Uganda

Frontiers in Veterinary Science, 2021
This study assessed the veterinary drug supply chain in Uganda, the constraints faced by the actors, and how the challenges influence the use of antimicrobial (AMs) by livestock farmers.
Michel Mainack Dione, Winfred Christine Amia, Francis Ejobi, Emily Awuor Ouma, Barbara Wieland, Barbara Wieland   +5 more
doaj   +1 more source

Tropomyosin 1 Promotes Platelet Adhesion and Clot Contraction Separate from Its Roles in Developmental Hematopoiesis

Advanced Science, EarlyView.
ABSTRACT Genome‐wide association studies (GWAS) link the Tropomyosin 1 (Tpm1) locus to quantitative blood trait variation, but related mechanisms are unclear. Tpm1 encodes an actin‐binding protein that regulates actin filament diversity, cell adhesion, signaling, and actomyosin contractility.
Po‐Lun Kung, Victor Tsao, Alina D Peshkova, Oscar A. Marcos‐Contreras, Kim Ha, Brian M Dulmovits, Nkemdilim Okoli, Anvi Sinha, Gennadiy Fonar, Rong Qiu, Rolf D Bates, Janelle Yeboah, Carson Shalaby, Tyler Truex, Soomin Jeong, Edna C Hardeman, Peter W Gunning, Vladimir R Muzykantov, Jacob W Myerson, Christopher S Thom   +19 more
wiley   +1 more source

Metagenomic analysis of gut microbiota diversity in poultry before and after antibiotic administration

Ветеринария сегодня
The diversity of gut microbiota is an important ecological resource that plays a key role in maintenance of the host homeostasis. It is extremely important to preserve the existing gut microbiota diversity, which ensures its resistance to the negative ...
O. V. Prasolova, N. I. Malik, I. A. Timofeeva, N. A. Kirsanova, E. V. Krylova, E. V. Malik, I. A. Rusanov, N. A. Chupakhina   +7 more
doaj   +1 more source

A Toolkit for Targeted Neuromodulation of Striatal Direct Pathway Neurons Rescues Parkinsonian Motor Deficits in Mice

Advanced Science, EarlyView.
An adeno‐associated virus (AAV) toolkit enables selective anatomical and functional targeting of striatal D1‐MSNs through retrograde transduction. Enhanced capsids and engineered enhancers drive robust transgene expression across murine and primate models.
Zexuan Hong, Yujing Zhang, Junjiao Zhang, Hanhe Liu, Qiwei Liu, Yanglei Li, Lixin Yang, Lixia Li, Zhongjie Liu, Zhen Yuan, Zhonghua Lu, Yefei Chen, Yuantao Li, Yuwu Jiang, Taian Liu   +14 more
wiley   +1 more source