Results 71 to 80 of about 242,836 (309)

Natural Products Inspired Scaffold Diversification Leads to Unnatural Molecular Warhead and Covalent Strategy to Modulating Protein Function through Electrophilic Bromine Transfer

Advanced Science, EarlyView.
We report a new thiolate‐reactive α,α‐gem‐dibromo lactam warhead that activates transcription factor Nrf2 and demonstrates anti‐inflammatory activities, which have implications in cancer, neurodegeneration, and cardiovascular diseases. RNA‐seq illuminated detailed transcriptional profiles, and chemical reactions with cysteine‐containing compounds ...
Beau R. Brummel, Sofia Kokkaliari, Qiwen Gao, Jinjing Chen, Larissa Costa de Almeida, Srinivasarao Tenneti, Derek A. Leas, Eli Levit, Lewis S. Alexander, Khalil A. Abboud, Pingrong Wei, Michael D. Cameron, James R. Rocca, Ranjala Ratnayake, Donna D. Zhang, Hendrik Luesch, Robert W. Huigens III   +16 more
wiley   +1 more source

Toxicity testing of the veterinary use drugs [PDF]

Medicamentul Veterinar, 2007
Before the authorization for comercialization both medical and phyto-sanitary products must be tested for inocuity and toxicity, the risk assesment for persons working in drug industry, pharmacy, human beings and animals treated with the product and for ...
Solcan Gh.,, Beschea Chiriac I. S.,
doaj  

Risk-based approach to develop a national residue program: prioritizing the residue control of veterinary drugs in fishery products

Fisheries and Aquatic Sciences, 2019
Veterinary drugs are widely used to protect production-related diseases and promote the growth of farmed fish. The use of large amounts of veterinary drugs may have potential risk and cause adverse effects on both humans and the environment.
Hui-Seung Kang, Songyi Han, Byung-Hoon Cho, Hunjoo Lee   +3 more
doaj   +1 more source

Improved Systemic Immunochemotherapy Employing an Oxaliplatin‐TLR7/8 Agonist Prodrug Strategy

Advanced Science, EarlyView.
A platinum(IV) prodrug is developed to systemically deliver the TLR7/8 agonist gardiquimod. Tumor‐targeting is mediated by an albumin‐binding maleimide, which limits premature complex activation. Ox‐Gardi‐Mal accumulates specifically in the tumor, where it activates the immune system.
Michael Gutmann, Martijn Dijkstra, Philipp Salomon, Jamie Cowles, Anja Federa, Dina Baier, Carola Jaunecker, Iemima Semerean, Venla Karvonen, Christine Pirker, Maria Sibilia, Dietmar Herndler‐Brandstetter, Petra Heffeter, Bernhard K. Keppler, Christian R. Kowol, Walter Berger   +15 more
wiley   +1 more source

A Practical Framework for ASFV Disinfectant Evaluation: Differentiating Cytopathic Effects from Cytotoxicity via Integrated Analytical Methods

Pathogens
African swine fever virus (ASFV) is a highly virulent DNA virus that has spread globally since its introduction into Georgia in 2007, causing substantial economic losses in the swine industry. In the absence of an effective vaccine, chemical disinfection
Sok Song, Kyu-Sik Shin, Su-Jeong Kim, Yong Yi Joo, Bokhee Han, So-Hee Park, Hyun-Ok Ku, Wooseog Jeong, Choi-Kyu Park   +8 more
doaj   +1 more source

Authorisation procedures for veterinary medicinal produscts and application types [PDF]

Medicamentul Veterinar, 2009
The authorization process of veterinary medicinal products is an complex and laborious process, which is accomplished through multiple stages and by centralized procedures, communitary or nationals in the respect of 2001/82/EC Directive amended by the ...
Alina Karina Draghici,, Lollita Taban
doaj  

Cytokine response to the RSV antigen delivered by dendritic cell-directed vaccination in congenic chicken lines

Veterinary Research, 2017
Systems of antigen delivery into antigen-presenting cells represent an important novel strategy in chicken vaccine development. In this study, we verified the ability of Rous sarcoma virus (RSV) antigens fused with streptavidin to be targeted by specific
Jitka Mucksová, Jiří Plachý, Ondřej Staněk, Jiří Hejnar, Jiří Kalina, Barbora Benešová, Pavel Trefil   +6 more
doaj   +1 more source

Animal poisonings in Belgium: a review of the past decade [PDF]

, 2010
This review focuses on poisonings in companion animals, including horses, farm animals and wildlife, investigated and recorded during the past ten years at the Laboratory of Toxicology of the Faculty of Veterinary Medicine (Ghent University) and the ...
Croubels, Siska, De Backer, Patrick, Van Pelt, Henk, Vandenbroucke, Virginie   +3 more
core   +1 more source

Maternal Preconception Antibiotic Exposure Disrupts Microbial Succession: A Transgenerational Risk for Offspring Gut Mucosal Immaturity and Colitis Susceptibility

Advanced Science, EarlyView.
This study reveals that maternal antibiotic exposure prior to conception disrupts intergenerational gut microbial succession. By enhancing maternal‐offspring microbial transmission, altering microbial developmental trajectories and increasing selective pressures during community assembly, these disturbances lead to persistent gut mucosal immaturity and
Yuzhu Chen, Ruqiao Duan, Cunzheng Zhang, Gaonan Li, XiaoLin Ji, Qi Zhang, Fei Pei, Kun Wang, Liping Duan   +8 more
wiley   +1 more source

Rapid sexing of selected Galliformes by polymerase chain reaction

Czech Journal of Animal Science, 2012
Vent sexing of one-day-old chicks in commercial hatcheries has long been common practice and can be highly accurate. However, there are circumstances when this technique is not applicable such as smaller breeds, non-domestic birds, or where is the ...
J. Kalina, J. Mucksová, H. Yan, P. Trefil   +3 more
doaj   +1 more source