Results 101 to 110 of about 27,865,843 (231)

Closing the Empirical Loop: Autonomous AI Agents Conduct End‐to‐end Research With Human Participants

Advanced Science, EarlyView.
A multi‐agent AI system autonomously executes the complete scientific workflow, from hypothesis to manuscript, across three psychological studies involving 288 participants. The system designs experiments, collects real world data, develops analysis pipelines, and writes manuscripts with theoretical rigor comparable to experienced researchers.
Gabrielle Wehr, Reuben Rideaux, Amaya J. Fox, David R. Lightfoot, Jason Tangen, Jason B. Mattingley, Shane E. Ehrhardt   +6 more
wiley   +1 more source

A review on the evolution of methods for intestinal in vitro organ culture and its application in veterinary science. [PDF]

Vet World, 2023
Cortez BRS, Guedes RMC.
europepmc   +1 more source

Pyrazole‐Derived Antibacterial Compounds Effectively Treat Methicillin‐Resistant Staphylococcus Aureus Infections by Inhibiting Aspartate Transcarbamoylase

Advanced Science, EarlyView.
This study unveils a novel antibacterial mechanism against MRSA, in which the compound Py‐27 selectively targets and inhibits aspartate transcarbamoylase (ATCase), a key enzyme in pyrimidine synthesis. This inhibition disrupts DNA replication, induces oxidative damage, leading to potent bactericidal activity.
Xiaorong Yang, Xinyuan Cao, Lixia Dai, Feng Yang, Jing Wang, Yudong Ma, Tong Bu, Zile Gong, Xueyan Liu, Changcai Bai, Xiaolou Miao, Xiaofei Shang   +11 more
wiley   +1 more source

Community Engagement newsletter, Faculty of Veterinary Science, Winter, 2012 [PDF]

, 2012
News articles with colour photos about the various community engagement projects of the Faculty of Veterinary Science, University of Pretoria.Mangaung community receives support from Onderstepoort / Willem Engelbrecht, Helzna Krikke, Ingrid Metz, Janine
Harmse, Ruche, Naude, Megan, Ntsibande, Patrick, Stemmet, Gideon, Grobler, Louw, Strydom, Nadia, Krikke, Helzna, Visser, Ansu, Greyling, Marelize, Rabe, Kobus, Light, Taryn, Van Coetzen, Este, Makae, Thapelo, Lombard, Janine, Ndashe, Noluthando, Metz, Ingrid, Lukhele, Khulekani, Bester, Daleen, De Ridder, Rhynard, Engelbrecht, Willem, Janson, Willem, Manganyi, Nyeleti, Magagula, Sabelo, Gibson, Ian, Tjasink, Tess   +24 more
core   +1 more source

Research Alliance for Veterinary Science and Biodefense BSL-3 Network (RAV3N): Report on network origin and phase I activities. [PDF]

Antiviral Res, 2023
Hunt CL, Landers RSM, Spengler JR, Motroni R, Clavijo A, Zuelke K.   +5 more
europepmc   +1 more source

In Situ Profiling of Nanoscale Strains Uncovers Mechano‐Architectural Predictors of Aging and Osteoarthritis Emergence

Advanced Science, EarlyView.
In situ mechanical loading of osteoarthritis‐prone murine knee joints reveals that spatial alterations in subchondral plate microarchitecture precede cartilage loss and promote a shift from coordinated epiphyseal strain dissipation in healthy joints to focal subchondral strain concentration in osteoarthritis‐prone joints.
Aikta Sharma, Lucinda A. E. Evans, Lucie E. Bourne, Jishizhan Chen, Alissa L. Parmenter, Joseph Brunet, Kamel Madi, Sebastian Marussi, Andrew A. Pitsillides, Peter D. Lee, Katherine A. Staines   +10 more
wiley   +1 more source

Immediate Growth Control in Response to Boiling Histotripsy is Prognostic for Intratumoral Immune Activation

Advanced Science, EarlyView.
Boiling Histrotripsy (BH), a mechanical form of focused ultrasound (FUS), allows for non‐invasive and non‐ionizing tissue destruction. Utilizing a BH treatment protocol that yielded bifurcating primary tumor growth responses, we found that immediate BH‐induced tumor growth control identifies tumors with acute reductions in antigen‐presenting cells (APC)
Lydia E. Kitelinger, Matthew R. DeWitt, Carly M. Van Wagoner, Claire A. Conarroe, Charles C. Funk, Aaron B. Streit, AeRyon Kim, Richard J. Price, Timothy N. J. Bullock   +8 more
wiley   +1 more source

Integrated Single‐Cell and TCR Profiling Reveals Protection‐Associated CD8+ T Cell Subsets Linked to Viral Control in PRRSV

Advanced Science, EarlyView.
PRRSV vaccine‐mediated protection is associated with clonally expanded cytotoxic CD8+ T cell subsets driven by viral structural proteins and supported by innate TLR4/TLR8 signaling and CD4+ T cell help, whereas non‐protective responses are characterized by dysfunctional exhausted‐like CD8+ T cells linked to poor viral control.
Can Kong, Siang Chen, Maolin Li, Meng Wang, Hailin Zhang, Bolun Zhou, Zhenhua Xie, Chen Wang, Peng Gao, Jianjun Luo, Hanchun Yang, Runsheng Chen, Dongdong Zhang, Jie Li, Jun Han   +14 more
wiley   +1 more source

Community Engagement newsletter, Faculty of Veterinary Science, Autumn, 2013 [PDF]

, 2013
News articles with colour photos about the various community engagement projects of the Faculty of Veterinary Science, University of Pretoria.The pig amble / Candice Ehlers -- Adventures with Elephants / Kivara Luke, Brad Lees, Amanda Waibel, Rowan ...
Moll, Robyn, Luke, Kivara, Lees, Brad, Leeming, Rowan, De Villiers, Stephnie, Hendry, Ross, Ehlers, Candice, Waibel, Amanda, Du Plessis, Margurite   +8 more
core   +1 more source