VgrG and PAAR Proteins Define Distinct Versions of a Functional Type VI Secretion System. [PDF]
PLoS Pathogens, 2016 The Type VI secretion system (T6SS) is widespread among bacterial pathogens and acts as an effective weapon against competitor bacteria and eukaryotic hosts by delivering toxic effector proteins directly into target cells.
Francesca R Cianfanelli +5 more
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The role of the type VI secretion system vgrG gene in the virulence and antimicrobial resistance of Acinetobacter baumannii ATCC 19606. [PDF]
PLoS ONE, 2018 The Type VI Secretion System (T6SS) is an important virulence system that exists in many bacterial pathogens, and has emerged as a potent mediator of pathogenicity in Acinetobacter baumannii. In this study, we inactivated one of the T6SS components vgrG (
Jianfeng Wang +6 more
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DotU and VgrG, core components of type VI secretion systems, are essential for Francisella LVS pathogenicity. [PDF]
PLoS ONE, 2012 The Gram-negative bacterium Francisella tularensis causes tularemia, a disease which requires bacterial escape from phagosomes of infected macrophages.
Jeanette E Bröms +4 more
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Comparative genomics of the type VI secretion systems of
BMC Genomics, 2011 Background The Type VI secretion apparatus is assembled by a conserved set of proteins encoded within a distinct locus. The putative effector proteins Hcp and VgrG are also encoded within these loci. We have identified numerous distinct Type VI secretion
De Maayer Pieter +5 more
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The SPI-20 and SPI-21 T6SS gene clusters from Salmonella enterica subspecies arizonae encode effector proteins that display antibacterial activity [PDF]
Frontiers in MicrobiologyThe type VI secretion system (T6SS) is a contact-dependent multiprotein apparatus that contributes to interbacterial competition and pathogenesis in many Gram-negative bacteria.
Ayleen Parra-Calisto +13 more
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The secretion of Pseudomonas unconventional peroxidase facilitates extracellular carbon acquisition from heterogeneous lignin [PDF]
Communications BiologyThe secretion of ligninolytic enzyme provides a competitive advantage for microbial survival. These enzymes are commonly transported to the extracellular milieu via signal peptides for the catabolism of lignin, which cannot be translocated through the ...
Congying Liang +3 more
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Genome-Wide In Silico Analysis of the Type VI Secretion System (T6SS) Within the Morganella Genus. [PDF]
Microbiologyopen▪ Species‐specific T6SS patterns among Morganella genus (M. morganii and M. sibonii). ▪ Only one‐third of M. morganii isolates haboured a T6SS. ▪ All M. sibonii possess four T6SS clusters. ▪ M. sibonii exhibited a wide diversity of effectors compared to M. morganii.
Duque M +4 more
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Structure and assembly of type VI secretion system cargo delivery vehicle
Cell Reports, 2023 Summary: Type VI secretion system is widely used in Gram-negative bacteria for injecting toxic effectors into neighboring prokaryotic or eukaryotic cells.
Wenbo He +16 more
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Genetic analysis of anti-amoebae and anti-bacterial activities of the type VI secretion system in Vibrio cholerae. [PDF]
PLoS ONE, 2011 A type VI secretion system (T6SS) was recently shown to be required for full virulence of Vibrio cholerae O37 serogroup strain V52. In this study, we systematically mutagenized each individual gene in T6SS locus and characterized their functions based on
Jun Zheng, Brian Ho, John J Mekalanos
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VgrG-dependent effectors and chaperones modulate the assembly of the type VI secretion system.
PLoS Pathogens, 2021 The type VI secretion system (T6SS) is a spear-like nanomachine found in gram-negative pathogens for delivery of toxic effectors to neighboring bacterial and host cells.
Xiaoye Liang +9 more
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