Results 1 to 10 of about 31,788 (164)
Tumor Heterogeneity in VHL Drives Metastasis in Clear Cell Renal Cell Carcinoma
Signal Transduction and Targeted Therapy, 2023 Loss of function of the von Hippel-Lindau (VHL) tumor suppressor gene is a hallmark of clear cell renal cell carcinoma (ccRCC). The importance of heterogeneity in the loss of this tumor suppressor has been under reported.
Junhui Hu, Hua Xu
exaly +2 more sources
Journal of Kidney Cancer and VHL, 2023 Although age younger than 46 years has been an independent criterion for genetic testing in hereditary renal cell carcinoma (hRCC), there is a lack of evidence in the literature.
Tomás Carminatti +6 more
doaj +3 more sources
Asian Journal of Urology, 2022 Objective: The aim of the current review is to summarize the available evidence to aid clinicians in the surveillance, treatment and follow-up of the different primary tumors developed by patients diagnosed with von Hippel-Lindau (VHL) syndrome. Methods:
Alessandro Larcher +24 more
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Loss of one copy of vhl in zebrafish facilitates hypoxia tolerance
Aquaculture Reports, 2023 Insufficient oxygen in the water (hypoxia) is one of the limiting factors for high-density culture in modern aquaculture. Hypoxia tolerance in fish has been reported to be related to the hypoxia-inducible factor (HIF)-α-mediated hypoxia signaling pathway.
Xueyi Sun +8 more
doaj +1 more source
Exploiting the circuit breaker cancer evolution model in human clear cell renal cell carcinoma
Cell Stress, 2020 The incessant interactions between susceptible humans and their respective macro/microenvironments registered throughout their lifetime result in the ultimate manifestation of individual cancers.
James J. Hsieh, Emily H. Cheng
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Hereditary Renal Cell Carcinoma Syndromes
Société Internationale d’Urologie Journal, 2022 A number of germline syndromes that predispose affected individuals to develop renal cancer have been described, each with unique manifestations, histopathology, and tumor behavior.
Jodie K. Maranchie +3 more
doaj +1 more source
The relationship between RSUME and VHL/HIF-1α signalling pathway in renal cell carcinoma
Archives of Medical Science, 2020 Introduction Renal cell carcinoma (RCC) is characterised by loss of the von Hippel-Lindau tumour suppressor gene (VHL), and the functional tumourigenic consequences of this loss have been used to develop therapies for advanced renal cell carcinoma, such ...
Yuanliang Wang +9 more
doaj +1 more source
An affinity-directed protein missile system for targeted proteolysis [PDF]
Open Biology, 2016 The von Hippel–Lindau (VHL) protein serves to recruit the hypoxia-inducible factor alpha (HIF1α) protein under normoxia to the CUL2 E3 ubiquitin ligase for its ubiquitylation and degradation through the proteasome.
Luke J. Fulcher +5 more
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Visual prognosis based staging for retinal capillary hemangioma
Российский офтальмологический журнал, 2020 Purpose. To analyze the literature to determine the visual prognosis of eyes affected by retinal angiomatosis of Von-Hippel Lindau disease (VHL). Study Type. Retrospective literature analysis. Methods.
G. Garg, P. T. Finger
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Germline genetic variants in pheochromocytoma/paraganglioma: single-center experience
Endocrine Oncology, 2023 Pheochromocytoma and paragangliomas (PPGLs) are rare neuroendocrine tumors carrying 25–40% pathogenic germline gene variants (PGVs). We evaluated clinical, laboratory, and germline molecular profile of 115 patients with pathologic (14 patients were ...
José V Lima Jr +6 more
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