Results 161 to 170 of about 52,478 (246)

PEG400 regulates Falcipain 2 activity through an allosteric mechanism

The FEBS Journal, EarlyView.
Falcipain‐2 can potentially be leveraged as a drug target due to its critical role as a haemoglobinase during the intra‐erythrocytic stage of Plasmodium falciparum. Here, we investigate the regulation of the proteolytic and haemoglobinase activity of falcipain‐2 in the presence of polyethylene glycol.
Bikram Nath, Subhoja Chakraborty, Sampa Biswas   +2 more
wiley   +1 more source

Iloperidone treatment mitigates the Juvenile Huntington's Disease phenotype possibly via Sigma‐1 Receptor Modulation

The FEBS Journal, EarlyView.
We investigated the potential of iloperidone as an activator of Sigma‐1 receptor (S1R) neuroprotective function in juvenile Huntington's disease (jHD). We tested iloperidone on cortical neurons differentiated from patient‐derived iPSCs, demonstrating that it acts as a S1R agonist, decreasing apoptosis, huntingtin aggregation, and oxidative stress ...
Ersilia Fornetti, Gaia Galluzzi, Mario Frezzini, Cécile Exertier, Vittorio Brufani, Gianni Colotti, Giancarlo Ruocco, Jessica Rosati, Angelo Luigi Vescovi, Daniele Narzi, Ilaria Genovese, Andrea Ilari   +11 more
wiley   +1 more source

Correction: Cattle on the rocks: Understanding cattle mobility, diet, and seasonality in the Iberian Peninsula: The Middle Neolithic site of Cova de les Pixarelles (Tavertet, Osona). [PDF]

PLoS One
Alcàntara Fors R, Madgwick R, Viñas-Caron LC, Nederbragt AJ, Saña Seguí M.   +4 more
europepmc   +1 more source

Toward understanding the catalytic mechanism for two classes of bacterial phospholipid N‐methyltransferases

The FEBS Journal, EarlyView.
Phospholipid N‐methyltransferases (Pmts) synthesize phosphatidylcholine in many bacteria. In this study, we compared the catalytic mechanisms of two bacterial Pmt classes: the Rhodobacter (R‐) and the Sinorhizobium (S‐) type. Representative enzymes for each class were derived from Rubellimicrobium thermophilum and Agrobacterium tumefaciens ...
Irina Shevyreva, Lena Sophie Fritsch, Leander Mika Koch, Anton Effing, Meriyem Aktas, Franz Narberhaus   +5 more
wiley   +1 more source

Coniferyl aldehyde from the phenylpropanoid pathway targets pyruvate kinase in Dactylobotrys graminicola to confer sheath rot resistance in hulless barley

Journal of Integrative Plant Biology, EarlyView.
Hulless barley resists the newly identified sheath rot disease caused by the necrotrophic fungal pathogen Dactylobotrys graminicola by releasing coniferyl aldehyde, a natural compound that disrupts energy production in the fungus. ABSTRACT Dactylobotrys graminicola (Dgr), a necrotrophic fungal pathogen, has recently been identified as the causative ...
Haowen Zheng, Liyifan Chen, Jianguo Wei, Yuandi Xu, Rangrang Chen, Yu Li, Yan Liu, Jiahui Yan, Lu Hou, Yiliang Chen, Zhensheng Kang, Haifeng Zhang, Qiang Yao   +12 more
wiley   +1 more source

Placental insufficiency markers to assess the risk of non-chromosomal genetic conditions in early-onset fetal growth restriction. [PDF]

Ultrasound Obstet Gynecol
Armengol-Alsina M, Bonacina E, Dalmau M, Temprado J, Valenzuela I, Codina-Solà M, Viñas-Jornet M, Rodó C, Mendoza M, Collaborators.   +9 more
europepmc   +1 more source

Auxin response and PIN‐mediated transport in chlorophyte algae

Journal of Integrative Plant Biology, EarlyView.
Like multicellular plants, green algae respond to auxin and move it across their cells. However, their PIN‐like proteins do not act like plant auxin exporters, suggesting that basic auxin transport evolved early and specialized directional transport appeared later in plant evolution.
Adrijana Smoljan, Sarah Koutnik‐Abele, Dmitrii Vladimirtsev, Petr Klíma, Anita Bírošíková, Yuzhou Zhang, Jack Merrin, Maximilian Schuster, Katarina Kurtović, Ulrich Z. Hammes, Jan Petrášek, Jiří Friml   +11 more
wiley   +1 more source

Projected Prevalence of Inadequate Nutrient Intakes in Europe

Annals of Nutrition and Metabolism, 2011
B. Román Viñas, L. Ribas Barba, J. Ngo, M. Gurinović, R. Novaković, A. Cavelaars, L. D. de Groot, P. van’t Veer, C. Matthys, L. Serra Majem   +9 more
semanticscholar   +1 more source

Voting Red Again: How Social Capital and Local Change Drove the Trump Swing

Journal of Regional Science, EarlyView.
ABSTRACT Social capital has long been regarded as a bulwark of democratic life. Yet in the United States—as across much of the democratic world—some of the communities with the densest social ties have proved the most receptive to antisystem politics.
Pedro Fierro, Andrés Rodríguez‐Pose, Francisco Rowe, Ellen Johanna Helsper   +3 more
wiley   +1 more source

Bortezomib-Induced Myocarditis in a Patient With Multiple Myeloma. [PDF]

JACC Case Rep
Domínguez-Linares A, Nieto-Dolores AK, Garcia-Cardenas M, Gonzalez-Trejo A, Ayala-Bustamante E, Valencia-Hernandez HA, Viñas-Mendieta A, Ruiz-Mori E, Espinola-Zavaleta N.   +8 more
europepmc   +1 more source