Results 181 to 190 of about 52,478 (246)

Therapeutic potential of small molecules that block receptor‐induced Kv7/M‐current suppression in neuroprotection, seizures, and pain

British Journal of Pharmacology, Volume 183, Issue 13, Page 3780-3795, July 2026.
Receptor‐induced Kv7/M‐current suppression increases neuronal activity and contributes to pathology of several conditions. A new class of Kv7 modulators identified in this study attenuates M‐current suppression and shows therapeutic effects. Abstract Background and Purpose Neuronal Kv7 channels generate low voltage–gated potassium currents known as the
Young Woo Kim, Pavan Kumar Behara, Lamees Alhassen, Cindy Wong, Olivier Civelli, Naoto Hoshi   +5 more
wiley   +1 more source

Calidad de la información sobre productos médicos ilegales: clave para proteger la salud pública. [PDF]

Rev Panam Salud Publica
Alfonso Arvez MJ, Rojas-Cortés R, Vahos J, Viñas R, Baldut M, Romero F, Ramírez J, Miriam M, González F, Carrasco G.   +9 more
europepmc   +1 more source

Design and Synthesis of Pyrimidino[4,5‐d]Pyrimidine‐Based Compounds as Potent B‐RAF V600E Inhibitors

ChemMedChem, Volume 21, Issue 11, 15 June 2026.
Novel pyrimido[4,5‐d]pyrimidine‐based inhibitors selectively target B‐RAF V600E with nanomolar affinity and adopt distinct type‐II binding modes. Complementary cellular profiling reveals highly active analogs, underscoring the versatility of this chemotype and establishing it as a promising scaffold for the development of next‐generation kinase ...
Eleftheria A. Georgiou, Kalliopi Christopoulou, Amalia D. Kalampaliki, Aikaterini F. Giannopoulou, Eleftheria Chatziorfanou, Vivi Bafiti, Andreas Krämer, Athanasios Papakyriakou, Dimitrios J. Stravopodis, Stefan Knapp, Ioannis K. Kostakis   +10 more
wiley   +1 more source

Antagonistic Potential of Agro-Industrial Byproduct-Derived Lactic Acid Bacteria Against Mycotoxigenic <i>Aspergillus flavus</i> and <i>Fusarium verticillioides</i>. [PDF]

Int J Microbiol
Wu-Wu JWF, Barboza N, Villalta-Romero F, Viñas M.   +3 more
europepmc   +1 more source

Synthesis and Evaluation of Aromatic Sulfonamide and Disulfonamide Derivatives as Dengue Virus NS3–NS5 Interaction Inhibitors

ChemMedChem, Volume 21, Issue 11, 15 June 2026.
A synthetic methodology for the preparation of asymmetric benzene‐1,4‐disulfonamides was developed and applied to generate potential anti‐dengue virus (DENV) compounds. Guided by computer‐assisted structural rationalization, we designed synthetically more accessible analogs with reduced toxicity that interact with the DENV NS5 domain, thereby ...
Jakub Janáč, Jan Drahorád, Jakub Harvalík, Tereza Horáčková, Manfred Brinker, Arianna Loregian, Andrea Brancale, Beatrice Mercorelli, Petra Cuřínová   +8 more
wiley   +1 more source

Correction to 'Nuclear ubiquitination by FBXL5 modulates Snail1 DNA binding and stability'. [PDF]

Nucleic Acids Res
europepmc   +1 more source

Inhibitory Effect of Trichoderma longibrachiatum on Growth of Fusarium Species and Accumulation of Fumonisins. [PDF]

J Fungi (Basel)
Zhu R, Li Y, Viñas M, Kong Q, Xu M, Zhang X, Song X, He K, Guo Z.   +8 more
europepmc   +1 more source

DNA‐Binding Properties of Iridium(III) Complexes Encompassing Design, Function and Biophysical Assessments

ChemPhysChem, Volume 27, Issue 11, 15 June 2026.
This review describes the biophysical techniques used to investigate DNA‐binding phenomena and the progress made so far in the application of iridium(III) complexes for this purpose. Ir(III) complexes offer myriad opportunities in the design and study of DNA‐binding agents and discussed examples are contextualised with complementary studies in ...
Ibrahim S. Alkhaibari, Niklaas J. Buurma, Simon J. A. Pope   +2 more
wiley   +1 more source

Short Antimicrobial Peptides Based on Arginine and Tryptophan: Agents with Potential in Combating Resistant Pathogens. [PDF]

ACS Omega
de la Cruz EF, Mhlongo JT, Kumar A, Albericio F, Viñas M, Espinal P, Fusté E, de la Torre BG.   +7 more
europepmc   +1 more source

Targeting Fatty Acid Synthase With Berberine Promotes IL‐10 Production in Macrophages and Prevents Relapse in a Murine Colitis Model

The FASEB Journal, Volume 40, Issue 11, 15 June 2026.
Berberine enhances IL‐10 production in macrophages via FASN‐dependent mechanisms, thereby promoting epithelial repair and preventing colitis relapse. Created with BioRender.com. ABSTRACT Inflammatory bowel disease (IBD) is a chronic inflammatory disorder characterized by alternating periods of remission and relapse.
Shusaku Hayashi, Yudai Ogawa, Nonoka Wakabayashi, Koga Tokuyama, Makito Oku, Takeshi Yamamoto, Shinichi Kato, Asma Nusrat, Makoto Kadowaki   +8 more
wiley   +1 more source