Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer
Molecular Oncology, EarlyView.Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba +5 more
wiley +1 more source
Increasing Recall of Lengthening Detection via Semi-Automatic Classification [PDF]
, 2017 Betz S, Voße J, Zarrieß S, Wagner P. Increasing Recall of Lengthening Detection via Semi-Automatic Classification. In: Proceedings of Interspeech.
Betz, Simon ; https://orcid.org/ +3 more
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Molecular Oncology, EarlyView.LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David +12 more
wiley +1 more source
Hyperspectral colon tissue cell classification [PDF]
, 2004 A novel algorithm to discriminate between normal and malignant tissue cells of the human colon is presented. The microscopic level images of human colon tissue cells were acquired using hyperspectral imaging technology at contiguous wavelength intervals ...
Rajpoot, Nasir M. (Nasir Mahmood) +2 more
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Using the VIA Classification to Advance a Psychological Science of Virtue. [PDF]
Front Psychol, 2020 McGrath RE, Brown M.
europepmc +1 more source
Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy
Molecular Oncology, EarlyView.LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir +9 more
wiley +1 more source
The constructing and use of faceted classification schema in technical domains
Examines the construction and use of faceted classification schema in technical domains.Source type: Electronic ...
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Predicting functional performance via classification of lower extremity strength in older adults with exergame-collected data. [PDF]
J Neuroeng Rehabil, 2020 Becker H +5 more
europepmc +1 more source
Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma
Molecular Oncology, EarlyView.Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara +10 more
wiley +1 more source
Towards classification of ovarian cancer via micro-arrays data analysis
, 2020 The classification of micro-arrays data relative toovarian cancer is approached without using any a prioriinformation via a specially designed technique, consisting ofcascading two clustering algorithms, namely PDDP, recalled,and well known K-means. Then
diego liberati
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