Results 41 to 50 of about 1,581,972 (289)

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Agriculture Viability Grants Program : [application] 2019.

, 2019
Annual; "Farm Viability Grant, Farm Transition Grant."; Funding for the State of Connecticut agriculture viability grants was established in 2005 through Public Act 05-228, an Act Concerning Farm Land Preservation, Land Protection, Affordable Housing and
Agriculture Viability Grants Program (Conn.)
core   +1 more source

Integrating Transcriptomics and 3D Spheroid Models Reveals Microenvironment-Dependent Purinergic Modulation in Hepatocellular Carcinoma

Metabolites
Background/Objectives: Dysregulation of purinergic signaling, particularly CD73 overexpression, influences tumor progression, immune evasion, and chemoresistance in hepatocellular carcinoma (HCC). We aimed to characterize the transcriptional landscape of
Arieli Cruz de Sousa, Augusto Ferreira Weber, Vinícius Klain, Juliete Nathali Scholl, Jéssica Marques Obelar Ramos, Natália Baltazar do Nascimento, Maria Luiza Giehl, Renata Kruger Martins, João Vitor Heres, Camila Kehl Dias, Renata Marschner, Fabrício Figueiró, Fátima Costa Rodrigues Guma   +12 more
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Agriculture Viability Grants Program [application] 2016.

, 2016
Annual; "Farm Viability Grant, Farm Transition Grant."; Funding for the State of Connecticut agriculture viability grants was established in 2005 through Public Act 05-228, an Act Concerning Farm Land Preservation, Land Protection, Affordable Housing and
Agriculture Viability Grants Program (Conn.)
core   +1 more source

Varietal and germinative characterization of Agave potatorum (Asparagaceae) seeds with different origins

Botan‪ical Sciences, 2018
Background: Agave potatorum reproduces mainly through seeds is widely collected for the mezcal production, and there is currently a marked decrease in their wild populations.
Yolanda Donají Ortiz-Hernández, Germán Fernando Gutiérrez-Hernández, Luis Jorge Corzo-Ríos, Elpidio García-Ramírez, Sabino Honorio Martínez-Tomás   +4 more
doaj   +1 more source

Effects of different shrimp extracts on Vibrio parahaemolyticus growth and virulence

Vietnam Journal of Science, Technology and Engineering, 2022
Vibrio parahaemolyticus is the main causative agent of acute hepatopancreatic necrosis disease (AHPND) in shrimp. This study aimed to investigate how shrimp extracts affect the growth and virulence of an AHPND-causative strain known as V ...
Nguyen Thuan Thien Truong, The Hao Nguyen, Cong Chinh Bui, Thi Thu Hoai Nguyen   +3 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

The world’s largest potato cryobank at the International Potato Center (CIP) – Status quo, protocol improvement through large-scale experiments and long-term viability monitoring

Frontiers in Plant Science, 2022
Long-term conservation of Plant Genetic Resources (PGR) is a key priority for guaranteeing food security and sustainability of agricultural systems for current and future generations.
Rainer Vollmer, Rosalva Villagaray, Mario Castro, José Cárdenas, Sandra Pineda, Janeth Espirilla, Noelle Anglin, Noelle Anglin, Dave Ellis, Vânia Cristina Rennó Azevedo   +9 more
doaj   +1 more source