Results 61 to 70 of about 112,273 (227)

Antagonism toward the intestinal microbiota and its effect on Vibrio cholerae virulence

Science, 2018
Cholera pathogen zaps competition Many bacterial pathogens inject their hosts with virulence effectors delivered by specialist secretion machines. Vibrio cholerae has a type VI secretion system (T6SS) that can be loaded with protein toxins that target ...
Wenjing Zhao, Florence Caro, W. Robins, J. Mekalanos   +3 more
semanticscholar   +1 more source

Improving the learning experience in an undergraduate course on microbial metabolism by using an illustrated story

Biochemistry and Molecular Biology Education, Volume 53, Issue 2, Page 131-141, March/April 2025.
Abstract In the classroom, metabolism is often approached and received as a mundane exercise in memorization. Teaching metabolism also faces the challenge of negative perceptions that can impede learning. We sought to improve the learning experience in an undergraduate lecture course on microbial metabolism by implementing an illustrated story that ...
James B. McKinlay, Katherine Kearns
wiley   +1 more source

Direct activation of a phospholipase by cyclic GMP-AMP in El Tor Vibrio cholerae

Proceedings of the National Academy of Sciences of the United States of America, 2018
Significance Second messengers are employed by all organisms to regulate fundamental behaviors, including biofilm formation, motility, metabolism, and pathogenesis in bacteria.
Geoffrey B. Severin, M. Ramliden, Lisa A Hawver, Kun Wang, M. E. Pell, Ann-Katrin Kieninger, Atul Khataokar, Brendan J. O’Hara, Lara V. Behrmann, M. Neiditch, C. Benning, C. Waters, Wai‐Leung Ng   +12 more
semanticscholar   +1 more source

Characterization of the Immune Response after Oral Cholera Vaccination (OCV) and Effects of Mycophenolate Mofetil on Priming of this Immune Response—A Randomized, Placebo‐Controlled Trial

Clinical Pharmacology &Therapeutics, EarlyView.
Mycophenolate mofetil (MMF) is an immunosuppressive drug widely used by solid organ transplant recipients. Although it is known that MMF suppresses immune responses, its exact effects on specific vaccinations have not been investigated yet. Mucosal vaccinations are increasingly used, such as a cholera vaccination consisting of two oral immunizations ...
Boukje C. Eveleens Maarse, Aliede E. in 't Veld, Hendrika W. Grievink, Manon A.A. Jansen, Matthijs Moerland   +4 more
wiley   +1 more source

Engineering Bacteria for Medicine: Delivery, Diagnosis, and Therapy

iMetaMed, EarlyView.
ABSTRACT With rapid advances in synthetic biology and genetic engineering, genetically engineered bacteria (GEB) have emerged as a promising platform for biological therapy, addressing key limitations of conventional drug delivery systems and demonstrating significant clinical potential.
Shiyu Xia, Guiling Fu, Xiaoyue Ding, Wen Yang, Ruijie Bai, Yawei Cai, Jing xuan Zhang, Yanxia Wei, Conghui Han, Yi‐Zhou Gao, Ying Li, Zuobin Zhu   +11 more
wiley   +1 more source

Detection of viable and viable nonculturable Vibrio cholerae O1 through cultures and immunofluorescence in the Tucumán rivers, Argentina Detecção de Vibrio cholerae O1 viável e viável não cultivável, através de técnicas de cultivo e imunofluorescência nos rios de Tucumán, Argentina

Revista da Sociedade Brasileira de Medicina Tropical, 2007
Vibrio cholerae has been sporadically isolated from rivers in Tucumán, Argentina, since the outbreak in 1991. The aim of this study was to determine the environmental reservoir of the bacterium in these rivers, assessing the presence of Vibrio cholerae ...
Olga Aulet, Clara Silva, Sol González Fraga, Mariana Pichel, Rosa Cangemi, Cristina Gaudioso, Norma Porcel, Maria Angela Jure, Marta Cecilia de Castillo, Noma Binsztein   +9 more
doaj   +1 more source

Catabolism of mucus components influences motility of Vibrio cholerae in the presence of environmental reservoirs. [PDF]

PLoS ONE, 2018
Vibrio cholerae O1, the etiological agent of cholera, is a natural inhabitant of aquatic ecosystems. Motility is a critical element for the colonization of both the human host and its environmental reservoirs. In this study, we investigated the molecular
Geethika Reddi, Kali Pruss, Kathryn L Cottingham, Ronald K Taylor, Salvador Almagro-Moreno   +4 more
doaj   +1 more source

Exopolysaccharide protects Vibrio cholerae from exogenous attacks by the type 6 secretion system

Proceedings of the National Academy of Sciences of the United States of America, 2018
Significance This work demonstrates that exopolysaccharide (EPS) produced by Vibrio cholerae can protect against exogenous type 6 secretion system (T6SS) attacks from different bacterial species.
J. Toska, B. Ho, J. Mekalanos
semanticscholar   +1 more source

Strategies and mechanisms of precision genome engineering: From gene editing to genome writing

iMetaOmics, EarlyView.
In this review, we examined the progression of genome manipulation from stochastic nuclease‐mediated cutting toward precise editing and programmable genome writing. We discussed tools like multi‐kilobase RNA‐guided integrators and Artificial Intelligence (AI)‐designed effectors and showed how these advances enable researchers to treat genomes as ...
Kerui Huang, Jianhong Tian, Wenyan Zhao, Siqin Zhang, Lixuan Xiang, Meiqing Yang, Lu Liu, Yazhou Huang, Ningyun Zhang, Lei Sun, Peng Xie, Nanyu Kuang, Hong Zhou, Chengfeng Qiu, Jun Yan, Xiaocheng Jiang, Qiang Tu, Yun Wang, Haoliang Hu, Youming Zhang   +19 more
wiley   +1 more source

The ins and outs of cyclic di-GMP signaling in Vibrio cholerae

Current Opinion in Microbiology, 2017
The second messenger nucleotide cyclic dimeric guanosine monophosphate (c-di-GMP) governs many cellular processes in the facultative human pathogen Vibrio cholerae.
Jenna G Conner, David Zamorano-Sánchez, J. Park, H. Sondermann, F. Yildiz   +4 more
semanticscholar   +1 more source