Results 231 to 240 of about 64,101 (304)

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

The impact of parental intimate partner violence and abuse (IPVA) on young adult relationships: a UK general population cohort study. [PDF]

Lancet Reg Health Eur
Herbert A, Barter C, Szilassy E, Heron J, Fraser A, Barnes M, Yakubovich AR, Feder G, Howe LD.   +8 more
europepmc   +1 more source

Reparations for Victims of Gross and Systematic Human Rights Violations: The Notion of Victim [PDF]

, 2003
Robouts, Heidy, Vandeginste, Stef
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Developmentally Tailored Telehealth-Delivered Cognitive-Behavioural Therapy for Adolescents with Body Dysmorphic Disorder: A Multiple Baseline Design. [PDF]

Res Child Adolesc Psychopathol
Lavell CH, Oar EL, M Rapee R.
europepmc   +1 more source

Bullying today: a report by the Office of the Children's Commissioner, with recommendations and links to practitioner tools [PDF]

, 2006

core  

Crime victims in the European Union. Reflexions on standards and action. Communication from the Commission to the Council, the European Parliament and the Economic and Social Committee. COM (99) 349 final, 14 July 1999 [PDF]

, 1999

core  

Adolescents' Self and Bullying Victimisation: The Key Role of Gender. [PDF]

Children (Basel)
Perazzini M, Bontempo D, Giancola M, D'Amico S, Perilli E.   +4 more
europepmc   +1 more source

The syndemic of incarceration, violence victimisation, needle/syringe sharing, & HIV infection: A population-based study of men who inject drugs in India. [PDF]

Indian J Med Res
Chakrapani V, P V M L, Tsai AC, Purayil VP, Kumar P, Kumar R, Das C, Rajan S.   +7 more
europepmc   +1 more source