Results 121 to 130 of about 34,013 (266)

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

The Impact of Bullying Victimization on School Adjustment: A Moderated Mediation Model. [PDF]

Behav Sci (Basel)
Chen H, Wang Y, Lu T, Zhou Q, Chen H, Liang Q, Zhang C, Yan J.   +7 more
europepmc   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Neurodevelopmental associations linking subtypes of bullying victimization to internalizing and externalizing problems in childhood and adolescence. [PDF]

Dev Cogn Neurosci
Wang Z, Zhang L, Ji L, Chen L, Zhang K, Cao Y, Zhang W.   +6 more
europepmc   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Why Do Victimized Youth Feel Lonely? Cognitive Flexibility as a Mediator and Social Support as a Contextual Moderator. [PDF]

J Sch Health
Liang P, Yan Y, Wen X, Liu X.
europepmc   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

How Is Bullying Victimization Associated with Depressive Symptoms Among Multicultural Adolescents in South Korea? A Serial Mediation and Network Analysis of Acculturative Stress and Ego-Resiliency. [PDF]

Behav Sci (Basel)
Jiang Z, Li X, Park BY, Chen M.
europepmc   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

The serial effect of bullying victimization and aggression outcome expectancies on within-person changes in proactive aggression among adolescents across one year. [PDF]

J Res Adolesc
Lin J, Xia LX.
europepmc   +1 more source