Results 201 to 210 of about 192,329 (243)

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Victimizer, Victim and Self-Victimization : Thomas Pynchon's V.

Victimizer, Victim and Self-Victimization : Thomas Pynchon's V.
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Childhood Victimization and Crime Victimization

Journal of Interpersonal Violence, 2010
The purpose of this study is to determine whether abused and neglected children are at increased risk for subsequent crime victimization. We ask four basic questions: (a) Does a history of child abuse/neglect increase one’s risk of physical, sexual, and property crime victimization?
Jared Kean, McIntyre, Cathy Spatz, Widom
openaire   +2 more sources

Is a victim a victim a victim?

Criminal Justice Matters, 1997
Comparative research, as is well known, is thwart with difficulties. Give those difficulties Nelken (1994) is right to ask the question, ‘What is the point of doing research in comparative criminology?’ The same question might well be asked of victimology.
Sandra Walklate, Rob Allan
openaire   +1 more source

Victims Becoming Victimizers

2018
It may seem unthinkable for sex trafficking victims to eventually become the traffickers who recruit victims into the same industry of abuse, pain, and exploitation that they had been forced to endure, it is important to understand that the identities of victims and perpetrators are not distinctly separate from one another (Siegel and Blank, Global ...
Natalie Sarachaga-Barato, Lenore Walker
openaire   +1 more source

Victims and second victims

2021
When patients are harmed, staff often get blamed — especially when nobody realizes how digital systems go wrong and create the problems.
openaire   +1 more source

Victim to Victimizer

Journal of Interpersonal Violence, 1989
Victims of childhood sexual abuse may experience many dysfunctional outcomes. One negative outcome may be an increased risk of the sexually abused becoming sexually abusive to others. This article suggests that experience in the treatment of sexual offenders may have important implications for how we treat victims of child sexual abuse in order to ...
openaire   +1 more source