Results 181 to 190 of about 54,487 (245)

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

A VICTIM IS A VICTIM IS A VICTIM?: Chronic Victimization in Four Sweeps of the British Crime Survey

, 1995
Ellingworth, D, Farrell, G, Pease, K
openaire   +1 more source

Victimizer, Victim and Self-Victimization : Thomas Pynchon's V.

Victimizer, Victim and Self-Victimization : Thomas Pynchon's V.
openaire   +1 more source

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Is a victim a victim a victim?

Criminal Justice Matters, 1997
Comparative research, as is well known, is thwart with difficulties. Give those difficulties Nelken (1994) is right to ask the question, ‘What is the point of doing research in comparative criminology?’ The same question might well be asked of victimology.
Sandra Walklate, Rob Allan
openaire   +1 more source

Poly-victimization: A neglected component in child victimization

Child Abuse and Neglect, 2007
Objective: To assess the role of multiple victimization, or what is termed in this article poly-victimization, in explaining trauma symptomatology. Method: In a nationally representative sample of 2,030 children ages 2-17, assessment was made of the ...
David Finkelhor, Heather A Turner, Richard Ormrod   +2 more
exaly   +2 more sources

Childhood Victimization and Crime Victimization

Journal of Interpersonal Violence, 2010
The purpose of this study is to determine whether abused and neglected children are at increased risk for subsequent crime victimization. We ask four basic questions: (a) Does a history of child abuse/neglect increase one’s risk of physical, sexual, and property crime victimization?
Jared Kean, McIntyre, Cathy Spatz, Widom
openaire   +2 more sources

The process of victimization: The victims' perspective

Child Abuse & Neglect, 1990
Twenty-three child victims (aged 10-18 years) of childhood sexual abuse were interviewed about the victimization process, the person who abused them, and how abuse might have been prevented. Specific questions obtained information about the quality of the relationship between victim and offender, the offender's pre-abuse behavior, the explanation for ...
L, Berliner, J R, Conte
openaire   +2 more sources

Profiles of non‐victims, escaped victims, continuing victims and new victims of school bullying

British Journal of Educational Psychology, 2004
Background: Victims of school bullying are known to be at risk in peer relationships and to sometimes use ineffective coping strategies, but little previous research has examined differences among escaped victims, continuing victims and new victims.
Smith, PK, Talamelli, L, Cowie, H, Naylor, P, Chauhan, P   +4 more
openaire   +4 more sources