Facial herpes vegetans in a person living with human immunodeficiency virus with undetectable viral load. [PDF]
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To the Editor.— Previously we described two patients who were treated with vidarabine (adenine arabinoside) for chronic hepatitis B infection (239:1648, 1978). Since this report we have treated 13 other patients with similar regimens. A summary of side effects related to this drug in all 15 patients follows.
S L, Sacks +7 more
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Hematologic Abnormalities Associated with Vidarabine
Drug Intelligence & Clinical Pharmacy, 1984A report of hematologic abnormalities associated with administration of vidarabine in a neonate is presented. High doses of vidarabine (30 mg/kg/d) for the treatment of herpes simplex infection may have caused a decrease in hematocrit and platelet count. This case demonstrates the need to monitor hematologic indices during administration of vidarabine.
R A, Lyon, S, Swigart
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Stability-Indicating Assay for Vidarabine
Journal of Pharmaceutical Sciences, 1979A physicochemical procedure for the analysis of vidarabine in aqueous parenteral formulations was needed to assure potency and to define stability. Concurrent with the development of this method, its decomposition products and route in aqueous solution were determined.
W H, Hong, D H, Szulczewski
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Treatment of Vaccinial Keratitis With Vidarabine
Archives of Ophthalmology, 1976Vaccinial epithelial keratitis was produced in rabbits. When the therapeutic effect of vidarabine on the experimentally-induced disease was evaluated and compared to the effect of idoxuridine, vidarabine was found to be highly effective, substantially more effective than idoxuridine, and nontoxic to the eye.
R A, Hyndiuk +4 more
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Vidarabine-Loaded Nanoparticles: A Physicochemical Study
Pharmaceutical Research, 1990The chemical reaction of vidarabine (VIDA) with isohexyl cyanoacrylate nanoparticles in a pH-dependent fashion occurs only in the presence of dioctylsulfosuccinate (DOSS). The formation of an ion pair with DOSS allows a better contact of VIDA with the monomer during the polymerization process taking place in micelles.
V, Guise +5 more
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