Results 71 to 80 of about 2,726 (170)

Therapeutic trials for a rabbit model of EBV-associated Hemophagocytic Syndrome (HPS): Effects of vidarabine or CHOP, and development of Herpesvirus papio (HVP)-negative lymphomas surrounded by HVP-infected lymphoproliferative disease [PDF]

, 2003
Epstein-Barr virus-associated hemophagocytic syndrome (EBV-AHS), which is often associated with fatal infectious mononucleosis or T-cell lymphoproliferative diseases (LPD), is a distinct disease characterized by high mortality. Treatment of patients
Koirala, T.R., Jin, Z.S., Tanaka, T., Ohara, N., Kondo, E., Oda, W., Yoshino, T., Yamada, M., Joko, H., Takahashi, K., Hayashi, K., Oka, T., Munemasa, M., Akagi, T., Onoda, S.   +14 more
core  

Ganciclovir ophthalmic gel 0.15% for the treatment of acute herpetic keratitis: background, effectiveness, tolerability, safety, and future applications

Therapeutics and Clinical Risk Management, 2014
Timothy Y Chou, Bennett Y Hong Department of Ophthalmology, Stony Brook University, Stony Brook, NY, USA Abstract: Eye disease due to herpes simplex virus (HSV) is a leading cause of ocular morbidity and the number one infectious cause of unilateral ...
Chou TY, Hong BY
doaj  

A green synthesis of vidarabine 5’-monophosphate via a one-pot multienzymatic reaction catalyzed by immobilized biocatalysts

, 2015
In nature, enzyme cascades can be found in many metabolic pathways. The idea of using multienzymatic systems to mimic these processes is gaining interest for production of chemical compounds. A type of multi-enzymatic application is the use of multiple
CATTANEO, GIULIA, UBIALI, DANIELA, TERRENI, MARCO, SERRA, IMMACOLATA, BAVARO, TEODORA, Christiansen, Louise Slot, Alcantara, Andres R., Robescu, Marina S., Taboada, Alba Fresco, Piškur, Jure   +9 more
core  

Kinetic analysis of UPP1 using Lineweaver-Burk plots.

, 2012
Uridine was used as substrate (50 to 375 µM) and vidarabine was as inhibitor at 500 µM (?), 250 µM (?), and 100 µM (▴) and 0 µM (⧫).
Louise Egeblad (161722), Jan Balzarini (161754), Pär Nordlund (161768), Staffan Eriksson (161760), Liya Wang (161745), Martin Welin (161726), Susanne Gräslund (161738), Susanne Flodin (161732)   +7 more
core   +1 more source

An innovative synthesis of the antiviral Vidarabine through the dual use of flow chemistry and biocatalysis

, 2019
Nucleoside analogues are synthetic, chemically modified compounds that have been developed to mimic their physiological counterparts and act as antimetabolites, thus impairing cellular division and viral replication.
F. Rinaldi, G. Speranza, T. Bavaro, D. Ubiali, F. Annunziata, C. Previtali, P. Conti, L. Tamborini, E. Calleri   +8 more
core  

Clinical Review of Risk of Nephrotoxicity with Acyclovir Use for Treatment of Herpes Simplex Virus Infections in Neonates and Children. [PDF]

J Pediatr Pharmacol Ther, 2023
ElHassan NO, Crawford B, Alamarat Z, Painter JT.   +3 more
europepmc   +1 more source

Characterization of a Purine Nucleoside Phosphorylase From Colwellia sp. WH041 for Multienzyme Synthesis of Nucleoside Analogs. [PDF]

Chembiochem
Wang S, Zhang Y, Yang F, Chen F, Shao X, Liu G, Wu B.   +6 more
europepmc   +1 more source

A novel corneal epithelial cell culture assay for assessing topical antivirals against herpes simplex virus keratitis. [PDF]

Biochem Biophys Rep
Kuniyoshi H, Numata Y, Sasano M, Hayashi H, Fuse N, Sarafianos SG, Kodama EN.   +6 more
europepmc   +1 more source

A bacteria-based search for drugs against avian and swine flu yields a potent and resistance-resilient channel blocker. [PDF]

Proc Natl Acad Sci U S A
Lahiri H, Israeli E, Krugliak M, Basu K, Britan-Rosich Y, Ravins Yaish T, Arkin IT.   +6 more
europepmc   +1 more source

Continuous Flow Chemistry: A Novel Technology for the Synthesis of Marine Drugs. [PDF]

Mar Drugs, 2023
Peña LF, González-Andrés P, Parte LG, Escribano R, Guerra J, Barbero A, López E.   +6 more
europepmc   +1 more source