Results 51 to 60 of about 2,726 (170)

Regioselective Deacetylation in Nucleosides and Derivatives

ChemBioChem, Volume 25, Issue 23, December 2, 2024.
Selective deprotection of the acetyl group(s) in acetylated nucleosides demonstrates practical significance in synthetic processes. It simplifies the preparation of partially or differentially substituted nucleoside intermediates. In this mini‐review, we summarized and evaluated recent approaches for regioselective deacetylation in acetylated ...
Charis Grabbe, Li Cai
wiley   +1 more source

Uncovering the Potent Antiviral Activity of the Sesterterpenoids from the Sponge Ircinia Felix Against Human Adenoviruses: from the Natural Source to the Total Synthesis

Chemistry – A European Journal, Volume 30, Issue 66, November 26, 2024.
Isolation, structure elucidation, biological activity, and total synthesis of ircinialactam J, a novel sesterterpene lactam produced by the sponge Ircinia felix, is presented. Ircinialactam J displays a significant antiviral activity against Human Adenoviruses (11 times more active than cidofovir®) without cytotoxicity.
Ana Ruiz‐Molina, Dawrin Pech‐Puch, Ramón E. Millán, Lucía Ageitos, Harold Villegas‐Hernández, Jerónimo Pachón, José Pérez Sestelo, Javier Sánchez‐Céspedes, Jaime Rodríguez, Carlos Jiménez   +9 more
wiley   +1 more source

Early-onset herpes simplex encephalitis type 1 triggered by COVID-19 disease: A case report

Radiology Case Reports
Coronavirus disease 2019 (COVID-19) causes a systemic inflammatory response and a temporary immunosuppression of hosts. Several reports have showed that reactivation of herpes simplex virus type 1 (HSV-1) is strongly associated with COVID-19.
Kai Inoue, Hanako Aoki, Shuta Toru, Yu Hatano, Reina Imase, Hiroshi Takasaki, Michiko Tanaka, Saori Adachi, Hiroaki Yokote, Hideki Akiyama, Michio Yamane   +10 more
doaj   +1 more source

Synthesis of Nucleosides`s Analogues and their Application as Chemotherapeutic Agents

Eurasian Chemico-Technological Journal, 2013
Application of the chemical-enzyme approach which is a combination of chemical synthesis and enzyme reaction has allowed to develop original effective methods of synthesis both new compounds and known nucleoside antibiotics which have been inaccessible ...
E. N. Kalinichenko
doaj   +1 more source

Antiviral Lead Compounds from Marine Sponges

Marine Drugs, 2010
Marine sponges are currently one of the richest sources of pharmacologically active compounds found in the marine environment. These bioactive molecules are often secondary metabolites, whose main function is to enable and/or modulate cellular ...
Kenneth P. Minneman, Mandeep Kaur, Sunil Sagar   +2 more
doaj   +1 more source

Management of oral herpes simplex virus infections: The problem of resistance. A narrative review

Oral Diseases, Volume 30, Issue 3, Page 877-894, April 2024.
Abstract Herpes Simplex Virus (HSV) type 1 (HSV‐1) and type 2 (HSV‐2) are among the most common human viral pathogens, affecting several billion people worldwide. Although in healthy patients clinical signs and symptoms of HSV infection are usually mild and self‐limiting, HSV‐infections in immunocompromised patients are frequently more aggressive ...
Evangelia Piperi, Erofili Papadopoulou, Maria Georgaki, Sara Dovrat, Mor Bar Illan, Nikolaos G. Nikitakis, Noam Yarom   +6 more
wiley   +1 more source

Vidarabine-associated encephalopathy and myoclonus [PDF]

Antimicrobial Agents and Chemotherapy, 1986
A 24-year-old man with disseminated herpes zoster, which occurred 9 months after bone marrow transplantation for chronic myeloid leukemia, developed encephalopathy and immobilizing myoclonus after 7 days of vidarabine treatment (10 mg/kg of body weight per day). Only mild hepatic dysfunction was a risk factor for a toxic reaction.
openaire   +2 more sources

The Antiviral Effect of Two Important Base Analogs, Ribavirin and 5‐Fluoruracil, on Infectious Pancreatic Necrosis Virus

Aquaculture Research, Volume 2024, Issue 1, 2024.
Infectious pancreatic necrosis (IPN) has highly contagious disease and an important viral disease‐causing economic loss for fish farming, which has developed in recent years. The virus is the first fish virus isolated in vitro. Horizontal and vertical transmission plays an important role in the spread of the virus.
Yasemin Çiçek Yıldız, Zafer Yazıcı, Christyn Bailey   +2 more
wiley   +1 more source

Antiviral Activity of Nitazoxanide and Miltefosine Against FeHV‐1 In Vitro

Veterinary Medicine International, Volume 2024, Issue 1, 2024.
Feline herpesvirus type 1 (FeHV‐1) is a primary pathogen in cats responsible for respiratory and ocular signs. There are presently no antiviral drugs that are officially licensed for veterinary use in several countries. Consequently, veterinarians must depend on off‐label antivirals designed for human use. Recent advances in virus–host cell interaction
Consiglia Longobardi, Gianmarco Ferrara, Sara Damiano, Salvatore Florio, Giuseppe Iovane, Ugo Pagnini, Serena Montagnaro, Roberto Ciarcia, Imtiaz Rabbani   +8 more
wiley   +1 more source

Chiral coordination polymer nanowires boost radiation-induced in situ tumor vaccination

Nature Communications
Radiation-induced in situ tumor vaccination alone is very weak and insufficient to elicit robust antitumor immune responses. In this work, we address this issue by developing chiral vidarabine monophosphate-gadolinium nanowires (aAGd-NWs) through ...
Zhusheng Huang, Rong Gu, Shiqian Huang, Qian Chen, Jing Yan, Xiaoya Cui, Haojie Jiang, Dan Yao, Chuang Shen, Jiayue Su, Tao Liu, Jinhui Wu, Zhimin Luo, Yiqiao Hu, Ahu Yuan   +14 more
doaj   +1 more source