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Stability-Indicating Assay for Vidarabine
Journal of Pharmaceutical Sciences, 1979A physicochemical procedure for the analysis of vidarabine in aqueous parenteral formulations was needed to assure potency and to define stability. Concurrent with the development of this method, its decomposition products and route in aqueous solution were determined.
W H, Hong, D H, Szulczewski
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Treatment of Vaccinial Keratitis With Vidarabine
Archives of Ophthalmology, 1976Vaccinial epithelial keratitis was produced in rabbits. When the therapeutic effect of vidarabine on the experimentally-induced disease was evaluated and compared to the effect of idoxuridine, vidarabine was found to be highly effective, substantially more effective than idoxuridine, and nontoxic to the eye.
R A, Hyndiuk +4 more
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2000
Abstract conventional doses of short-term vidarabine therapy are few and minor; they include rash, inappropriate antidiuretic hormone secretion, leukopenia, and thrombocytopenia (7). Neurotoxicity has been consistently associated with high dose, long-term vidarabine therapy; coadministration of interferon may enhance the nervous ...
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Abstract conventional doses of short-term vidarabine therapy are few and minor; they include rash, inappropriate antidiuretic hormone secretion, leukopenia, and thrombocytopenia (7). Neurotoxicity has been consistently associated with high dose, long-term vidarabine therapy; coadministration of interferon may enhance the nervous ...
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Vidarabine-Loaded Nanoparticles: A Physicochemical Study
Pharmaceutical Research, 1990The chemical reaction of vidarabine (VIDA) with isohexyl cyanoacrylate nanoparticles in a pH-dependent fashion occurs only in the presence of dioctylsulfosuccinate (DOSS). The formation of an ion pair with DOSS allows a better contact of VIDA with the monomer during the polymerization process taking place in micelles.
V, Guise +5 more
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Formulation of a stable vidarabine infusion fluid
Pharmaceutisch Weekblad Scientific Edition, 1983Decomposition of vidarabine in a 5% glucose infusion fluid after steam sterilization was measured by HPLC and TLC analysis. After sterilization for 60 minutes at 100 degrees C and 20 minutes at 120 degrees C no degradation could be observed. A slight but significant degradation was observed after sterilization for 60 minutes at 120 degrees C followed ...
L M, Stolk +3 more
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Iontophoresis of Vidarabine Monophosphate for Herpes Orolabialis
Journal of Infectious Diseases, 1986The cutaneous application of antiviral agents was studied by iontophoresis, a process that increases penetration of most drugs 20- to 60-fold. Twenty-seven subjects with vesicular orolabial herpes were treated one time in a double-blind, placebo-controlled clinical study: nine received vidarabine monophosphate (ara-AMP), nine received acyclovir (ACV ...
L P, Gangarosa +4 more
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