Results 71 to 80 of about 574,511 (219)
Screening Routine Clinical Notes for Epilepsy Surgery Candidates Using Large Language Models
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Epilepsy surgery is severely underutilized despite proven efficacy, with substantial under‐referral of eligible patients in routine clinical practice. This study evaluated the potential role of large language models (LLMs) as decision‐support tools for screening unstructured clinical notes to identify epilepsy surgery candidates and ...
Uriel Fennig +9 more
wiley +1 more source
Journal of Research in Education Sciences, 2014 本研究分別以兩個研究解析不同年資教師於說故事時，手勢表徵的意義類別，以及手勢教學影片對幼兒在詞彙理解的影響。研究一以錄影分析的方法，探討8 位新手教師與8 位資深教師說故事時的手勢行為。結果發現，教師說故事時的手勢以描述故事內容、詞彙的語意提取性質居多；不同年資的教師於表徵故事內容的手勢次數並未有顯著差異的存在；於師生互動的手勢次數，則有顯著的差異存在。研究二分析不同年資教師的教學影片對幼兒詞彙理解的效果研究，以臺東3 所公立幼兒園大班67 位幼兒為對象進行實驗。結果顯示 ...
簡馨瑩 Hsin-Ying Chien +1 more
doaj +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Digital technologies hold promise for transforming healthcare by enhancing personalized treatments and offer valuable opportunities to improve patient care. Here, we evaluated several novel, self‐administered, home‐based, digital endpoints for their association with corresponding conventional standard clinical measures (primary) in ...
Arne Mueller +14 more
wiley +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw +5 more
wiley +1 more source
Design and Experimental Characterization of Developed Human Knee Joint Exoskeleton Prototypes
MachinesThis paper focuses on the experimental testing and characterisation of two designed and constructed prototypes of a human knee joint mechanism. The aim of the mechanical systems, presented as kinematic diagrams and 3D CAD drawings, is to reproduce the ...
Michał Olinski
doaj +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Facioscapulohumeral muscular dystrophy (FSHD) is one of the most debilitating and common muscular dystrophies. Despite its severity, no approved therapy exists for FSHD patients. However, several therapeutic candidates are currently under development, and some have recently entered clinical trials, marking the need for reliable ...
Mustafa Bilal Bayazit +11 more
wiley +1 more source
INFLUENCE OF VIDEO / BIOMECANICAL ANALYSIS ON VALENCES OF MORPH-FUNCTIONAL AND SENSO-MOTOR PARAMETERS OF THE VOLLEYBALL PLAYERS [PDF]
Bulletin of the Transilvania University of Braşov: Series IX Sciences of Human Kinetics, 2018 In this paper, we tried to emphasize the effects that video analysis and biomechanical analysis have on functional, sensory and motor parameters. In the purview pedagogical approach were tested initially and finally, a number of parameters. All tests,
A. PĂCURARU, F. ONESIM
doaj
A 17 Year Old With Developmental Delay Presenting With Increasing Confusion and Imbalance
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Methylmalonic acidemia is an autosomal recessive genetic disorder primarily caused by defects in methylmalonyl‐CoA mutase and cobalamin (vitamin B12) metabolism. These defects disrupt the tricarboxylic acid cycle and oxidative phosphorylation, leading to the abnormal accumulation of metabolic products such as methylmalonic acid, propionic acid,
Wei Zhao, Yingli Zhang, Hongliang Zheng
wiley +1 more source
A Two‐Stage Questionnaire and Actigraphy Screening for iRBD in a Multicenter Retrospective Cohort
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Isolated rapid‐eye‐movement sleep behavior disorder is a prodromal marker of synucleinopathies. However, most cases remain undiagnosed due to the insufficient predictive value of questionnaires and limited access to confirmatory video‐polysomnography. We assessed a two‐stage screening strategy combining a brief questionnaire on rapid‐
Caleb A. Massimi +17 more
wiley +1 more source
Prominent Movement Disorders in RNU2‐2‐Related Spliceosomopathy
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Pediatric movement disorders often overlap with neurodevelopmental diseases, suggesting shared molecular mechanisms. Variants in small nuclear RNA (snRNA) genes encoding spliceosome components have recently been associated with neurodevelopmental disorders, termed “RNUopathies.” We analyzed genome sequencing data from 14 patients with ...
Magdalena Krygier +6 more
wiley +1 more source