Results 101 to 110 of about 12,236 (230)

EEG functional connectivity as a marker of evolution from infantile epileptic spasms syndrome to Lennox–Gastaut syndrome

Epilepsia, EarlyView.
Abstract Objective Timely diagnosis and effective treatment of Lennox–Gastaut syndrome (LGS) improve prognosis and lower health care costs, but the transition from infantile epileptic spasms syndrome (IESS) to LGS is highly variable and insidious. Objective biomarkers are needed to monitor this progression and guide clinical decision‐making. Methods We
Blanca Romero Milà, Virginia B. Liu, Rachel J. Smith, Derek K. Hu, Natalie A. Benneian, Shaun A. Hussain, Maija Steenari, Donald Phillips, David Adams, Clare Skora, Beth A. Lopour, Daniel W. Shrey   +11 more
wiley   +1 more source

Treatment-Resistant Epilepsy and Tuberous Sclerosis Complex: Treatment, Maintenance, and Future Directions

Neuropsychiatric Disease and Treatment, 2023
Avantika Singh,1,* Aristides Hadjinicolaou,1,* Jurriaan M Peters,1 Catherine L Salussolia1,2 1Division of Epilepsy and Neurophysiology, Department of Neurology, Boston Children’s Hospital and Harvard Medical School, Boston, MA, USA; 2F.M.
Singh A, Hadjinicolaou A, Peters JM, Salussolia CL   +3 more
doaj  

Vigabatrin-Induced Seizures in Angelman Syndrome

Pediatric Neurology Briefs, 1998
Four children with Angelman syndrome (AS) showed worsening of seizures after introduction of vigabatrin (VGB), at the University Children’s Hospital, Zurich, Switzerland.
J Gordon Millichap
doaj   +1 more source

Pediatric Investigation Plans for seizure and epilepsy treatments: An analysis since the implementation of the European Pediatric Regulation in 2006

Epilepsia, EarlyView.
Abstract Objective A Pediatric Investigation Plan (PIP) implemented under the European Pediatric Regulation (EC No. 1901/2006) aims to ensure early and systematic evaluation of medicines for children. We analyze PIPs for antiseizure medications (ASMs) submitted to the European Medicines Agency (EMA) since 2006, characterizing their content, focusing on
Valeria Agostini, Stéphane Auvin
wiley   +1 more source

2-Pyrrolidinone and Succinimide as Clinical Screening Biomarkers for GABA-Transaminase Deficiency: Anti-seizure Medications Impact Accurate Diagnosis

Frontiers in Neuroscience, 2019
Broad-scale untargeted biochemical phenotyping is a technology that supplements widely accepted assays, such as organic acid, amino acid, and acylcarnitine analyses typically utilized for the diagnosis of inborn errors of metabolism.
Adam D. Kennedy, Kirk L. Pappan, Taraka Donti, Mauricio R. Delgado, Marwan Shinawi, Toni S. Pearson, Seema R. Lalani, William J. Craigen, V. Reid Sutton, Anne M. Evans, Qin Sun, Lisa T. Emrick, Lisa T. Emrick, Sarah H. Elsea   +13 more
doaj   +1 more source

Selective inhibition of extra-synaptic α5-GABA_A receptors by S44819, a new therapeutic agent [PDF]

, 2017
In the mammalian central nervous system (CNS) GABAA receptors (GABAARs) mediate neuronal inhibition and are important therapeutic targets. GABAARs are composed of 5 subunits, drawn from 19 proteins, underpinning expression of 20-30 GABAAR subtypes.
Adam R. Brown, Adrienn Pálvölgyi, Atack, Balázs Mihalik, Barker, Belelli, Ben G. Gunn, Bergmann, Bolognani, Bonin, Botta, Brown, Brown, Brown, Capogna, Caraiscos, Clarkson, Cobb, Darmani, Delia Belelli, Drexel, Ferenc A. Antoni, Fisahn, Fritschy, Gacsályi, Gacsályi, Hausrat, Herd, Herd, Huerta, István Gacsályi, István Ling, Jeremy J. Lambert, Jones, József Barkóczy, Karayannis, Katalin Pallagi, Keene, Kinnavane, Knust, Lake, Lerma, Ling, Ling, Lori-An Etherington, Lüddens, Maconochie, Martin, Matthew R. Livesey, Mendez, Michael Spedding, Mihalik, Milic, Neves, Olivia Monteiro, Olsen, Peden, Pirker, Prenosil, Péter Varga, Redrobe, Rudolph, Salesse, Salmon, Serwanski, Szabolcs Kertész, Thompson, Ueno, Wang, Wisden, Wlodarczyk, Wu, Zarnowska, Zhang, Zurek   +74 more
core   +2 more sources

Chronic intermittent convection-enhanced delivery of vigabatrin to the bilateral subthalamic nucleus in an acute rat seizure model

, 2023
Devlin MacKeigan, Malte Feja, Manuela Gernert   +2 more
openalex   +1 more source

Seizure recurrence after GLP‐1 receptor agonist initiation in adults with epilepsy

Epilepsia, EarlyView.
Abstract Objective To examine whether initiation of glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) is associated with seizure recurrence and related outcomes in adults with epilepsy and type 2 diabetes. Methods We conducted a retrospective cohort study using de‐identified electronic health records from the TriNetX Research Network (January 2003 ...
Majd A. AbuAlrob, Abdullah Hussein, Rand Abdellatif, Adham Itbaisha, Khaled Zammar, Boulenouar Mesraoua   +5 more
wiley   +1 more source

Succinic semialdehyde dehydrogenase deficiency: Lessons from mice and men [PDF]

, 2009
Succinic semialdehyde dehydrogenase (SSADH) deficiency, a disorder of GABA degradation with subsequent elevations in brain GABA and GHB, is a neurometabolic disorder with intellectual disability, epilepsy, hypotonia, ataxia, sleep disorders, and ...
A Buzzi, A Gropman, A Shao, BM Hogema, C Yalçinkaya, C. Jakobs, CJ Landmark, GL Krauss, GM Chowdhury, I Arnulf, I Knerr, I Knerr, I. Knerr, J. M. Pettiford, K Ergezinger, K Nylen, K. Forester, K. M. Gibson, KM Gibson, LS Stewart, M Gupta, M Gupta, M Qiao, M. A. Cortez, MA Al-Essa, MA Cortez, MT Acosta, O. Carter Snead, P. L. Pearl, PL Pearl, PL Pearl, PL Pearl, PL Pearl, PL Pearl, PL Pearl, R Scherschlicht, RG Peyster, S Vanhatalo, S Ziyeh, SJ Spence, SW Sauer, T Ethofer, T Shinka, V Leuzzi, W Froestl, W. H. Theodore, WH Butler, Y Wu, Y. Wu   +48 more
core   +1 more source

Treatment approaches in posthypoxic myoclonus: A narrative review with expert opinion

Epilepsia, EarlyView.
Abstract Acute posthypoxic myoclonus (PHM) is a neurological complication that typically emerges within 12–48 h following cardiac arrest, often in comatose patients. It can present as generalized, multifocal, or focal myoclonus and has traditionally been associated with poor prognosis.
Marina Romozzi, Federico Tosto, David García‐Azorín, Luigi Francesco Iannone, Catello Vollono, Paolo Calabresi, Juan Luis Alcala‐Zermeno, Michael R. Sperling   +7 more
wiley   +1 more source