Results 101 to 110 of about 15,083 (304)
Vigabatrin's Complicated Journey—To be or Not to Be? [PDF]
Epilepsy Currents, 2009 Visual Fields at School-Age in Children Treated with Vigabatrin in Infancy. Gaily E, Jonsson H, Lappi M. Epilepsia 2009;50(2):206–216. PURPOSE: The use of vigabatrin (VGB) as an antiepileptic drug (AED) has been limited by evidence showing that it causes vigabatrin-attributed visual field loss (VAVFL) in at least 20–40% of patients exposed at school ...
openaire +3 more sources
Neuronal oscillatory imbalances in GNAO1‐related disorders associated with disease severity
Epilepsia, EarlyView.Abstract Objective This study investigates excitatory/inhibitory (E/I) imbalances in GNAO1‐related disorders (GNAO1‐RD), linking neuronal dysfunction to clinical severity using E/I‐sensitive electroencephalography (EEG) analyses. Methods We conducted an observational study involving 12 children with GNAO1‐RD caused by pathogenic variants and 36 age ...
Tongyu Wang +8 more
wiley +1 more source
Epilepsia, EarlyView.Abstract Objective Newer antiseizure medications (ASMs), such as lacosamide and brivaracetam, have promising retention in clinical trials but real‐world data on their effectiveness when used as first or second treatments is missing. Because newer ASMs are often reserved for severe cases, such knowledge accumulates slowly.
André Idegård +2 more
wiley +1 more source
Infantile Spasms Consensus Report
Pediatric Neurology Briefs, 2010 An Infantile Spasms Working Group (ISWG) of 14 pediatric neurologists with expertise in IS participated in a 2-day workshop to discuss 1) the current state of IS management, 2) the evidence for efficacy of ACTH and vigabatrin (VGB), approved in the US in
J Gordon Millichap
doaj +1 more source
Downbeat nystagmus: aetiology and comorbidity in 117 patients [PDF]
, 2008 Objectives: Downbeat nystagmus (DBN) is the most common form of acquired involuntary ocular oscillation overriding fixation. According to previous studies, the cause of DBN is unsolved in up to 44% of cases.
Brandt, Thomas +3 more
core +1 more source
Epilepsia, EarlyView.Abstract Epilepsy affects approximately 1% of the population worldwide, and although medications are effective in the majority of cases, seizures persist in approximately 30% of patients. Despite the effort to develop new antiseizure drugs, the rate of pharmacoresistance in patients has not diminished over the past 3 decades. There is thus a real unmet
Vincent Magloire +9 more
wiley +1 more source
Neuropsychiatric Disease and Treatment, 2008 Luisa RochaPharmacobiology Department, Center for Research and Advanced Studies, Calz, Tenorios, MéxicoAbstract: Experiments using male CD1 mice were carried out to investigate the effects of subchronic (daily administration for 8 days ...
Luisa Rocha
doaj
, 2015 Research in all areas of sciences and humanities has led to the creation of a highly competitive environment which necessitates reporting of ideas, and discoveries at rapid pace.
Siddiqui, Anwar, Wasay, Mohammad
core +1 more source
Epilepsia, EarlyView.Abstract Objective Current preclinical epilepsy drug screening relies on animal models that poorly reflect human neurophysiology, leading to high failure rates in clinical translation. We aimed to establish a human in vitro model using human‐induced pluripotent stem cell (hiPSC)–derived cortical neurons cultured on multielectrode arrays (MEAs), capable
Joshua Nicholls +13 more
wiley +1 more source
Topiramate for the treatment of neonatal seizures and beyond
Epilepsia, EarlyView.Abstract Acute symptomatic neonatal seizures are one of the most common neurological disorders in newborns admitted to neonatal intensive care units and require prompt treatment. Up to 50% of neonatal seizures are refractory to first‐line medications such as phenobarbital (PB), and another 30% fail second‐line therapy.
Wolfgang Löscher, Janet S. Soul
wiley +1 more source