Results 111 to 120 of about 15,083 (304)

PAC‐FOS: A novel translational concordance framework identifies preclinical seizure models with highest predictive validity for clinical focal onset seizures

Epilepsia, EarlyView.
Abstract Objective Central to the development of novel antiseizure medications (ASMs) is testing of antiseizure activity in preclinical models. Although various well‐established models exist, their predictive validity across the spectrum of clinical epilepsies has been less clear.
Lyndsey L. Anderson, Kristopher M. Kahlig, Melissa L. Barker‐Haliski, Lillian G. Matthews, Hamish D. Toop, Brian Hannigan, Jacqueline French, H. Steve White, Marcio Souza, Steven Petrou   +9 more
wiley   +1 more source

Treatment-Resistant Epilepsy and Tuberous Sclerosis Complex: Treatment, Maintenance, and Future Directions

Neuropsychiatric Disease and Treatment, 2023
Avantika Singh,1,* Aristides Hadjinicolaou,1,* Jurriaan M Peters,1 Catherine L Salussolia1,2 1Division of Epilepsy and Neurophysiology, Department of Neurology, Boston Children’s Hospital and Harvard Medical School, Boston, MA, USA; 2F.M.
Singh A, Hadjinicolaou A, Peters JM, Salussolia CL   +3 more
doaj  

Vigabatrin-Induced Seizures in Angelman Syndrome

Pediatric Neurology Briefs, 1998
Four children with Angelman syndrome (AS) showed worsening of seizures after introduction of vigabatrin (VGB), at the University Children’s Hospital, Zurich, Switzerland.
J Gordon Millichap
doaj   +1 more source

Neue Entwicklungen in der Pharmakotherapie der Kokainabhängigkeit [PDF]

, 2018
Zusammenfassung: Es zeichnen sich neue medikamentöse Behandlungsmöglichkeiten der Kokainabhängigkeit ab. So gelang es erstmals mit Disulfiram in einer randomisierten, kontrollierten Studie, den Kokainkonsum signifikant zu reduzieren.
Dürsteler-MacFarland, K., Wiesbeck, G.
core  

Midbrain dopamine neurons sustain inhibitory transmission using plasma membrane uptake of GABA, not synthesis [PDF]

, 2014
Synaptic transmission between midbrain dopamine neurons and target neurons in the striatum is essential for the selection and reinforcement of movements. Recent evidence indicates that nigrostriatal dopamine neurons inhibit striatal projection neurons by
Gu, Chenghua, Oh, Won-Jong, Sabatini, Bernardo L, Tritsch, Nicolas X   +3 more
core   +1 more source

Long‐read sequencing of recurrent FGF12 duplications in epilepsy: Insights into structural mechanisms and aberrant isoforms

Epilepsia, EarlyView.
Abstract Objective Fibroblast growth factor 12 (FGF12), a member of the fibroblast homologous factor family, plays a key role in the modulation of voltage‐gated sodium (Nav) channels. Pathogenic variants in the FGF12 gene leading to a gain‐of‐function mechanism and partial duplication encompassing the FGF12 gene leading to a loss‐of‐function mechanism ...
Jade Fauqueux, Laurence Chaton, Pierre Cleuziou, Anne‐Sophie Diependaële, Nathalie Bach, Nicolas Gruchy, Marion Gerard, Jean‐Pascal Meneboo, Céline Villenet, Martin Figeac, Emilie Ait‐Yahya, Caroline Thuillier, Elise Boudry, Adeline Trauffler, Sylvie Nguyen‐The‐Tich, Simon Boussion, Roseline Caumes, Jamal Ghoumid, Thomas Smol   +18 more
wiley   +1 more source

2-Pyrrolidinone and Succinimide as Clinical Screening Biomarkers for GABA-Transaminase Deficiency: Anti-seizure Medications Impact Accurate Diagnosis

Frontiers in Neuroscience, 2019
Broad-scale untargeted biochemical phenotyping is a technology that supplements widely accepted assays, such as organic acid, amino acid, and acylcarnitine analyses typically utilized for the diagnosis of inborn errors of metabolism.
Adam D. Kennedy, Kirk L. Pappan, Taraka Donti, Mauricio R. Delgado, Marwan Shinawi, Toni S. Pearson, Seema R. Lalani, William J. Craigen, V. Reid Sutton, Anne M. Evans, Qin Sun, Lisa T. Emrick, Lisa T. Emrick, Sarah H. Elsea   +13 more
doaj   +1 more source

A 47-Year Old Female with Muscular Rigidity, New-Onset Diabetes and Hypothyroidism [PDF]

, 2013
Background This case highlights a rare but devastating neurologic condition, Stiff Person Syndrome (SPS). While symptoms of muscular rigidity andspasms areassocia ted with numerous neuromuscular conditions, the association between SPS, autoimmune ...
Valentino, MD, PhD, Michael A.
core   +2 more sources

Vigabatrin retinal toxicity in children with infantile spasms

Neurology, 2014
Objectives: To determine time to vigabatrin (VGB, Sabril; Lundbeck, Deerfield, IL) induced retinal damage in children with infantile spasms (IS) and to identify risk factors for VGB-induced retinal damage (VGB-RD).
C. Westall, T. Wright, F. Cortese, Ananthavalli Kumarappah, Msc O Carter, S. Iii, J. Buncic   +6 more
semanticscholar   +1 more source

Vigabatrin dosing during haemodialysis

Seizure, 1996
The antiepileptic drug vigabatrin has shown efficacy in the treatment of patients with refractory epilepsy. Unlike many other antiepileptics it is not bound to plasma protein and mainly eliminated by the kidney. Although the therapeutic and toxic serum concentration range is not clearly defined and efficacy and toxicity are not closely correlated with ...
Rudolf Ritz, Walter E. Haefeli, Daniella Bachmann, Nils Wad   +3 more
openaire   +3 more sources