Results 201 to 210 of about 12,236 (230)
Ethylmalonic encephalopathy caused by biallelic truncating variants in ETHE1: A case report. [PDF]
SAGE Open Med Case RepRuiz-Martinez DA +5 more
europepmc +1 more source
Vigabatrin-associated brain magnetic resonance imaging abnormalities and clinical symptoms in infants with tuberous sclerosis complex. [PDF]
EpilepsiaStevering C +33 more
europepmc +1 more source
Lodder-Merla Syndrome, a Multisystemic Disorder: Perioperative Anesthetic Management of an Infant. [PDF]
Acta Med AcadAstyrakaki E +4 more
europepmc +1 more source
Breath-holding spells comorbidity with epileptic seizures in children: VEEG and clinical outcomes. [PDF]
Medicine (Baltimore)Chen B, Fang H, Kuang X, Ning Z, Wang L.
europepmc +1 more source
Editorial: The effects of emerging and commonly used medications on the developing brain. [PDF]
Front PediatrBurnsed J, Chavez-Valdez R.
europepmc +1 more source
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Epilepsia, 1994
Summary: The discovery of γ‐aminobutyric acid (GABA) as the first major inhibitory neurotransmitter and a program exploring the use of enzyme inhibition as a therapeutic tool provided the basis for the conception of vigabatrin (VGB, Sabril). This molecule, an analogue of GABA, has a highly specific activity as an enzyme‐activated irreversible ...
J P, Mumford, D J, Cannon
+6 more sources
Summary: The discovery of γ‐aminobutyric acid (GABA) as the first major inhibitory neurotransmitter and a program exploring the use of enzyme inhibition as a therapeutic tool provided the basis for the conception of vigabatrin (VGB, Sabril). This molecule, an analogue of GABA, has a highly specific activity as an enzyme‐activated irreversible ...
J P, Mumford, D J, Cannon
+6 more sources
Seminars in Pediatric Neurology, 1997
Vigabatrin is a structural analogue of gamma amino butyric acid (GABA), which binds irreversibly to GABA-transaminase causing increased brain levels of GABA. It is an important advance in the medical management of children with epilepsy. It appears to be particularly effective in the treatment of infantile spasms, especially when caused by tuberous ...
W D, Shields, R, Sankar
+5 more sources
Vigabatrin is a structural analogue of gamma amino butyric acid (GABA), which binds irreversibly to GABA-transaminase causing increased brain levels of GABA. It is an important advance in the medical management of children with epilepsy. It appears to be particularly effective in the treatment of infantile spasms, especially when caused by tuberous ...
W D, Shields, R, Sankar
+5 more sources
Clinical Pharmacokinetics, 1992
Vigabatrin is a structural analogue of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA). It is supplied as a racemic mixture, with the S(+) enantiomer possessing pharmacological activity. [R,S]-Vigabatrin plasma concentrations can be estimated using high-performance liquid chromatographic methods. Only gas chromatography-mass spectrometry
E, Rey, G, Pons, G, Olive
openaire +4 more sources
Vigabatrin is a structural analogue of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA). It is supplied as a racemic mixture, with the S(+) enantiomer possessing pharmacological activity. [R,S]-Vigabatrin plasma concentrations can be estimated using high-performance liquid chromatographic methods. Only gas chromatography-mass spectrometry
E, Rey, G, Pons, G, Olive
openaire +4 more sources