Results 231 to 240 of about 15,406 (277)
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Epilepsia, 1994
Summary: The discovery of γ‐aminobutyric acid (GABA) as the first major inhibitory neurotransmitter and a program exploring the use of enzyme inhibition as a therapeutic tool provided the basis for the conception of vigabatrin (VGB, Sabril). This molecule, an analogue of GABA, has a highly specific activity as an enzyme‐activated irreversible ...
J P, Mumford, D J, Cannon
+6 more sources
Summary: The discovery of γ‐aminobutyric acid (GABA) as the first major inhibitory neurotransmitter and a program exploring the use of enzyme inhibition as a therapeutic tool provided the basis for the conception of vigabatrin (VGB, Sabril). This molecule, an analogue of GABA, has a highly specific activity as an enzyme‐activated irreversible ...
J P, Mumford, D J, Cannon
+6 more sources
Journal of Child Neurology, 2022
Objective: In a randomized trial, we aimed to evaluate the efficacy of cosyntropin injectable suspension, 1 mg/mL, compared to vigabatrin for infantile spasms syndrome.
K. Knupp +18 more
semanticscholar +1 more source
Objective: In a randomized trial, we aimed to evaluate the efficacy of cosyntropin injectable suspension, 1 mg/mL, compared to vigabatrin for infantile spasms syndrome.
K. Knupp +18 more
semanticscholar +1 more source
Risk of vigabatrin‐associated brain abnormalities on MRI: A retrospective and controlled study
Epilepsia, 2021Vigabatrin (VGB) is the first‐line treatment for infantile spasms (IS). Previous studies have shown that VGB exposure may cause vigabatrin‐associated brain abnormalities on magnetic resonance imaging (MRI) (VABAM).
Yong Xu +13 more
semanticscholar +1 more source
Visual field defects after vigabatrin treatment during infancy: retrospective population‐based study
Developmental Medicine & Child Neurology, 2021To investigate the prevalence of vigabatrin‐attributed visual field defect (VAVFD) in infantile spasms and the utility of optical coherence tomography (OCT) in detecting vigabatrin‐related damage.
Henna Jonsson +4 more
semanticscholar +1 more source
Clinical Utility of Electroretinograms for Evaluating Vigabatrin Toxicity in Children.
Journal of pediatric ophthalmology and strabismus, 2021PURPOSE To determine changes in the clinical treatment of pediatric patients taking vigabatrin for seizure control in response to results of electroretinogram (ERG) performed for retinal toxicity screening.
Anne Strong +6 more
semanticscholar +1 more source
Seminars in Pediatric Neurology, 1997
Vigabatrin is a structural analogue of gamma amino butyric acid (GABA), which binds irreversibly to GABA-transaminase causing increased brain levels of GABA. It is an important advance in the medical management of children with epilepsy. It appears to be particularly effective in the treatment of infantile spasms, especially when caused by tuberous ...
W D, Shields, R, Sankar
openaire +3 more sources
Vigabatrin is a structural analogue of gamma amino butyric acid (GABA), which binds irreversibly to GABA-transaminase causing increased brain levels of GABA. It is an important advance in the medical management of children with epilepsy. It appears to be particularly effective in the treatment of infantile spasms, especially when caused by tuberous ...
W D, Shields, R, Sankar
openaire +3 more sources
Epilepsia, 2020
Vigabatrin (VGB), adrenocorticotropic hormone (ACTH), and prednisone are first‐line treatments for infantile spasms (IS). A recent study reported benefits from the use of combination VGB and hormonal therapy over hormonal treatment alone in IS.
S. Bhalla, K. Skjei
semanticscholar +1 more source
Vigabatrin (VGB), adrenocorticotropic hormone (ACTH), and prednisone are first‐line treatments for infantile spasms (IS). A recent study reported benefits from the use of combination VGB and hormonal therapy over hormonal treatment alone in IS.
S. Bhalla, K. Skjei
semanticscholar +1 more source
Clinical Pharmacokinetics, 1992
Vigabatrin is a structural analogue of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA). It is supplied as a racemic mixture, with the S(+) enantiomer possessing pharmacological activity. [R,S]-Vigabatrin plasma concentrations can be estimated using high-performance liquid chromatographic methods. Only gas chromatography-mass spectrometry
E, Rey, G, Pons, G, Olive
openaire +4 more sources
Vigabatrin is a structural analogue of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA). It is supplied as a racemic mixture, with the S(+) enantiomer possessing pharmacological activity. [R,S]-Vigabatrin plasma concentrations can be estimated using high-performance liquid chromatographic methods. Only gas chromatography-mass spectrometry
E, Rey, G, Pons, G, Olive
openaire +4 more sources
Epilepsia, 1995
Summary: γ‐Aminobutyric acid (GABA) was first proposed as a putative inhibitory neurotransmitter by Elliot and van Gelder in 1958. Since then, numerous efforts have been made to find ways to increase GABA at its receptor sites, based on the findings that decreased GABA results in convulsions in animals and that agents enhancing GABA‐mediated functions
openaire +3 more sources
Summary: γ‐Aminobutyric acid (GABA) was first proposed as a putative inhibitory neurotransmitter by Elliot and van Gelder in 1958. Since then, numerous efforts have been made to find ways to increase GABA at its receptor sites, based on the findings that decreased GABA results in convulsions in animals and that agents enhancing GABA‐mediated functions
openaire +3 more sources