Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
OENO One, 1999 The influence of grapevine water status on vine physiological mecanisms and vigour, as well as on berry ripening and wine characteristics, was studied during the summer of 1997 in the Nemea vine growing area (Peloponnesus, Greece).
Stefanos Koundouras +3 more
doaj +1 more source
THE INVESTIGATION OF CROP WEEDINESS IN THE CROP ROTATION OF ORGANIC FARMING SYSTEM [PDF]
, 2008 Field experiments were conducted during the period of 2004 – 2006 at the Research and Study Farm „Vecauce”. The aim of the investigation was to establish the weediness’ dynamics of crops in a six-field crop rotation of an organic farming system.
Ausmane , M., Gaile, Z., Melngalvis, I.
core
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
An evaluation of a psychosocial stress and coping model in the police work context
SA Journal of Industrial Psychology, 2010 Orientation: Stress is a social reality which does not exist in isolation, but in many social situations, especially work-related environments. Police officers in particular suffer from highly negative stress related outcomes.
Gerrit J. Louw, Adriaan Viviers
doaj +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
An evaluation of osmotic pre-sowing seed treatments as a potential method for improving the germination performance of Pinus radiata D. Don seeds : a thesis presented in partial fulfilment of the requirements for the degree of Master of Agricultural Science in Seed Technology at Massey University [PDF]
, 1992 This study was conducted lo characterise optimum conditions for osmotic pre-sowing treatment as an effective means of improving the germination and/or emergence performance of Pinus radiata from different seed grades.
Kusmintardjo
core
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Model assisted phenotyping of processes involved in rice response to drought: case study of a tropical japonica population during vegetative phase : [Abstract, P 7.15] [PDF]
, 2009 Tropical japonica rice is frequently exposed to drought in upland ecosystems. Its drought tolerance is poor compared to other crops but the group has great genetic, in part unexploited diversity in adaptations.
Dinkguhn, M. +7 more
core
Testing of Hybrid Vigour for Sex Phenology in Cucumber (Cucumis sativus L.) [PDF]
, 2019 Prashant R. Naik +3 more
openalex +1 more source