Results 61 to 70 of about 40,776 (295)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Use of tetrazolium (TTC), Germ's and greenhouse plant emergences methods for testing seed vigour of selected ornamental plant species

Acta Agrobotanica, 2013
In the years 1996-1997 the experiments were carried out on methods to investigate seed vigour of tassel flower (Amaranthus caudatus L.), sand pink (Dianthus chinensis L.), babies' breath (Gypsophila elegans M.B.), sweet pea (Lathyrus odorathus L ...
Roman Hołubowicz, Xian Wang, Wiesław Siutaj   +2 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Dopamine promotes instrumental motivation, but reduces reward-related vigour

eLife, 2020
We can be motivated when reward depends on performance, or merely by the prospect of a guaranteed reward. Performance-dependent (contingent) reward is instrumental, relying on an internal action-outcome model, whereas motivation by guaranteed reward may ...
John P Grogan, Timothy R Sandhu, Michele T Hu, Sanjay G Manohar   +3 more
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Sex Differences in High-Cost Users of Healthcare for Atrial Fibrillation

CJC Open
Background: Healthcare resource use for atrial fibrillation (AF) is high, but it may not be equivalent across all patients. We examined whether sex differences exist for AF high-cost users (HCUs), who account for the top 10% of total acute care costs ...
Roopinder K. Sandhu, MD, MPH, Hena Qureshi, MSc, Heather Halperin, BSc, Douglas C. Dover, PhD, Nathan Klassen, MA, Nathaniel M. Hawkins, MD, Jason G. Andrade, MD, Padma Kaul, PhD   +7 more
doaj   +1 more source

Total and Cause-Specific Mortality After Percutaneous Coronary Intervention: Observations From the Alberta Provincial Project for Outcome Assessment in Coronary Heart Disease Registry

CJC Open, 2019
Background: Patients undergoing percutaneous coronary intervention (PCI) are increasingly older and have a higher comorbidity burden. This study evaluated trends in 30-day, 1-year, and 2-year total and cause-specific mortality using a large, contemporary
Dat T. Tran, PhD, Walid Barake, MD, Diane Galbraith, BN, MSc, Colleen Norris, PhD, Merril L. Knudtson, MD, FRCPC, Padma Kaul, PhD, Finlay A. McAlister, MD, PhD, Roopinder K. Sandhu, MD, MPH   +7 more
doaj   +1 more source

Hybrid Vigour? Genes, Genomics, and History [PDF]

Genomics, Society and Policy, 2008
Is the gene 'special' for historians? What effects, if any, has the notion of the 'gene' had on our understanding of history? Certainly, there is a widespread public and professional perception that genetics and history are or should be in dialogue with each other in some way.
openaire   +2 more sources

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Parliamentary roles and discourses of legitimacy. A lexical analysis of a French parliamentary debate on the relationships between judicial and politics

, 2010
Co-organisation du Colloque : Vigour Cécile, de Galembert Claire et Rozenberg ...
Vigour, Cécile
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