Results 101 to 110 of about 6,192 (194)

Pharmacokinetic and pharmacodynamic interaction of vildagliptin and voglibose in Japanese patients with type 2 diabetes

, 2013
Objective: To assess the extent of pharmacokinetic and pharmacodynamic interaction between vildagliptin, a potent and selective inhibitor of dipeptidyl peptidase IV (DPP-4) enzyme, and voglibose, an α-glucosidase inhibitor widely prescribed in Japan ...
Kenichi, Furihata, Nozaki, Sachiko, Saji, Takami, Kulmatycki, Kenneth, He, Yan-Ling, Yamaguchi, Masayuki, Sekiguchi, Kaneo   +6 more
core  

Potential effect of metformin and vildagliptin against isoniazid induced hepatotoxicity in Wistar albino rats

Background: Metformin and vildagliptin both are anti-diabetic agent and they play an important role in diabetic patients as they reduce blood glucose levels.
Kannan A., Rohith, E., Nithyasri, J., Lokesh, M., Narmatha, T., Jeeva, S., Shoba   +5 more
core   +2 more sources

Bioequivalence and Food Effect Assessment for Vildagliptin/Metformin Fixed-dose Combination Tablets Relative to Free Combination of Vildagliptin and Metformin in Japanese Healthy Subjects

, 2015
Objective: To assess the bioequivalence of vildagliptin/metformin fixed-dose combination (FDC) tablets (50/250 mg and 50/500 mg) to free combinations of vildagliptin and metformin and the effect of food on the pharmacokinetics (PK) of vildagliptin and ...
Nozaki, Sachiko, Suzuki, Hikoe, Kulmatycki, Kenneth, Salunke, Atish Azad, He, Yan-Ling, Zhou, Wei, Chitnis, Shripad   +6 more
core  

Translating science into clinical practice: focus on vildagliptin in combination with metformin.

, 2009
Vildagliptin is a potent and selective oral dipeptidyl peptidase-4 inhibitor that improves glycaemic control in patients with type 2 diabetes mellitus (T2DM) by increasing both alpha- and beta-cell responsiveness to glucose.
Barnett, Anthony, A. H. Barnett
core   +1 more source

Clinical evidence and mechanistic basis for vildagliptin's effect in combination with insulin

Vascular Health and Risk Management, 2013
Anja Schweizer,1 James E Foley,2 Wolfgang Kothny,2 Bo Ahrén31Novartis Pharma AG, Basel, Switzerland; 2Novartis Pharmaceuticals Corporation, East Hanover, NJ, USA; 3Department of Clinical Sciences, Lund University, Lund, SwedenAbstract: Due to ...
Schweizer A, Foley JE, Kothny W, Ahrén B   +3 more
doaj  

A comparative study on vildagliptin brand and its generic equivalents using dissolution test as quality control measure tool

Scientific Reports
Market drugs including brand or generic with poor quality, don’t meet the acceptable standard guidelines. Vildagliptin is an important antidiabetic drugs used in monotherapy or in combinations protocols for treatment of diabetes mellites.
Ghadah H. Altoum, Fouza K. AL-Enazi, Mubarl M. Abudahash, Reem A. AL-Fadhli, Naif Alenzi   +4 more
doaj   +1 more source

Phosphatidylinositol-3-kinase/Protein Kinase B (PI3K/AKT) and Nucleotide-Binding Oligomerization Domain-like Receptor Family Pyrin Domain Containing 3 (NLRP3) Inflammasome Modulation Underlies the Neuroprotective Effects of Vildagliptin in a Rotenone-Induced Mouse Model of Parkinson's Disease. [PDF]

ACS Pharmacol Transl Sci
Patel D, Soni R, Bhogal I, Roy S, Shah J.   +4 more
europepmc   +1 more source

Safety and Tolerability of Vildagliptin 100 mg Sustained-Release Formulation in Type 2 Diabetes Mellitus: Results From a Prospective, Multicenter, Single-Arm, Post-marketing Surveillance Study. [PDF]

Cureus
Soni P, Sonawane A, Gaidhani S, Baxi N, Malhotra D, Acharya S.   +5 more
europepmc   +1 more source

Docosahexaenoic acid is comparable to vildagliptin in improving hyperglycemia and pancreatic insulin signaling of diabetic rats via SIRT1/Akt/PI3K pathway. [PDF]

Sci Rep
Abo-Saif MA, Werida RH, Mohamed SA, Khedr NF.   +3 more
europepmc   +1 more source

Association Between Dipeptidyl Peptidase-4 Inhibitor Use and Acute Kidney Injury in Patients With Diabetes Mellitus: A Disproportionality Analysis Based on the FAERS. [PDF]

In Vivo
Ohyama K, Takahashi T, Akiyama S, Hori Y.   +3 more
europepmc   +1 more source