Vildagliptin promotes diabetic foot ulcer healing through autophagy modulation
Diabetology & Metabolic SyndromeThe study aimed to investigate the molecular mechanisms underlying the effects of Vildagliptin on the healing of diabetic foot ulcers (DFUs). The research compared patients who received 12 weeks of Vildagliptin treatment to those who did not.
Erik Biros +2 more
doaj +2 more sources
Integrative In Silico Profiling of Major Phytochemicals From a Sclerocarya birrea-Nauclea latifolia-Piper longum Mixture: Docking, Molecular Dynamics, ADMET, and Ligand-Based Target Prediction on Shared Pathways in Type 2 Diabetes Mellitus and Alzheimer's Disease. [PDF]
ChemistryOpenWhich major phytochemical from the Sclerocarya birrea–Nauclea latifolia–Piper longum mixture engages shared targets across the T2DM–AD axis? Integrated docking, triplicate 100‐ns molecular dynamics, post‐MD MM‐GBSA, and ADMET/target prediction prioritize QR‐PME, which forms stable GSK3β and TACE complexes with binding energy estimates comparable to ...
Tientcheu JPD, İstifli ES.
europepmc +2 more sources
Combined saline and vildagliptin induced M2 macrophage polarization in hepatic injury induced by acute kidney injury [PDF]
PeerJ, 2023 Acute kidney injury (AKI) is a prevalent medical condition accompanied by mutual affection of other organs, including the liver resulting in complicated multiorgan malfunction.
Shaimaa N. Amin +5 more
doaj +2 more sources
Journal of Diabetology, 2023 Background: Branded generics offer comparable therapeutic benefits at a lower cost, making them essential in healthcare systems worldwide. Vildagliptin, a widely prescribed antidiabetic medication, is available in various branded generic forms.
Shambo S Samajdar +5 more
doaj +1 more source
Journal of Diabetes Investigation, 2019 A 69‐year‐old man started taking the dipeptidyl peptidase‐4 inhibitor, vildagliptin. One week later, C‐reactive protein and plasma immunoglobulin E levels were markedly elevated, and the vildagliptin was stopped.
Takatoshi Anno +6 more
doaj +1 more source
Comparison of Vildagliptin-Metformin and Glimepiride-Metformin Treatments in Type 2 Diabetic Patients [PDF]
Diabetes & Metabolism Journal, 2011 BackgroundThe present study investigated the efficacy and safety of vildagliptin-metformin treatment compared to those of glimepiride-metformin treatment for type 2 diabetes.MethodsIn a randomized, open-label, comparative study, 106 patients with type 2 ...
Hyun Jeong Jeon, Tae Keun Oh
doaj +1 more source
The Influence of Excipients’ Chemical Nature on the Degradation of Metformin and Vildagliptin [PDF]
Kemija u IndustrijiThe influence of the chemical nature of excipients (magnesium stearate, povidone, microcrystalline cellulose, lactose, crospovidone, and talc) on the degradation of metformin and vildagliptin was tested by forced degradation, using acid hydrolysis, base ...
Amra Demirović +2 more
doaj +1 more source
International Journal of Endocrinology, 2015 The study explored the utility of four-point preprandial glucose self-monitoring to calculate several indices of glycemic control and variability in a study adding the DPP-4 inhibitor vildagliptin to ongoing insulin therapy.
Andrea Tura +5 more
doaj +1 more source
Two Cases of Bullous Pemphigoid Induced by Vildagliptin
Endocrinology Research and Practice, 2018 Purpose: Bullous pemphigoid is an autoimmune blistering disorder that commonly develops in elderly subjects who are prone to an increased risk of mortality and morbidity.
Aslı ÜNAL DOĞRUK +6 more
doaj +1 more source
A Prospective Observational Study to Compare the Efficacy and Adverse Effects of Glimepiride and Vildagliptin Added to Metformin in Type 2 Diabetes Mellitus [PDF]
Journal of Clinical and Diagnostic Research, 2019 Introduction: In order to prevent the specific diabetes mellitus related macrovascular and microvascular complications, guidelines by American Diabetes Association recommend a reasonable glycosylated haemoglobin goal for non-pregnant adults to be less ...
Biswanath Sharma Sarkar +3 more
doaj +1 more source