Results 71 to 80 of about 9,912 (208)

Postprandial Hypotension—Methods for the Evaluation and Management

Geriatrics &Gerontology International, Volume 26, Issue 4, April 2026.
Postprandial hypotension (PPH) is highly prevalent in older patients; however, its diagnosis remains challenging due to the absence of a consensus guideline for diagnostic criteria. Lifestyle modification is the first‐line management, taking into account the pathophysiology underlying PPH and the coexisting conditions of orthostatic hypotension and ...
Joji Ishikawa, Ayumi Toba, Shutaro Futami, Kazumasa Harada   +3 more
wiley   +1 more source

Safety of anagliptin/metformin combination tablets evaluated by non‐inferiority between pre‐ and post‐serum lactic acid levels in Japanese patients with type 2 diabetes and moderate renal impairment (AMELIO STUDY)

Journal of Diabetes Investigation, Volume 17, Issue 4, Page 636-648, April 2026.
To investigate the safety of anagliptin/metformin combination tablets in Japanese patients of type 2 diabetes with moderate renal impairment. This study demonstrates that the fixed‐dose combination of anagliptin and metformin can be used safely in patients with type 2 diabetes complicated by moderate renal dysfunction.
Hiroshi Kajio, Ryotaro Bouchi, Mitsuhisa Komatsu, Masanori Yamazaki, Daisuke Takarabe, Masahide Okamoto, Takahisa Tanaka, Toru Kitazawa, Hisayuki Katsuyama, Yasumichi Mori, Mitsuhiko Noda   +10 more
wiley   +1 more source

Patient preference and tolerability of a DPP-4 inhibitor a GLP-1 analog in patients with type 2 diabetes mellitus inadequately controlled with metformin: a 24-week, randomized, multicenter, crossover study

Therapeutic Advances in Endocrinology and Metabolism, 2015
Objective: The present study aimed to assess the patient preference and tolerability of oral dipeptidyl peptidase-4 inhibitor (vildagliptin) versus injectable glucagon-like peptide-1 analog (liraglutide) in patients with type 2 diabetes mellitus ...
Jörg Lüdemann, Eva D. Dütting, Markus Dworak   +2 more
doaj   +1 more source

Effect of exenatide on splanchnic and peripheral glucose metabolism in type 2 diabetic subjects [PDF]

, 2011
OBJECTIVE: Our objective was to examine the mechanisms via which exenatide attenuates postprandial hyperglycemia in type 2 diabetes mellitus (T2DM). STUDY DESIGN: Seventeen T2DM patients (44 yr; seven females, 10 males; body mass index = 33.6 kg/m(2 ...
Cersosimo, Eugenio, Cervera, Antonio, Defronzo, Ralph A., Fernandez, Marianella, Gastaldelli, Amalia, Musi, Nicholas, Petz, Roberta, Sriwijilkamol, Apiradee, Triplitt, Curtis, Wajcberg, Estela, Zuo, Pengou   +10 more
core   +1 more source

Pathology and glia type specific changes of the DPP4 activity in the spinal cord contributes to the development and maintenance of hyperalgesia and shapes opioid signalling in chronic pain states [PDF]

, 2017
Altered pain sensations such as hyperalgesia and allodynia are characteristic features of various chronic pain states, and remain difficult to treat.
Alpár, Alán, Balázsa, Tamás, Barta, Benjamin, Bölcskei, Kata, Fekete, Csaba, Gerber, Gábor, Helyes, Zsuzsanna, Király, Kornél, Kozsurek, Márk, Lukácsi, Erika, Pap, Károly, Puskár, Zita, Szabon, Judit, Tekus, Valeria, Tóth, Zsuzsanna   +14 more
core  

Do incretins improve endothelial function? [PDF]

, 2014
An impaired endothelial function has been recognized in the early stage of atherosclerosis, and is a major factor affecting the future development of cardiovascular events.
Jun-ichi Oyama, Koichi Node, Yukihito Higashi   +2 more
core   +1 more source

Comparing SGLT2i and Other Oral Antidiabetic Drugs as Dual Therapy Add‐On to Metformin in Type 2 Diabetes: A Systematic Review and Meta‐Analysis

Endocrinology, Diabetes &Metabolism, Volume 9, Issue 2, March 2026.
This systematic literature review and meta‐analysis compared sodium‐glucose cotransporter‐2 inhibitors (SGLT‐2is) against other metformin‐containing oral dual‐therapies (ODTs) in type 2 diabetes mellitus. SGLT‐2i plus metformin exhibited overall comparable efficacy and safety, with a lower risk of hypoglycaemia and greater weight reduction than other ...
Yuhang Ma, Yi Lin, Xiaoying Ding, Yongde Peng   +3 more
wiley   +1 more source

Vildagliptin: a new oral treatment for type 2 diabetes mellitus

Vascular Health and Risk Management, 2008
Chantal Mathieu, Evy DegrandeDepartment of Endocrinology, Katholieke Universiteit Leuven, Leuven, BelgiumAbstract: Vildagliptin is a new oral antidiabetic agent that enhances pancreatic islet cell responsiveness to glucose.
Chantal Mathieu, Evy Degrande
doaj  

Crystal structure of Porphyromonas gingivalis dipeptidyl peptidase 4 and structure-activity relationships based on inhibitor profiling [PDF]

, 2017
The Gram-negative anaerobe Porphyromonas gingivalis is associated with chronic periodontitis. Clinical isolates of P. gingivalis strains with high dipeptidyl peptidase 4 (DPP4) expression also had a high capacity for biofilm formation and were more ...
Augustyns, Koen, De Meester, Ingrid, De Winter, Hans, Fülöp, Vilmos, Lambeir, Anne-Marie, Landuyt, Bart, Luyten, Walter, Rea, Dean, Schoofs, Liliane, Van Der Veken, Pieter, Van Elzen, Roos, Van Goethem, Sebastiaan   +11 more
core   +1 more source

The Level and Clinical Significance of B Lymphocytes and Immune Molecules (IL‐4, IL‐10, BAFF, and IgD) in Psoriasis

Immunity, Inflammation and Disease, Volume 14, Issue 3, March 2026.
ABSTRACT Background Psoriasis is an immune‐mediated chronic skin disease. Despite the low proportion of B cells in human blood, they play an important role in regulating the pathogenesis of psoriasis. Therefore, we investigated the role and clinical significance of B cells in psoriasis by conducting experiments.
Boheng Wu, Ru Qin, Lichuan Lai, Shangyang Li, Ruilan Lin, Yunlong Zhang, Yao Guan, Yulin Yuan   +7 more
wiley   +1 more source