Results 191 to 200 of about 120,449 (305)

Clonal Complexity Defines Distinct Tumor‐Intrinsic Biology and Prognosis in Diffuse Large B‐Cell Lymphoma

open access: yesCancer Medicine, Volume 15, Issue 2, February 2026.
High intratumor heterogeneity in DLBCL is associated with reduced event‐free survival, particularly in the ABC subtype. Tumors with high clonal composition exhibit more aggressive biological behavior compared to monoclonal tumors in the ABC subtype of DLBCL.
Takahiro Haeno   +8 more
wiley   +1 more source

Langerhans Cell Histiocytosis Presenting With Diabetes Insipidus in a 2 Years Old Child: A Case Report

open access: yesClinical Case Reports, Volume 14, Issue 2, February 2026.
ABSTRACT This case report highlights that Langerhans cell histiocytosis should be suspected in the differential diagnosis for children who exhibit failure to thrive, diabetes insipidus, and skin lesions. Early recognition and timely management are crucial for preventing irreversible hypothalamic–pituitary damage and improving outcomes.
Kidus Geabriel Yohannes   +3 more
wiley   +1 more source

DNTTIP1 drives leukaemogenesis through MiDAC‐mediated epigenetic silencing of BMF

open access: yesClinical and Translational Medicine, Volume 16, Issue 2, February 2026.
DNTTIP1 cooperates with SP1 to recruit HDAC1/2, leading to BMF silencing and reduced competitive binding of BMF to BCL2.This suppresses autophagy and apoptosis, promoting leukaemic cell survival. Targeting the DNTTIP1‐HDAC1/2‐BMF axis reactivates BMF and induces anti‐leukaemic effects.
Ruolin Xiu   +12 more
wiley   +1 more source

Preclinical drug screen identifies WEE1 inhibitor and vinca alkaloid as a combination treatment concept for Li-Fraumeni syndrome medulloblastoma. [PDF]

open access: yesiScience
Kolodziejczak AS   +24 more
europepmc   +1 more source

New cell lines expanding the diversity of Ewing sarcoma models

open access: yesInternational Journal of Cancer, Volume 158, Issue 3, Page 642-655, 1 February 2026.
What's new? A chromosomal translocation between the EWSR1 and ETS genes is the key oncogenic driver in Ewing sarcoma. EWSR1::FLI1, the most frequent fusion, is subdivided into different fusion types with unclear prognostic relevance. Here, the authors describe the establishment and characterization of four new, intrinsically immortal, patient‐derived ...
Maximilian Kerkhoff   +13 more
wiley   +1 more source

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