Vinpocetine inhibits VSMCs chemokinesis.
A: Representative chemokinesis of VSMCs among the different groups. Wound closure was induced by normal (5 mM) or higher glucose (10, 25 mM) at 0, 24 and 48 h post-wounding in the absence or presence of vinpocetine (15, 30 and 50 µM).
Baoxin Liu (167406) +9 more
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[Cerebral uptake and metabolism of (11C) Vinpocetine in monkeys: PET studies]
Vinpocetine, a vinca alkaloid, is a therapeutic agent widely used in the treatment of acute and chronic stroke patients. To explore the uptake and distribution of vinpocetine in the primate brain, vinpocetine was labelled with 11C and positron emission ...
Gulyás, B +6 more
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Vinpocetine increases the microsporicidal effect of albendazole on Encephalitozoon intestinalis
Microsporidia are obligate, intracellular, spore-forming eukaryotic fungi that infect humans and animals. In the treatment of disseminated microsporidiosis albendazole is the choice of drug.
Cetinkaya, Ulfet, Sezer, Gulay
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Tarek A Ahmed1,2 1Department of Pharmaceutics, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia; 2Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt Background ...
Ahmed TA
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Vinpocetine regulates cation channel permeability of inner retinal neurons in the ischaemic retina
Vinpocetine is a natural drug which exerts neuroprotective effects in ischaemia of the brain through actions on cation channels, glutamate receptors and other pathways.
Acosta Etchebarne, Monica +4 more
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Vinpocetine reduced the translocation of NF-кB p65 via phosphorylation of Akt.
PD98059 and LY294002 were respectively added into the culture of β-GP-stimulated VSMCs with or without vinpocetine treatment. The results showed that phosphorylation of both ERK and Akt were blockaded by their inhibitor (A, B and D).
Qiu-Hua Liang (326253) +8 more
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The Effect of Vinpocetine on Human Cytochrome P450 Isoenzymes by Using a Cocktail Method
Vinpocetine is a derivative of the alkaloid vincamine, which had been prescribed for chronic cerebral vascular ischemia and acute ischemic stroke or used as a dietary supplement for its several different mechanisms of biological activities.
Linhu Ye +5 more
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PREPARATION TECHNOLOGY OF TABLETS WITH COMBINATIONS OF THE EXTRACT OF GINKGO AND VINPOCETIN
The paper discusses the process selection of excipients to obtain tablets containing as active ingredients Ginkgo biloba extract and vinpocetine. We used the method of experiment planning and evaluation of the results using the desirability function ...
N. V. Slovesnova +5 more
doaj
Developmental Toxicity Evaluation of the Dietary Supplement Vinpocetine Using Mouse and Human 3D Gastruloids. [PDF]
Maki A, Marikawa Y.
europepmc +1 more source
PET studies on the brain uptake and regional distribution of [11C]vinpocetine in human subjects
Objectives\u96 Vinpocetine is a compound widely used in the prevention and treatment of cerebrovascular diseases. It is still not clear whether the drug has a direct and specific effect on neurotransmission or its effects are due to extracerebral actions,
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