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High rate of potentially inappropriate medication use in older people: a case-control study. [PDF]
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Vinpocetine, cognition, and epilepsy
Epilepsy and Behavior, 2021Vinpocetine has been shown to enhance memory in animal models, with possible cognitive benefit in humans. The present study sought to demonstrate if vinpocetine can enhance cognition in healthy volunteers or patients with epilepsy. In addition, we compare blood levels of vinpocetine and its active metabolite (apovincaminic acid; AVA) in humans and ...
Kimford J Meador +2 more
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Vinpocetine (A comprehensive profile)
2022Vinpocetine (VIN) is a herbal supplement extracted from the periwinkle plant. It is a multi-action agent, which is used to treat various neurological disorders such as Alzheimer's and Parkinson's disease. Vinpocetine has also anti-inflammatory, analgesic, antioxidant property and treats various thinking and memory problems.
Nasr Y, Khalil +3 more
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Role of vinpocetine in cerebrovascular diseases
Pharmacological Reports, 2011A cerebrovascular accident, or stroke, is defined as the abrupt onset of a neurological deficit, which can be due to ischemia. Cerebral ischemia is caused by a reduction in blood flow that thereby decreases cerebral metabolism. Chronic cerebral hypoperfusion leads to irreversible brain damage and plays an important role in the development of certain ...
Sazal Patyar +2 more
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An update on vinpocetine: New discoveries and clinical implications
European Journal of Pharmacology, 2018 Vinpocetine, a derivative of the alkaloid vincamine, has been clinically used in many countries for treatment of cerebrovascular disorders such as stroke and dementia for more than 30 years. Currently, vinpocetine is also available in the market as a dietary supplement to enhance cognition and memory.
Jian-Dong Li, Chen Yan
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Synthesis and biological evaluation of Vinpocetine derivatives
Bioorganic & Medicinal Chemistry Letters, 2020A new series of Vinpocetine derivatives were synthesized and evaluated for their inhibitory activity on PDE1A in vitro. Seven compounds with higher inhibitory activity were selected for surface plasmon resonance (SPR) binding experiments. Compared with Vinpocetine, these high potency compounds presented a higher binding affinity with PDE1A, which was ...
Bo-Wen, Pan +6 more
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Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 2017
Cramps is a common symptom in amyotrophic lateral sclerosis (ALS), which can be very disturbing (1).
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Cramps is a common symptom in amyotrophic lateral sclerosis (ALS), which can be very disturbing (1).
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Effect of vinpocetine on retrograde axoplasmic transport [PDF]
Annals of Anatomy - Anatomischer Anzeiger, 2007 Vinpocetine, a derivate of vincamine, is widely used in the clinical pharmacotherapy of cerebral circulatory diseases. Herewith we report on a novel effect of vinpocetine: inhibition of retrograde axoplasmic transport of nerve growth factor (NGF) in the peripheral nerve.
Knyihár-Csillik Erzsébet +6 more
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Vinpocetine attenuates lipid accumulation and atherosclerosis formation [PDF]
Biochemical and Biophysical Research Communications, 2013 Atherosclerosis, the major cause of myocardial infarction and stroke, is a chronic arterial disease characterized by lipid deposition and inflammation in the vessel wall. Cholesterol, in low-density lipoprotein (LDL), plays a critical role in the pathogenesis of atherosclerosis. Vinpocetine, a derivative of the alkaloid vincamine, has long been used as
Yujun Cai, Jian-Dong Li, Chen Yan
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Study on the absorption of vinpocetine and apovincaminic acid
European Journal of Drug Metabolism and Pharmacokinetics, 1993The absorption of vinpocetine (Cavinton) and apovincaminic acid, compounds showing a marked difference in their physico-chemical properties, was studied in rats in in situ loop experiments by using radiolabelled compounds. In the case of apovincaminic acid, the investigations also involved the estimation of the portion of radioactivity excreted in ...
P, Pudleiner, L, Vereczkey
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