Results 161 to 170 of about 1,667 (200)
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In Vitro Antioxidant Properties of Pentoxifylline, Piracetam, and Vinpocetine
Clinical Neuropharmacology, 2002Oxygen-free radicals play an important role in several physiologic and pathophysiologic processes. In pathologic circumstances, they can modify and damage biologic systems. Because oxygen-free radicals are involved in a wide range of diseases (cerebrovascular, cardiovascular, etc.), scavenging these radicals should be considered as an important ...
Beata, Horvath +9 more
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Evaluation of the use of vinpocetine in microsporidia infections
Diagnostic Microbiology and Infectious DiseaseEncephalitozoon intestinalis is a species of microsporidia that causes serious health problems, especially in immunocompromised individuals. The drug of choice for treatment today is albendazole. However, partial effects, resistance, and serious side effects are reported.
Ülfet Çetinkaya +4 more
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Psychopharmacological effects of vinpocetine in normal healthy volunteers
European Journal of Clinical Pharmacology, 1985Twelve healthy female volunteers received pre-treatments with vinpocetine 10, 20, 40 mg and placebo (t.d.s.) for two days according to a randomised, double-blind crossover design. On the third day of treatment and 1 h following morning dosage, subjects completed a battery of psychological tests including Critical Flicker Fusion (CFF), Choice Reaction ...
Z, Subhan, I, Hindmarch
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Kinetics and Mechanisms of Vinpocetine Degradation in Aqueous Solutions
Journal of Pharmaceutical Sciences, 1988Under stressed conditions, vinpocetine (1; ethyl apovincamin-22-oate) equilibrates with vincaminic acid ethyl ester (2) and 14-epivincaminic acid ethyl ester (3), and hydrolyzes to apovincaminic acid (4). Sequentially, 2 is equilibrated with 14-epivincaminic acid ethyl ester (3) and hydrolyzes to vincaminic acid (5), which equilibrates with 4 and 14 ...
N, Muhammad, G, Adams, H K, Lee
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[Vinpocetin in neurological diseases].
Ideggyogyaszati szemle, 2013Stroke is the third leading cause of death worldwide (following cardiovascular and cancer mortality) and associated with serious disability for the vast majority of patients. There is no salvage therapy for irreversibly damaged brain areas, improving the circulation of the surrounding hypoperfused areas may be associated with beneficial clinical ...
László, Szapáry +9 more
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Pharmacokinetics of vinpocetine in humans.
Arzneimittel-Forschung, 1979The pharmacokinetics of ethyl-apovincaminate (vinpocetine, Cavinton), a new vincamine derivative has been studied in volunteers after p.o. and i.v. administration. The concentration of the drug was determined by mass-fragmentography in human plasma. There was a biphasic elimination of the substance after i.v.
L, Vereczkey +5 more
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[Pharmacokinetics and disposition of vinpocetine in rats].
Yao xue xue bao = Acta pharmaceutica Sinica, 1994A reverse-phase HPLC method for determination of vinpocetine in biological samples was developed. The method was simple, highly specific and accurate. After i.v. administration of vinpocetine in rats, the plasma concentration-time curves of vinpocetine was found to be fitted to a two-compartment open model.
J H, Yao, C Y, Su, X Y, Chu
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Pharmacokinetics of vinpocetine (Cavinton) in dog.
Polish journal of pharmacology and pharmacy, 1985The pharmacokinetics of vinpocetine after 10 mg po and iv doses was studied in six beagle dogs treated in cross-over design. The concentration of the drug in plasma was determined by gas-liquid chromatography using N-P FID and capillary column. The elimination half-live and clearance values calculated from time plasma concentration data for iv ...
M, Polgár, L, Vereczkey
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Kinetic metabolism of vinpocetine in the rat.
Arzneimittel-Forschung, 1979The pharmacokinetics of vinpocetine (Cavinton), a new potent vasodilator, and of its main metabolite have been studied in rats by specific extraction and radio thin-layer chromatography following i.v. and p.o. administration. The drug is rapidly eliminated, its half-life was found to be 125 min.
L, Vereczkey, Z, Szentirmay, L, Szporny
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Vinpocetine pharmacokinetics in elderly subjects.
Arzneimittel-Forschung, 1990The pharmacokinetics of vinpocetine (Eusenium) were investigated in 20 elderly, healthy volunteers. Plasma levels of the drug were determined during one dose interval of either repeated intravenous infusion or oral administration. AUC, Cmax and tmax values were derived for oral application, AUC values in case of intravenous application.
R, Grandt +3 more
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