Results 91 to 100 of about 2,254,091 (312)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Ecological pathways to prevention: How does the SASA! community mobilisation model work to prevent physical intimate partner violence against women?

BMC Public Health, 2016
Background Intimate partner violence (IPV) against women is a global public health concern. While community-level gender norms and attitudes to IPV are recognised drivers of IPV risk, there is little evidence on how interventions might tackle these ...
Tanya Abramsky, Karen M. Devries, Lori Michau, Janet Nakuti, Tina Musuya, Ligia Kiss, Nambusi Kyegombe, Charlotte Watts   +7 more
doaj   +1 more source

Royal Commission into Family Violence: issues paper [PDF]

The purpose of this issues paper is to provide general guidance to individuals and organisations in making written submissions to the Royal Commission into Family Violence. Introduction The Royal Commission into Family Violence (‘the Royal Commission’)
Royal Commission into Family Violence
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COPING MAHASISWA YANG MENGALAMI KEKERASAN DALAM PACARAN [PDF]

, 2007
During intimate relationship, there is not only beauty and happiness, but also problems and fight, even the violence. The behavior which can be groupped as the violence in dating if one of them is offended or hurt by their pair.
Narulita, Sari
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Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Global and Regional Estimates of Violence Against Women: Prevalence and Health Effects of Intimate Partner Violence and Non-Partner Sexual Violence [PDF]

, 2013
Violence against women is a significant public health problem, as well as a fundamental violation of women's human rights.This report, developed by the World Health Organization, the London School of Hygiene and Tropical Medicine and the South African ...
Christina Pallitto, Claudia Garcia-Moreno, Heidi Stöckl, Karen Devries, Naeemah Abrahams   +4 more
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Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Law, Social Movements, and the Political Economy of Domestic Violence [PDF]

, 2013
This article uses the occasion of the 2013 Reauthorization of the Violence Against Women Act (VAWA) to review the circumstances by which legal theory and social movement discourse have circumscribed the scope of VAWA and the dominant approach to domestic
Weissman, Deborah M.
core   +2 more sources

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Stepping together for children after trauma: protocol for a randomized controlled trial of a parent-led treatment in first-line services (NorStep Study)

European Journal of Psychotraumatology
Background: Childhood trauma is a public health challenge, and there is currently a service/needs gap. Low-intensive treatments where the task of leading the treatment is partially shifted to a caregiver can help bridge this gap by freeing therapist ...
Silje Mørup Ormhaug, Tine K. Jensen, Kate Louise Porcheret, Anne Lie Andreassen, Sarah Byford, Else Merete Kvalsvik Fagermoen, Pernille Gurandsrud, Kristin Johanne Økern Haabrekke, Marie Lindebø Knutsen, Heidi Maria Päivärinne, Ingeborg Skjærvø   +10 more
doaj   +1 more source