Results 151 to 160 of about 2,254,091 (312)

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Past political violence and interpersonal violence against children and youth in Africa. [PDF]

Nat Commun
Vigneri M, Fadare O, Devries K, Iversen V, Brück T.   +4 more
europepmc   +1 more source

The violence of criminalisation [PDF]

, 2019
Carvalho, Henrique
core  

Anchorage‐independent and faster growth in clonal population from UV‐irradiated NER‐deficient cells

FEBS Open Bio, EarlyView.
UV‐irradiated cells expressing a DDB2 mutant protein unable to interact with PCNA (DDB2PCNA‐) form clones able to grow without anchorage. Different experimental approaches reveal heterogeneity in cell cycle regulation and drug response within these clones, emphasizing the crucial role of the DDB2‐PCNA interaction in preventing cellular transformation ...
Paola Perucca, Anna Tricarico, Martina Furfaro, Priyam Ghosh, Ennio Prosperi, Lucia Anna Stivala, Ornella Cazzalini   +6 more
wiley   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Correction: Views of democracy and society and support for political violence in the USA: findings from a nationally representative survey

Injury Epidemiology
Garen J. Wintemute, Sonia L. Robinson, Andrew Crawford, Daniel Tancredi, Julia P. Schleimer, Elizabeth A. Tomsich, Paul M. Reeping, Aaron B. Shev, Veronica A. Pear   +8 more
doaj   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

Extent, Timing, and Predisposing Factors of Intimate Partner Violence in Sub-Saharan Africa: A Cross-Sectional Analysis Using Demography Health Surveys From 2015 to 2021. [PDF]

Health Sci Rep
Dadi AF, Ahmed KY, Wild K, Akalu TY, Baraki AG, Teshale AB, Alamneh TS, Tessema ZT, Kabthymer RH, Tamirat KS, Tesema GA.   +10 more
europepmc   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

The overlooked trauma: psychological violence and its impact on PTSD symptoms. [PDF]

Eur J Psychotraumatol
Gonçalves RM, Gama CMF, Junior SS, Xavier M, Volchan E, De Oliveira L, Erthal FS, Berger W, Mocaiber I, Pereira MG.   +9 more
europepmc   +1 more source