Results 151 to 160 of about 1,028,469 (308)

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

From Reactive to Proactive Care: Using AI to Detect Gender-Based Violence in Brazil. [PDF]

J Med Internet Res
Taylor L.
europepmc   +1 more source

Prévention de la violence : les faits

, 2010
iii, 127 p.Contents: Overview. -- 1.Increasing safe, stable and nurturing relationships between children and their parents and caregivers -- 2.Developing life skills in children and adolescents -- 3.Reducing availability and harmful use of alcohol -- 4 ...
World Health Organization, WHO Collaborating Centre for Violence Prevention   +1 more
core  

Yeast Gcn2 retains activity following humanization of its auto‐phosphorylation region

FEBS Open Bio, EarlyView.
Using Saccharomyces cerevisiae as a model to study Gcn2 activation and regulation is limited by the lack of antibodies detecting phosphorylated Gcn2. To overcome this, we engineered Gcn2‐HsC, a yeast Gcn2 variant recognizable by commercial anti‐human phospho‐GCN2 antibodies.
Reuben A. Anderson, Anja H. Schiemann, Evelyn Sattlegger   +2 more
wiley   +1 more source

Upon further examination : findings and recommendations from the Connecticut Domestic Violence Fatality Review Committee. 2012.

, 2011
Annual, 2011-2014; Biennial, 2015/2016; 1 online resource (5 volumes); Began with 2011; ceased with 2015/2016."This report is a product of the Connecticut Domestic Violence Fatality Review Committee, a collaboration of private, public and non-profit ...

core  

ATZ‐1 promotes DNA replication efficiency to maintain normal meiotic function

FEBS Open Bio, EarlyView.
Absence of ATZ‐1 interferes with meiotic DNA replication and cell cycle function via CHK‐1. This causes downstream defects associated with DNA damage and genomic integrity. Taken together, this study suggests that ATZ‐1 influences DNA replication efficiency and cell cycle function to maintain normal meiotic function.
Taylin E. Gourley, Luke W. Molesworth, Nethma H. Waduge, Fahimeh Eskandari, Peter R. Boag, Gregory M. Davis   +5 more
wiley   +1 more source

The association between school violence and physical child-to-parent violence: is exposure to parental violence a moderator? [PDF]

BMC Public Health
Svensson R, Andersson L, Johnson B.
europepmc   +1 more source

Upon further examination : findings and recommendations from the Connecticut Domestic Violence Fatality Review Committee. 2014.

, 2011
Annual, 2011-2014; Biennial, 2015/2016; 1 online resource (5 volumes); Began with 2011; ceased with 2015/2016."This report is a product of the Connecticut Domestic Violence Fatality Review Committee, a collaboration of private, public and non-profit ...

core  

KDAC6 alters cell morphology and motility through positive and negative modulation of F‐actin distribution

FEBS Open Bio, EarlyView.
KDAC6 has been associated with cell motility and actin structures, but specific domain contributions are not established. The two catalytic domains have differential effects on motility and F‐actin regulation, affecting cortical F‐actin density, motility, stress fibers, and cell spreading.
Taylor V. Joseph, Andrea B. Pham, Kiara E. Bornes, Razan H. Hammad, Chelsea A. Rousseve‐Ross, Thomas M. Huckaba, Terry J. Watt, Tasha B. Toro   +7 more
wiley   +1 more source

Gender-based violence against female academics in Chile: organizational vulnerability, underreporting, and work-related impact. [PDF]

Front Psychol
Briones-Labarca V, Campos ML, Araya-Piñones A, Herrera-Ortega H.   +3 more
europepmc   +1 more source